| Organism name | Dictamnus dasycarpus |
|---|---|
| Genus | Dictamnus |
| Family | Rutaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Dictamnus dasycarpus |
|---|---|
| Linked NCBI taxonomy ID | 714465 |
| Linked level | species |
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00029585
|
Ikshusterol
/ 7alpha-Hydroxysitosterol / Stigmast-5-ene-3beta,7alpha-diol / (-)-Stigmast-5-ene-3beta,7alpha-diol |
CHEMBL455367
|
C011486
|
No. 53 | No. 11 |
|
||
|
C00045842
|
Dictamnoside B
/ (-)-Dictamnoside B |
No. 191 |
|
|||||
|
C00045846
|
Dictamnoside I
/ (-)-Dictamnoside I |
No. 191 |
|
|||||
|
C00045847
|
Dictamnoside J
|
No. 191 |
|
|||||
|
C00045848
|
Dictamnoside K
/ (-)-Dictamnoside K |
No. 191 |
|
|||||
|
C00045845
|
Dictamnoside H
/ (-)-Dictamnoside H |
No. 191 |
|
|||||
|
C00045843
|
Dictamnoside D
/ (-)-Dictamnoside D |
No. 191 |
|
|||||
|
C00045841
|
Dictamnoside A
/ (-)-Dictamnoside A |
CHEMBL471091
|
No. 191 |
|
||||
|
C00003719
|
Limonin
|
CHEMBL1523286
CHEMBL1886762 CHEMBL1897224 CHEMBL2004366 |
C001546
|
2 / 0 / 1 | 1 / 1 | No. 204 | No. 51 |
|
|
C00003727
|
Rutaevin
|
CHEMBL402437
|
C079993
|
No. 204 | No. 51 |
|
||
|
C00003723
|
Obacunone
|
CHEMBL404140
|
C067207
|
1 / 0 / 0 | 8 / 0 | No. 204 | No. 51 |
|
|
C00030241
|
Evodol
/ Limonin diosphenol |
CHEMBL521514
|
No. 204 | No. 51 |
|
|||
|
C00026468
|
O-Ethylnordictamnine
|
No. 368 | No. 7 |
|
||||
|
C00002172
|
Haplopine
|
CHEMBL455007
|
C012345
|
3 / 8 / 3 | No. 368 | No. 7 |
|
|
|
C00002151
|
Dictamine
/ Dictamnine |
CHEMBL22533
|
C026398
|
No. 368 | No. 7 |
|
||
|
C00026444
|
Iso-gamma-fagarine
|
CHEMBL447997
|
6 / 2 / 2 | No. 624 | No. 7 |
|
||
|
C00026447
|
Isomaculosidine
/ 6,8-dimethoxydictamnine |
No. 624 | No. 7 |
|
||||
|
C00026416
|
Dictangustine A
|
No. 624 | No. 7 |
|
||||
|
C00026476
|
Preskimmianine
|
CHEMBL487794
|
No. 781 |
|
||||
|
C00039016
|
Dictamdiol B
|
CHEMBL403868
CHEMBL404868 CHEMBL256353 |
No. 1461 |
|
||||
|
C00030125
|
Dictamdiol
|
CHEMBL403868
CHEMBL404868 CHEMBL256353 |
No. 1461 |
|
||||
|
C00039015
|
Dictamdiol A
|
CHEMBL403868
CHEMBL404868 CHEMBL256353 |
No. 1461 |
|
||||
|
C00011939
|
Fraxinellone
|
CHEMBL257170
CHEMBL1595442 |
C075391
|
3 / 5 / 4 | No. 1461 |
|
||
|
C00036671
|
9beta-Hydroxyfraxinellone
/ (-)-9beta-Hydroxyfraxinellone |
CHEMBL257169
|
No. 1461 |
|
||||
|
C00026361
|
Platydesmine
/ (+)-Platydesmine |
No. 1467 | No. 7 |
|
||||
|
C00026371
|
7,8-Dimethoxyplatydesmine
/ (2S)-(-)-7,8-Dimethoxyplatydesmine |
CHEMBL463650
|
No. 1467 | No. 7 |
|
|||
|
C00045850
|
Dictamnoside M
/ (-)-Dictamnoside M |
No. 1553 |
|
|||||
|
C00045844
|
Dictamnoside G
|
No. 1553 |
|
|||||
|
C00049147
|
Dictamnol
/ (+)-Dictamnol |
No. 1952 |
|
|||||
|
C00038681
|
Calodendrolide
|
CHEMBL256319
|
No. 1964 |
|
||||
|
C00049184
|
Isofraxinellone
|
No. 1964 |
|
|||||
|
C00031626
|
beta-Elemol
|
No. 2406 |
|
|||||
|
C00045851
|
Dictamnoside N
/ (-)-Dictamnoside N |
No. 3590 |
|
|||||
|
C00026398
|
7,8-Dimethoxymyrtopsine
/ (+)-7,8-Dimethoxymyrtopsine |
CHEMBL463651
|
No. 4151 |
|
||||
|
C00045849
|
Dictamnoside L
/ (-)-Dictamnoside L |
No. 4164 |
|
|||||
|
C00030329
|
Fraxinellonone
|
CHEMBL403869
|
No. 8112 |
|
||||
|
C00039017
|
Dictamnusine
|
CHEMBL402945
|
No. 8190 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002172 C00026444 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00026444 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00011939 | 3 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00026444 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00026444 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00026444 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002172 | 7 / 3 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00002172 | 1 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00026444 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003723 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003719 | 0 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00011939 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00003719 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00011939 | 1 / 1 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003719
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003723
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003723
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003723
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003723
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003723
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003723
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003723
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003723
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|