Cucumis melo
Species
KNApSAcK Entry
| Organism name | Cucumis melo |
|---|---|
| Genus | Cucumis |
| Family | Cucurbitaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cucumis melo |
|---|---|
| Linked NCBI taxonomy ID | 3656 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cucurbitaceae |
|---|---|
| ID | 3650 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (39)
| Species | Activity |
|---|---|
| Cucumis melo L. | Anti-PMS |
| Cucumis melo L. | Antiacne |
| Cucumis melo L. | Antiaging |
| Cucumis melo L. | Antialcoholic |
| Cucumis melo L. | Antiasthmatic |
| Cucumis melo L. | Anticancer |
| Cucumis melo L. | Antiemetic |
| Cucumis melo L. | Antimastitic |
| Cucumis melo L. | Antimutagenic |
| Cucumis melo L. | Antioxidant |
| Cucumis melo L. | Antiozenic |
| Cucumis melo L. | Antiphotophobic |
| Cucumis melo L. | Antipityriasic |
| Cucumis melo L. | Antiporphyric |
| Cucumis melo L. | Antiproliferant |
| Cucumis melo L. | Antipsoriac |
| Cucumis melo L. | Antipyretic |
| Cucumis melo L. | Antistress |
| Cucumis melo L. | Antiulcer |
| Cucumis melo L. | Aphrodisiac |
| Cucumis melo L. | Cardioprotective |
| Cucumis melo L. | Demulcent |
| Cucumis melo L. | Digestive |
| Cucumis melo L. | Diuretic |
| Cucumis melo L. | Emetic |
| Cucumis melo L. | Emmenagogue |
| Cucumis melo L. | Emollient |
| Cucumis melo L. | Expectorant |
| Cucumis melo L. | Fungicide |
| Cucumis melo L. | Immunostimulant |
| Cucumis melo L. | Interferon-Synergist |
| Cucumis melo L. | Lacrimatory |
| Cucumis melo L. | Mucogenic |
| Cucumis melo L. | Phagocytotic |
| Cucumis melo L. | Stomachic |
| Cucumis melo L. | Taenifuge |
| Cucumis melo L. | Thymoprotective |
| Cucumis melo L. | Tonic |
| Cucumis melo L. | Vermifuge |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006210
|
Meloside L
/ Isoorientin 2''-O-glucopyranoside |
No. 1 | No. 15 |
|
||||
|
C00006223
|
Meloside A
/ Isovitexin 2''-O-glucoside |
No. 1 | No. 15 |
|
||||
|
C00000020
|
GA20
/ Gibberellin A20 |
No. 40 | No. 41 |
|
||||
|
C00000005
|
GA5
/ Gibberellin A5 |
No. 40 | No. 41 |
|
||||
|
C00000008
|
GA8
/ Gibberellin A8 |
No. 40 | No. 41 |
|
||||
|
C00000004
|
GA4
/ Gibberellin A4 |
No. 40 | No. 41 |
|
||||
|
C00000003
|
GA3
/ Gibberellin A3 |
CHEMBL513241
CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394 |
C007842
|
10 / 18 / 17 | No. 40 | No. 41 |
|
|
|
C00000001
|
GA1
/ Gibberellin A1 |
C422660
|
No. 40 | No. 41 |
|
|||
|
C00000034
|
GA34
/ Gibberellin A34 |
No. 40 | No. 41 |
|
||||
|
C00047647
|
19-Norlanosta-5,24-dien-11-one
|
CHEMBL563863
|
1 / 1 / 2 | No. 119 | No. 51 |
|
||
|
C00003688
|
Cucurbitacin H
|
CHEMBL551160
CHEMBL1163012 |
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00003683
|
Cucurbitacin B
|
CHEMBL367917
CHEMBL508185 CHEMBL507237 CHEMBL1708265 CHEMBL1728549 |
C041246
|
22 / 30 / 28 | No. 220 | No. 11 |
|
|
|
C00003682
|
Cucurbitacin A
|
CHEMBL455518
|
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00047845
|
Dihydroisocucurbitacin B
|
CHEMBL556138
|
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00047824
|
Cucurbitacin R
|
CHEMBL403003
CHEMBL564629 |
2 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00047823
|
Cucurbitacin G
|
CHEMBL551160
CHEMBL1163012 |
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00035843
|
Isocucurbitacin R
|
CHEMBL563715
|
1 / 1 / 2 | No. 220 | No. 11 |
|
||
|
C00029742
|
Arvenin I
|
CHEMBL540114
|
C057910
|
1 / 1 / 2 | No. 315 |
|
||
|
C00029743
|
Arvenin III
|
CHEMBL538201
|
1 / 1 / 2 | No. 315 |
|
|||
|
C00000358
|
n-Hexanol
|
CHEMBL14085
|
C036260
|
3 / 6 / 3 | No. 3722 |
|
Human Protein / Gene in interactions
30 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003682 C00003683 C00003688 C00029742 C00029743 C00035843 C00047647 C00047823 C00047824 C00047845 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000003 C00003683 | 11 / 10 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000003 C00003683 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000358 C00003683 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000003 C00003683 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000003 C00003683 | 2 / 0 |
| P20701 | Integrin alpha-L | Membrane receptor | C00003683 C00047824 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003683 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003683 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003683 | 2 / 3 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000358 | 3 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00003683 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00003683 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000358 | 3 / 2 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000003 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000003 | 0 / 1 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00003683 | 1 / 4 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003683 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003683 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003683 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000003 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003683 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003683 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000003 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000003 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003683 | 4 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003683 | 4 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00000003 | 3 / 4 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003683 | 1 / 0 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00003683 | 1 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (41)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
Q06710 (related) |
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00032 | Thyroid cancer |
Q06710
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|