Cinchona pelletierana Wedd.
Species
KNApSAcK Entry
| Organism name | Cinchona pelletierana Wedd. |
|---|---|
| Genus | Cinchona |
| Family | Rubiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cinchona |
|---|---|
| Linked NCBI taxonomy ID | 43462 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Rubiaceae |
|---|---|
| ID | 24966 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002193
|
Quinine
|
CHEMBL97
CHEMBL15088 CHEMBL21578 CHEMBL1294 CHEMBL170 CHEMBL387326 CHEMBL407725 CHEMBL512340 CHEMBL522505 CHEMBL460606 CHEMBL601807 CHEMBL576997 CHEMBL1358565 CHEMBL1364159 CHEMBL1616938 CHEMBL1741006 CHEMBL1878119 CHEMBL2355467 |
D011803
|
48 / 55 / 40 | 18 / 83 | No. 1378 | No. 7 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002193 | 1 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00002193 | 1 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00002193 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00002193 | 0 / 0 |
| Q96FL8 | Multidrug and toxin extrusion protein 1 | Cation antiporter | C00002193 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002193 | 1 / 1 |
| O95342 | Bile salt export pump | drug | C00002193 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002193 | 2 / 2 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00002193 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00002193 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002193 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002193 | 3 / 1 |
| P02768 | Serum albumin | Secreted protein | C00002193 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00002193 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002193 | 0 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002193 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002193 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002193 | 0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | C00002193 | 0 / 0 |
| P46721 | Solute carrier organic anion transporter family member 1A2 | Unclassified protein | C00002193 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002193 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002193 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00002193 | 1 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002193 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002193 | 5 / 3 |
| P06276 | Cholinesterase | Hydrolase | C00002193 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002193 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002193 | 3 / 3 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00002193 | 1 / 1 |
| Q86VL8 | Multidrug and toxin extrusion protein 2 | Cation antiporter | C00002193 | 0 / 0 |
| Q14524 | Sodium channel protein type 5 subunit alpha | SCN alpha, NaV1.x | C00002193 | 9 / 7 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002193 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002193 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002193 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002193 | 0 / 0 |
| P22460 | Potassium voltage-gated channel subfamily A member 5 | KCNA, Kv1.x (Shaker) | C00002193 | 1 / 1 |
| P04156 | Major prion protein | Surface antigen | C00002193 | 6 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002193 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002193 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002193 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002193 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00002193 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002193 | 1 / 2 |
| Q9H015 | Solute carrier family 22 member 4 | Unclassified protein | C00002193 | 1 / 1 |
| O76082 | Solute carrier family 22 member 5 | Unclassified protein | C00002193 | 1 / 2 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00002193 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00002193 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00002193 | 3 / 2 |
18 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002193
|
| 351 | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 | amyloid beta (A4) precursor protein |
C00002193
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002193
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002193
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002193
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002193
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002193
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00002193
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00002193
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002193
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002193
|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00002193
|
| 338567 | KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK | potassium channel, subfamily K, member 18 |
C00002193
|
| 6580 | SLC22A1, HOCT1, OCT1, oct1_cds | solute carrier family 22 (organic cation transporter), member 1 |
C00002193
|
| 6582 | SLC22A2, OCT2 | solute carrier family 22 (organic cation transporter), member 2 |
C00002193
|
| 6581 | SLC22A3, EMT, EMTH, OCT3 | solute carrier family 22 (organic cation transporter), member 3 |
C00002193
|
| 84679 | SLC9A7, NHE-7, NHE7, SLC9A6 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 |
C00002193
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002193
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (55)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614022 | Atrial fibrillation, familial, 10; atfb10 |
Q14524
|
| #612240 | Atrial fibrillation, familial, 7; atfb7 |
P22460
|
| #108770 | Atrial standstill |
Q14524
|
| %606641 | Body mass index; bmi |
P37231
|
| #601144 | Brugada syndrome 1; brgda1 |
Q14524
|
| #601154 | Cardiomyopathy, dilated, 1e; cmd1e |
Q14524
|
| #212140 | Carnitine deficiency, systemic primary; cdsp |
O76082
