PCIDB

Veratrum album

Family in NCBI taxonomy	Melanthiaceae
ID	50362

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	Liliopsida
ID	4447

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster
C00029219	Verussurine / (+)-Verussurine					No. 321	No. 11
C00002257	Protoveratrine B	CHEMBL1398134 CHEMBL2165398				No. 321	No. 11
C00002256	Protoveratrine A	CHEMBL1565588 CHEMBL2105769		8 / 5 / 5		No. 321	No. 11
C00028670	Neojerminalanine / Neojerminalanine / (-)-Neojerminalanine					No. 321	No. 11
C00002253	Jervine	CHEMBL186779 CHEMBL1402135 CHEMBL1717145 CHEMBL1742371	C010206	11 / 15 / 12		No. 587	No. 11
C00029192	Veramanine					No. 587	No. 11
C00028420	Jervinone	CHEMBL1989656				No. 587	No. 11
C00027709	1-Hydroxy-5,6-dihydrojervine					No. 587	No. 11
C00002258	Protoverine		C012011			No. 607	No. 11
C00002272	Zygadenine					No. 607	No. 11
C00002245	Cyclopamine	CHEMBL254129 CHEMBL1590308 CHEMBL2132004	C000541	7 / 9 / 14	0 / 8	No. 1844	No. 11

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002253 C00002256	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002253 C00002256	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002253 C00002256	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002253 C00002256	0 / 1
Q15465	Sonic hedgehog protein	Unclassified protein	C00002245 C00002253	4 / 5
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002253 C00002256	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002253	7 / 3
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002253	0 / 0
P08151	Zinc finger protein GLI1	Unclassified protein	C00002245	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00002253	1 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002256	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002256	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00002245	2 / 3
P30518	Vasopressin V2 receptor	Vasopressin and oxytocin receptor	C00002245	2 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00002256	3 / 2
Q15125	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	C00002253	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002253	0 / 0
Q99835	Smoothened homolog	Smoothened receptor (frizzled family GPCR)	C00002245	0 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002245	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002245	1 / 4

OMIM	preferred title	UniProt
#219080	Acth-independent macronodular adrenal hyperplasia; aimah	P63092
#614373	Amyotrophic lateral sclerosis 16, juvenile; als16	Q99720
#302960	Chondrodysplasia punctata 2, x-linked dominant; cdpx2	Q15125
#304800	Diabetes insipidus, nephrogenic, x-linked	P30518
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#142945	Holoprosencephaly 3; hpe3	Q15465
#603373	Hyperthyroidism, familial gestational	P16473
#609152	Hyperthyroidism, nonautoimmune	P16473
#275200	Hypothyroidism, congenital, nongoitrous, 1; chng1	P16473
#174800	Mccune-albright syndrome; mas	P63092
#611638	Microphthalmia, isolated, with coloboma 5; mcopcb5	Q15465
#607948	Mycobacterium tuberculosis, susceptibility to	P11473
#300539	Nephrogenic syndrome of inappropriate antidiuresis; nsiad	P30518
#166350	Osseous heteroplasia, progressive; poh	P63092
#102200	Pituitary adenoma, growth hormone-secreting	P63092
#601399	Platelet disorder, familial, with associated myeloid malignancy	Q01196
#174500	Polydactyly, preaxial ii; ppd2	Q15465
#103580	Pseudohypoparathyroidism, type ia; php1a	P63092
#603233	Pseudohypoparathyroidism, type ib; php1b	P63092
#612462	Pseudohypoparathyroidism, type ic; php1c	P63092
#147250	Solitary median maxillary central incisor; smmci	Q15465
#277440	Vitamin d-dependent rickets, type 2a; vddr2a	P11473

KEGG	name	UniProt
H00036	Osteosarcoma	P08684 (marker)
H00342	Tuberculosis	P11473 (related)
H00784	Localized autosomal recessive hypotrichosis	P11473 (related)
H01143	Vitamin D-dependent rickets	P11473 (related)
H01205	Coumarin resistance	P11712 (related)
H00250	Congenital nongoitrous hypothyroidism (CHNG)	P16473 (related)
H01269	Congenital hyperthyroidism	P16473 (related)
H00252	Congenital nephrogenic diabetes insipidus (NDI)	P30518 (related)
H01294	Nephrogenic syndrome of inappropriate antidiuresis (NSIAD)	P30518 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)
H00244	Pseudohypoparathyroidism	P63092 (related)
H00441	Progressive osseous heteroplasia (POH)	P63092 (related)
H00501	Fibrous dysplasia, polyostotic	P63092 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q01196 (related) Q01196 (marker)
H00003	Acute myeloid leukemia (AML)	Q01196 (related) Q01196 (marker) Q13951 (marker)
H00004	Chronic myeloid leukemia (CML)	Q01196 (related)
H00978	Thrombocytopenia (THC)	Q01196 (related)
H01194	X-linked chondrodysplasia punctata	Q15125 (related)
H00039	Basal cell carcinoma	Q15465 (related) Q99835 (related)
H00267	Holoprosencephaly (HPE)	Q15465 (related)
H00652	Solitary median maxillary central incisor syndrome	Q15465 (related)
H01027	Anophthalmia and microphthalmia (A/M)	Q15465 (related)
H01160	Schizencephaly	Q15465 (related)

MESH or OMIM	name	KNApSAcK metabolite
D000014	Abnormalities, Drug-Induced	C00002245
D002971	Cleft Lip	C00002245
D002972	Cleft Palate	C00002245
D019465	Craniofacial Abnormalities	C00002245
D004487	Edema	C00002245
D016142	Holoprosencephaly	C00002245
D007569	Jaw Abnormalities	C00002245
D049188	Prenatal Injuries	C00002245