Species

KNApSAcK Entry

Organism name Cistus ladaniferus
Genus Cistus
Family Cistaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cistus
Linked NCBI taxonomy ID 69451
Linked level genus

Family

Family in NCBI taxonomy Cistaceae
ID 69450

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005406 External link 512 Quercetin 3-xylosyl-(1->6)-glucoside
CHEMBL451224
No. 1 No. 15
C00005541 External link 512 Isorhamnetin 3-xylosyl-(1->6)-glucoside
No. 1 No. 15
C00005425 External link 512 Quercetin 3-galactoside-7-rhamnoside
CHEMBL592361
CHEMBL1774171
No. 1 No. 15
C00005737 External link 512 Myricetin 3-rutinoside
/ Myricetin-3-O-rutinoside
No. 1 No. 15
C00005169 External link 512 Nicotiflorin
/ Nicotifloroside
/ Kaempferol 3-O-rutinoside
/ Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
/ (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
CHEMBL431610
CHEMBL79790
CHEMBL255020
CHEMBL501550
CHEMBL498879
CHEMBL1419228
CHEMBL1875691
22 / 10 / 12 No. 1 No. 15
C00005409 External link 512 Quercetin 3-O-sophoroside
CHEMBL452919
C055545
No. 1 No. 15
C00005400 External link 512 Quercetin 3-rhamnosyl-(1->2)-galactoside
CHEMBL499824
C064703
No. 1 No. 15
C00005729 External link 512 Myricetin 3-glucoside
/ Myricetin 3-O-beta-D-glucoside
/ Myricetin 3-O-beta-D-glucopyranoside
CHEMBL462244
CHEMBL1221722
No. 2 No. 15
C00001260 External link 512 Nonacosane
CHEMBL428955
C047577
No. 115
C00001250 External link 512 Hentriacontane
CHEMBL257490
C049203
No. 115
C00000170 External link 512 trans-Cinnamate
/ trans-Cinnamic acid
CHEMBL27246
5 / 2 / 2 No. 904 No. 6
C00023430 External link 512 Ambreinolide
No. 1139
C00002685 External link 512 Acetophenone
CHEMBL274467
C038699
2 / 0 / 0 2 / 0 No. 2578 No. 9

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000170 C00005169 1 / 1
P15121 Aldose reductase Enzyme C00000170 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005169 1 / 1
P06746 DNA polymerase beta Enzyme C00005169 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005169 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005169 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000170 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005169 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005169 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00005169 2 / 3
Q13464 Rho-associated protein kinase 1 Rock C00002685 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000170 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005169 0 / 0
O75496 Geminin Unclassified protein C00005169 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005169 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00002685 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005169 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005169 0 / 0
P03372 Estrogen receptor NR3A1 C00000170 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005169 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005169 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005169 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005169 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005169 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005169 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005169 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005169 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005169 2 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00002685
250 ALPP, ALP, PALP, PLAP, PLAP-1 alkaline phosphatase, placental (EC:3.1.3.1) C00002685

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc Q14191
#615363 Estrogen resistance; estrr P03372
#232300 Glycogen storage disease ii P10253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (13)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)