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605479 | Cholestasis, benign recurrent intrahepatic, 2; bric2 |
O95342
|
| #601847 | Cholestasis, progressive familial intrahepatic, 2; pfic2 |
O95342
|
| #123400 | Creutzfeldt-jakob disease; cjd |
P04156
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #600072 | Fatal familial insomnia; ffi |
P04156
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #137440 | Gerstmann-straussler disease; gsd |
P04156
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #603218 | Huntington disease-like 1; hdl1 |
P04156
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #245300 | Kuru, susceptibility to |
P04156
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #603830 | Long qt syndrome 3; lqt3 |
Q14524
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #601665 | Obesity |
P37231
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #113900 | Progressive familial heart block, type ia; pfhb1a |
Q14524
|
| #180300 | Rheumatoid arthritis; ra |
Q9H015
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #608567 | Sick sinus syndrome 1, autosomal recessive; sss1 |
Q14524
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #606688 | Spongiform encephalopathy with neuropsychiatric features |
P04156
|
| #272120 | Sudden infant death syndrome |
Q14524
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #603829 | Ventricular fibrillation during myocardial infarction, susceptibility to |
Q14524
|
KEGG DISEASE (40)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00286 | Crohn's disease |
O76082
(related)
Q9H015 (related) |
| H00525 | Disorders of fatty-acid oxidation |
O76082
(related)
|
| H00624 | Familial cholestasis |
O95342
(related)
|
| H00061 | Prion diseases |
P04156
(related)
|
| H01243 | Huntington's disease-like syndrome |
P04156
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00731 | Atrial fibrillation |
P22460
(related)
Q14524 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
Q14524 (related) |
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
Q14524
(related)
|
| H00728 | Brugada syndrome (BRS) |
Q14524
(related)
|
| H00729 | Sick sinus syndrome (SSS) |
Q14524
(related)
|
| H00730 | Familial idiopathic ventricular fibrillation |
Q14524
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q14524
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
83 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D015746 | Abdominal Pain |
C00002193
|
| D000014 | Abnormalities, Drug-Induced |
C00002193
|
| D058186 | Acute Kidney Injury |
C00002193
|
| D000380 | Agranulocytosis |
C00002193
|
| D000550 | Amblyopia |
C00002193
|
| D000743 | Anemia, Hemolytic |
C00002193
|
| D000855 | Anorexia |
C00002193
|
| D001008 | Anxiety Disorders |
C00002193
|
| D001145 | Arrhythmias, Cardiac |
C00002193
|
| D054537 | Atrioventricular Block |
C00002193
|
| D001766 | Blindness |
C00002193
|
| D001919 | Bradycardia |
C00002193
|
| D001943 | Breast Neoplasms |
C00002193
|
| D002637 | Chest Pain |
C00002193
|
| D016770 | Ciliophora Infections |
C00002193
|
| D003128 | COMA |
C00002193
|
| D003221 | Confusion |
C00002193
|
| D003638 | Deafness |
C00002193
|
| D003872 | Dermatitis |
C00002193
|
| D004195 | Disease Models, Animal |
C00002193
|
| D004211 | Disseminated Intravascular Coagulation |
C00002193
|
| D004244 | Dizziness |
C00002193
|
| D003875 | Drug Eruptions |
C00002193
|
| D056486 | Drug-Induced Liver Injury |
C00002193
|
| D062787 | Drug Overdose |
C00002193
|
| D004417 | Dyspnea |
C00002193
|
| D004421 | Dystonia |
C00002193
|
| D004830 | Epilepsy, Tonic-Clonic |
C00002193
|
| D005315 | Fetal Diseases |
C00002193
|
| D005334 | Fever |
C00002193
|
| D005393 | Fish Diseases |
C00002193
|
| D006099 | Granuloma |
C00002193
|
| D006261 | Headache |
C00002193
|
| D006311 | Hearing Disorders |
C00002193
|
| D034381 | Hearing Loss |
C00002193
|
| D006319 | Hearing Loss, Sensorineural |
C00002193
|
| D006331 | Heart Diseases |
C00002193
|
| D006461 | Hemolysis |
C00002193
|
| D006463 | Hemolytic-Uremic Syndrome |
C00002193
|
| D006470 | Hemorrhage |
C00002193
|
| D006505 | Hepatitis |
C00002193
|
| D006948 | Hyperkinesis |
C00002193
|
| D007008 | Hypokalemia |
C00002193
|
| D007022 | Hypotension |
C00002193
|
| D007024 | Hypotension, Orthostatic |
C00002193
|
| D007673 | Kidney Cortex Necrosis |
C00002193
|
| D008133 | Long QT Syndrome |
C00002193
|
| D008269 | Macular Edema |
C00002193
|
| D008288 | Malaria |
C00002193
|
| D016779 | Malaria, Cerebral |
C00002193
|
| D016778 | Malaria, Falciparum |
C00002193
|
| D009120 | Muscle Cramp |
C00002193
|
| D009224 | Myotonia Congenita |
C00002193
|
| D009336 | Necrosis |
C00002193
|
| D009395 | Nephritis, Interstitial |
C00002193
|
| D009468 | Neuromuscular Diseases |
C00002193
|
| D009503 | Neutropenia |
C00002193
|
| D009896 | Optic Atrophy |
C00002193
|
| D009901 | Optic Nerve Diseases |
C00002193
|
| D010146 | Pain |
C00002193
|
| D010198 | Pancytopenia |
C00002193
|
| D018512 | Parasitemia |
C00002193
|
| D010787 | Photosensitivity Disorders |
C00002193
|
| D011041 | Poisoning |
C00002193
|
| D011618 | Psychotic Disorders |
C00002193
|
| D011697 | Purpura, Thrombotic Thrombocytopenic |
C00002193
|
| D051437 | Renal Insufficiency |
C00002193
|
| D012164 | Retinal Diseases |
C00002193
|
| D012206 | Rhabdomyolysis |
C00002193
|
| D012640 | Seizures |
C00002193
|
| D020922 | Sleep-Wake Transition Disorders |
C00002193
|
| D013575 | Syncope |
C00002193
|
| D013610 | Tachycardia |
C00002193
|
| D013921 | Thrombocytopenia |
C00002193
|
| D057049 | Thrombotic Microangiopathies |
C00002193
|
| D014012 | Tinnitus |
C00002193
|
| D015845 | Tonic Pupil |
C00002193
|
| D016171 | Torsades de Pointes |
C00002193
|
| D014657 | Vasculitis |
C00002193
|
| D014693 | Ventricular Fibrillation |
C00002193
|
| D018879 | Ventricular Premature Complexes |
C00002193
|
| D014786 | Vision Disorders |
C00002193
|
| D014839 | Vomiting |
C00002193
|