PCIDB

Senecio renardi

Species

KNApSAcK Entry

Organism name Senecio renardi
Genus Senecio
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Senecio
Linked NCBI taxonomy ID 18794
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002117 External link 512 Seneciphylline
CHEMBL523911
CHEMBL1396368
CHEMBL1439490
CHEMBL1591009
C013678
14 / 12 / 13 No. 622 No. 2
C00002119 External link 512 Senkirkine
CHEMBL469650
CHEMBL470059
C009238
No. 838 No. 2

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002117 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002117 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00002117 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002117 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002117 7 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002117 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002117 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002117 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002117 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002117 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002117 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002117 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002117 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002117 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (13)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)