Cyclea barbata Miers
Species
KNApSAcK Entry
| Organism name | Cyclea barbata Miers |
|---|---|
| Genus | Cyclea |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cyclea barbata |
|---|---|
| Linked NCBI taxonomy ID | 152373 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001870
|
Isobebeerin
/ Isobebeerine / Isochondodendrine |
CHEMBL509310
CHEMBL1169628 |
No. 10 | No. 4 |
|
|||
|
C00025276
|
Thalrugosine
/ (+)-Thalrugosine |
C060802
|
0 / 1 | No. 10 | No. 4 |
|
||
|
C00025278
|
(+/-)-Tetrandrine
|
CHEMBL176045
CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757 |
C009438
|
26 / 23 / 48 | 6 / 16 | No. 10 | No. 4 |
|
|
C00025832
|
Cycleadrine
|
CHEMBL504256
CHEMBL509803 CHEMBL500614 |
12 / 6 / 3 | No. 10 | No. 4 |
|
||
|
C00025306
|
Fangchinoline
/ dl-Fangchinoline / 7-O-Demethyltetrandrine |
CHEMBL504256
CHEMBL509803 CHEMBL500614 |
12 / 6 / 3 | No. 10 | No. 4 |
|
||
|
C00025310
|
Homoaromoline
/ (+)-Homoaromoline / (+)-Thalrugosamine |
CHEMBL507220
CHEMBL503522 CHEMBL509855 CHEMBL1185978 |
No. 10 | No. 4 |
|
|||
|
C00025313
|
Isotetrandrine
/ Isosinomenine A / O-Methylberbamine / O,O-Dimethylobamegine / O,O'-Dimethylobamegine / O,O-Dimethylstepholine / O,O'-Dimethylstepholine |
CHEMBL176045
CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757 |
26 / 23 / 48 | No. 10 | No. 4 |
|
||
|
C00025320
|
Limacine
/ (-)-Limacine |
CHEMBL504256
CHEMBL509803 CHEMBL500614 |
12 / 6 / 3 | No. 10 | No. 4 |
|
||
|
C00025348
|
Tetrandrine N-2'-oxide
|
CHEMBL510782
|
No. 10 | No. 4 |
|
|||
|
C00025657
|
Cycleaneonine
/ (+)-Cycleanorine / (+)-Cycleaneonine |
C058226
|
No. 10 | No. 4 |
|
|||
|
C00025624
|
Repandin
/ Repandine / (-)-Repandine / N-Methyldemerarine |
CHEMBL510022
CHEMBL509999 CHEMBL1983122 |
5 / 4 / 1 | No. 10 | No. 4 |
|
||
|
C00025595
|
2-Norlimacine
/ (-)-2-Norlimacine / (-)-2-Demethyllimacine |
CHEMBL449198
|
No. 10 | No. 4 |
|
|||
|
C00025602
|
l-Curine
/ (-)-Curine / l-Bebeerine / Aristolochine / (-)-Bebeerine / Aristolochine(C36 alkaloid) |
CHEMBL1169627
|
13 / 6 / 5 | No. 10 | No. 4 |
|
||
|
C00025605
|
Faralaotrine
/ Cycleapeltin / Cycleapeltine / (-)-Cycleapeltine |
CHEMBL507220
CHEMBL503522 CHEMBL509855 CHEMBL1185978 |
No. 10 | No. 4 |
|
|||
|
C00025656
|
(+)-Cycleabarbatine
|
C085398
|
No. 10 | No. 4 |
|
|||
|
C00025571
|
Tetrandrine N-2'-oxide
/ Tetrandrine 2'beta-N-oxide / Tetrandrine mono-N-2'-oxide |
No. 10 | No. 4 |
|
||||
|
C00025295
|
beta-Cyclanoline
/ (-)-b-Cyclanoline |
CHEMBL2008127
|
No. 234 |
|
||||
|
C00025359
|
Cissamine
/ Ciclanoline / Cyclanoline / (-)-Cissamine / l-Cyclanoline / (-)-Cyclanoline / alpha-Cyclanoline |
CHEMBL2008127
|
C060801
|
No. 234 |
|
|||
|
C00025619
|
(-)-N-Methylcoclaurine
/ (R)-N-Methylcoclaurine |
CHEMBL453292
CHEMBL513109 |
No. 253 | No. 4 |
|
|||
|
C00025652
|
d-Coclaurine
/ Sanjoinine K / (R)-Coclaurine / (+)-Coclaurine / (+)-R-Coclaurine |
CHEMBL256448
CHEMBL453291 CHEMBL446211 |
8 / 17 / 10 | No. 253 | No. 4 |
|
Human Protein / Gene in interactions
44 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025278 C00025306 C00025313 C00025320 C00025602 C00025624 C00025832 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00025278 C00025306 C00025313 C00025320 C00025602 C00025624 C00025832 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00025278 C00025306 C00025313 C00025320 C00025602 C00025652 C00025832 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00025278 C00025306 C00025313 C00025320 C00025624 C00025832 | 1 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00025278 C00025306 C00025313 C00025320 C00025624 C00025832 | 2 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00025278 C00025306 C00025313 C00025320 C00025832 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00025278 C00025306 C00025313 C00025320 C00025832 | 1 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00025278 C00025306 C00025313 C00025320 C00025832 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00025306 C00025320 C00025832 | 0 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025278 C00025313 C00025602 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00025306 C00025320 C00025832 | 0 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00025306 C00025320 C00025832 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00025306 C00025320 C00025832 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025278 C00025313 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025278 C00025313 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00025278 C00025313 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00025278 C00025313 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025278 C00025313 | 1 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00025278 C00025313 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00025278 C00025313 | 4 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00025278 C00025313 | 0 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00025278 C00025313 | 7 / 37 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00025602 C00025652 | 4 / 3 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00025278 C00025313 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00025278 C00025313 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00025278 C00025313 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00025278 C00025313 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00025602 C00025652 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00025278 C00025313 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00025278 C00025313 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025278 C00025313 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00025278 C00025313 | 1 / 0 |
| P43351 | DNA repair protein RAD52 homolog | Unclassified protein | C00025602 C00025624 | 0 / 0 |
| O43603 | Galanin receptor type 2 | Galanin receptor | C00025602 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025602 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00025652 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00025602 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00025602 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00025602 | 1 / 1 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | C00025602 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00025652 | 6 / 4 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00025652 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00025652 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00025652 | 7 / 3 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00025278
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00025278
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00025278
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00025278
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00025278
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00025278
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (42)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143100 | Huntington disease; hd |
P42858
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
Diseases related to CTD interactions
16 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D013927 | Thrombosis |
C00025278
C00025276 |
| D055370 | Lung Injury |
C00025278
|
| D006331 | Heart Diseases |
C00025278
|
| D006470 | Hemorrhage |
C00025278
|
| D007239 | Infection |
C00025278
|
| D007511 | Ischemia |
C00025278
|
| D015470 | Leukemia, Myeloid, Acute |
C00025278
|
| D008106 | Liver Cirrhosis, Experimental |
C00025278
|
| D001855 | Bone Marrow Diseases |
C00025278
|
| D028361 | Mitochondrial Diseases |
C00025278
|
| D052016 | Mucositis |
C00025278
|
| D009203 | Myocardial Infarction |
C00025278
|
| D009336 | Necrosis |
C00025278
|
| D016066 | Pleural Effusion, Malignant |
C00025278
|
| D013280 | Stomatitis |
C00025278
|
| D000860 | Anoxia |
C00025278
|