Thalictrum glandulosissimum
Species
KNApSAcK Entry
| Organism name | Thalictrum glandulosissimum |
|---|---|
| Genus | Thalictrum |
| Family | Ranunculaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Thalictrum |
|---|---|
| Linked NCBI taxonomy ID | 46968 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026111
|
Berberrubine
/ 9-Berberoline |
CHEMBL203135
CHEMBL2160119 |
5 / 10 / 6 | No. 155 | No. 4 |
|
||
|
C00027785
|
8-Oxocoptisine
|
No. 439 |
|
|||||
|
C00027332
|
Cryptopin
/ Cryptopine / Kryptopine / Kryptocavin / Cryptocavine |
CHEMBL1339015
|
C007159
|
6 / 5 / 8 | No. 820 | No. 4 |
|
|
|
C00001906
|
Fumarin
/ Biflorine / Protopine / Fumarine / Corydinine |
CHEMBL453019
|
C009093
|
5 / 5 / 4 | 2 / 0 | No. 820 | No. 4 |
|
|
C00027375
|
Hernandaline
/ (+)-Hernandaline |
No. 3311 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001906 C00027332 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001906 C00027332 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001906 C00027332 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001906 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00027332 | 0 / 0 |
| Q09428 | ATP-binding cassette sub-family C member 8 | K | C00026111 | 5 / 3 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001906 | 3 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | C00026111 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00027332 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00027332 | 1 / 2 |
| Q14654 | ATP-sensitive inward rectifier potassium channel 11 | K | C00026111 | 3 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00026111 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00026111 | 2 / 1 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001906
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001906
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #606176 | Diabetes mellitus, permanent neonatal; pndm |
Q09428
Q14654 |
| #610374 | Diabetes mellitus, transient neonatal, 2 |
Q09428
|
| #610582 | Diabetes mellitus, transient neonatal, 3 |
Q14654
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #256450 | Hyperinsulinemic hypoglycemia, familial, 1; hhf1 |
Q09428
|
| #601820 | Hyperinsulinemic hypoglycemia, familial, 2; hhf2 |
Q14654
|
| #602485 | Hyperinsulinemic hypoglycemia, familial, 3; hhf3 |
Q09428
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #240800 | Hypoglycemia, leucine-induced; lih |
Q09428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00512 | Permanent neonatal diabetes mellitus (PNDM) |
Q09428
(related)
Q14654 (related) |
| H00513 | Transient neonatal diabetes mellitus (TNDM) |
Q09428
(related)
Q14654 (related) |
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
Q09428
(related)
Q14654 (related) |
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00409 | Type II diabetes mellitus |
Q14654
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|