Couroupita guianensis

• Index
• Plant Species
• Natural Activity
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Couroupita guianensis
Genus	Couroupita
Family	Lecythidaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Couroupita guianensis
Linked NCBI taxonomy ID	66684
Linked level	species

Family

Family in NCBI taxonomy
ID

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Natural Activity

List (6)

Species	Activity
Couroupita guianensis Aubl.	Analgesic
Couroupita guianensis Aubl.	Antirheumatic
Couroupita guianensis Aubl.	Canicide
Couroupita guianensis Aubl.	Depilatory
Couroupita guianensis Aubl.	Poison
Couroupita guianensis Aubl.	Vulnerary

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002200	Tryptanthrin / Tryptanthrine / Couroupitine A	CHEMBL306946	C046243	20 / 22 / 23	2 / 0	No. 1798	No. 7
C00026982	Indirubin / Indigo red / Couroupitine B / Indigopurpurin	CHEMBL259664 CHEMBL1276127	C027185	16 / 11 / 8	40 / 1	No. 4840

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10636	Microtubule-associated protein tau	Unclassified protein	C00002200 C00026982	4 / 3
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002200	2 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002200	0 / 3
P02545	Prelamin-A/C	Unclassified protein	C00002200	11 / 10
P24941	Cyclin-dependent kinase 2	Cdc2	C00026982	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00026982	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002200	0 / 1
Q00535	Cyclin-dependent kinase 5	Cdk5	C00026982	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00026982	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002200	1 / 0
P11387	DNA topoisomerase 1	Isomerase	C00002200	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00002200	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00026982	2 / 3
P17538	Chymotrypsinogen B	S1A	C00026982	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00026982	1 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002200	0 / 0
P42858	Huntingtin	Unclassified protein	C00002200	1 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002200	0 / 0
O75496	Geminin	Unclassified protein	C00002200	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002200	0 / 0
P21980	Protein-glutamine gamma-glutamyltransferase 2	Enzyme	C00026982	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002200	1 / 2
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00026982	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002200	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002200	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002200	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002200	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002200	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00026982	4 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002200	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00026982	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00026982	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00026982	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00026982	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00026982	0 / 0

42 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
36	ACADSB, 2-MEBCAD, ACAD7, SBCAD	acyl-CoA dehydrogenase, short/branched chain (EC:1.3.8.5)	C00026982
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00026982
378	ARF4, ARF2	ADP-ribosylation factor 4	C00026982
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00026982
10575	CCT4, CCT-DELTA, Cctd, SRB	chaperonin containing TCP1, subunit 4 (delta)	C00026982
1000	CDH2, CD325, CDHN, CDw325, NCAD	cadherin 2, type 1, N-cadherin (neuronal)	C00026982
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00026982
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00026982
1195	CLK1, CLK, CLK/STY, STY	CDC-like kinase 1 (EC:2.7.12.1)	C00026982
9318	COPS2, ALIEN, CSN2, SGN2, TRIP15	COP9 signalosome subunit 2	C00026982
1441	CSF3R, CD114, GCSFR	colony stimulating factor 3 receptor (granulocyte)	C00026982
3577	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA	chemokine (C-X-C motif) receptor 1	C00026982
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00026982
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00026982
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00026982
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00026982
3491	CYR61, CCN1, GIG1, IGFBP10	cysteine-rich, angiogenic inducer, 61	C00026982
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00026982
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00026982
3281	HSBP1, NPC-A-13	heat shock factor binding protein 1	C00026982
3329	HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13	heat shock 60kDa protein 1 (chaperonin)	C00026982
10808	HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25	heat shock 105kDa/110kDa protein 1	C00026982
3458	IFNG, IFG, IFI	interferon, gamma	C00026982
3484	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1	insulin-like growth factor binding protein 1	C00026982
3554	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80	interleukin 1 receptor, type I	C00026982
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00026982
3608	ILF2, NF45, PRO3063	interleukin enhancer binding factor 2	C00026982
3688	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	C00026982
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00026982
4258	MGST2, GST2, MGST-II	microsomal glutathione S-transferase 2 (EC:2.5.1.18)	C00026982
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00026982
653361	NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox	neutrophil cytosolic factor 1	C00026982
4864	NPC1, NPC	Niemann-Pick disease, type C1	C00026982
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00026982
4735	SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5	septin 2	C00026982
6514	SLC2A2, GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	C00026982
6688	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A	spleen focus forming virus (SFFV) proviral integration oncogene	C00026982
6938	TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20	transcription factor 12	C00026982
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00026982
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00026982
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002200
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002200

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions