Species

KNApSAcK Entry

Organism name Veratrum taliense
Genus Veratrum
Family Melanthiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Veratrum taliense
Linked NCBI taxonomy ID 203103
Linked level species

Family

Family in NCBI taxonomy Melanthiaceae
ID 50362

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029212 External link 512 Vertaline B
C060393
No. 265 No. 11
C00002261 External link 512 Solanidine
CHEMBL363703
CHEMBL1534747
CHEMBL1980466
C013255
5 / 5 / 8 No. 265 No. 11
C00029053 External link 512 Stenophylline B
C043148
No. 265 No. 11
C00029197 External link 512 Veramitaline
No. 265 No. 11
C00029204 External link 512 Veratroylzygadenine
No. 321 No. 11
C00029054 External link 512 Stenophylline B 3-O-beta-D-glucopyranoside
No. 520
C00029195 External link 512 Veramiline 3-O-beta-D-glucopyranoside
No. 520
C00002253 External link 512 Jervine
CHEMBL186779
CHEMBL1402135
CHEMBL1717145
CHEMBL1742371
C010206
11 / 15 / 12 No. 587 No. 11
C00027858 External link 512 Angeloylzygadenine
C077447
No. 607 No. 11
C00027692 External link 512 15-Angeloylgermine
No. 607 No. 11
C00028300 External link 512 Germine
C100083
No. 607 No. 11
C00027690 External link 512 15-(2-Methylbutyroyl)germine
No. 607 No. 11
C00027859 External link 512 Angeloylzygadenine beta-N-oxide
No. 607 No. 11
C00028870 External link 512 Pseudojervine
/ Jervine 3-O-beta-D-glucopyranoside
/ 3beta-(D-glucopyranosyloxy)-jervine
No. 3567
C00028679 External link 512 Neoverataline A
No. 4934
C00028680 External link 512 Neoverataline B
No. 4934

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q15125 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme C00002253 C00002261 1 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002253 C00002261 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002253 0 / 0
Q15465 Sonic hedgehog protein Unclassified protein C00002253 4 / 5
Q92830 Histone acetyltransferase KAT2A Enzyme C00002253 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002253 1 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002253 7 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002253 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002253 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002253 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002253 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002261 0 / 0
O00255 Menin Unclassified protein C00002261 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002261 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#302960 Chondrodysplasia punctata 2, x-linked dominant; cdpx2 Q15125
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#142945 Holoprosencephaly 3; hpe3 Q15465
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#611638 Microphthalmia, isolated, with coloboma 5; mcopcb5 Q15465
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#174500 Polydactyly, preaxial ii; ppd2 Q15465
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#147250 Solitary median maxillary central incisor; smmci Q15465

KEGG DISEASE (19)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01194 X-linked chondrodysplasia punctata Q15125 (related)
H00039 Basal cell carcinoma Q15465 (related)
H00267 Holoprosencephaly (HPE) Q15465 (related)
H00652 Solitary median maxillary central incisor syndrome Q15465 (related)
H01027 Anophthalmia and microphthalmia (A/M) Q15465 (related)
H01160 Schizencephaly Q15465 (related)