Species

KNApSAcK Entry

Organism name Dictamnus dasycarpus
Genus Dictamnus
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dictamnus dasycarpus
Linked NCBI taxonomy ID 714465
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (37)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029585 External link 512 Ikshusterol
/ 7alpha-Hydroxysitosterol
/ Stigmast-5-ene-3beta,7alpha-diol
/ (-)-Stigmast-5-ene-3beta,7alpha-diol
CHEMBL455367
C011486
No. 53 No. 11
C00045842 External link 512 Dictamnoside B
/ (-)-Dictamnoside B
No. 191
C00045846 External link 512 Dictamnoside I
/ (-)-Dictamnoside I
No. 191
C00045847 External link 512 Dictamnoside J
No. 191
C00045848 External link 512 Dictamnoside K
/ (-)-Dictamnoside K
No. 191
C00045845 External link 512 Dictamnoside H
/ (-)-Dictamnoside H
No. 191
C00045843 External link 512 Dictamnoside D
/ (-)-Dictamnoside D
No. 191
C00045841 External link 512 Dictamnoside A
/ (-)-Dictamnoside A
CHEMBL471091
No. 191
C00003719 External link 512 Limonin
CHEMBL1523286
CHEMBL1886762
CHEMBL1897224
CHEMBL2004366
C001546
2 / 0 / 1 1 / 1 No. 204 No. 51
C00003727 External link 512 Rutaevin
CHEMBL402437
C079993
No. 204 No. 51
C00003723 External link 512 Obacunone
CHEMBL404140
C067207
1 / 0 / 0 8 / 0 No. 204 No. 51
C00030241 External link 512 Evodol
/ Limonin diosphenol
CHEMBL521514
No. 204 No. 51
C00026468 External link 512 O-Ethylnordictamnine
No. 368 No. 7
C00002172 External link 512 Haplopine
CHEMBL455007
C012345
3 / 8 / 3 No. 368 No. 7
C00002151 External link 512 Dictamine
/ Dictamnine
CHEMBL22533
C026398
No. 368 No. 7
C00026444 External link 512 Iso-gamma-fagarine
CHEMBL447997
6 / 2 / 2 No. 624 No. 7
C00026447 External link 512 Isomaculosidine
/ 6,8-dimethoxydictamnine
No. 624 No. 7
C00026416 External link 512 Dictangustine A
No. 624 No. 7
C00026476 External link 512 Preskimmianine
CHEMBL487794
No. 781
C00039016 External link 512 Dictamdiol B
CHEMBL403868
CHEMBL404868
CHEMBL256353
No. 1461
C00030125 External link 512 Dictamdiol
CHEMBL403868
CHEMBL404868
CHEMBL256353
No. 1461
C00039015 External link 512 Dictamdiol A
CHEMBL403868
CHEMBL404868
CHEMBL256353
No. 1461
C00011939 External link 512 Fraxinellone
CHEMBL257170
CHEMBL1595442
C075391
3 / 5 / 4 No. 1461
C00036671 External link 512 9beta-Hydroxyfraxinellone
/ (-)-9beta-Hydroxyfraxinellone
CHEMBL257169
No. 1461
C00026361 External link 512 Platydesmine
/ (+)-Platydesmine
No. 1467 No. 7
C00026371 External link 512 7,8-Dimethoxyplatydesmine
/ (2S)-(-)-7,8-Dimethoxyplatydesmine
CHEMBL463650
No. 1467 No. 7
C00045850 External link 512 Dictamnoside M
/ (-)-Dictamnoside M
No. 1553
C00045844 External link 512 Dictamnoside G
No. 1553
C00049147 External link 512 Dictamnol
/ (+)-Dictamnol
No. 1952
C00038681 External link 512 Calodendrolide
CHEMBL256319
No. 1964
C00049184 External link 512 Isofraxinellone
No. 1964
C00031626 External link 512 beta-Elemol
No. 2406
C00045851 External link 512 Dictamnoside N
/ (-)-Dictamnoside N
No. 3590
C00026398 External link 512 7,8-Dimethoxymyrtopsine
/ (+)-7,8-Dimethoxymyrtopsine
CHEMBL463651
No. 4151
C00045849 External link 512 Dictamnoside L
/ (-)-Dictamnoside L
No. 4164
C00030329 External link 512 Fraxinellonone
CHEMBL403869
No. 8112
C00039017 External link 512 Dictamnusine
CHEMBL402945
No. 8190

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002172 C00026444 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00026444 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00011939 3 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00026444 0 / 0
O75496 Geminin Unclassified protein C00026444 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00026444 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002172 7 / 3
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme C00002172 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00026444 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003723 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003719 0 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00011939 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003719 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00011939 1 / 1

9 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003719
581 BAX, BCL2L4 BCL2-associated X protein C00003723
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003723
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003723
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003723
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00003723
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00003723
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00003723
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003723

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#119900 Digital clubbing, isolated congenital P15428
#232300 Glycogen storage disease ii P10253
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#174800 Mccune-albright syndrome; mas P63092
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092

KEGG DISEASE (10)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001862 Bone Resorption C00003719