PCIDB

Calophyllum brasiliense

Species

KNApSAcK Entry

Organism name Calophyllum brasiliense
Genus Calophyllum
Family Calophyllaceae / Clusiaceae / Clusiaceae-Guttiferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Calophyllum brasiliense
Linked NCBI taxonomy ID 280748
Linked level species

Family

Family in NCBI taxonomy Calophyllaceae
ID 703253

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (27)

Species Activity
Calophyllum brasiliense Cambess. ACE-Inhibitor
Calophyllum brasiliense Cambess. Analgesic
Calophyllum brasiliense Cambess. Anticancer
Calophyllum brasiliense Cambess. AntiHIV
Calophyllum brasiliense Cambess. Antiinflammatory
Calophyllum brasiliense Cambess. Antileishmanic
Calophyllum brasiliense Cambess. Antileukemic
Calophyllum brasiliense Cambess. Antineoplastic
Calophyllum brasiliense Cambess. Antiproliferant
Calophyllum brasiliense Cambess. Antiseptic
Calophyllum brasiliense Cambess. Antispasmodic
Calophyllum brasiliense Cambess. Antitumor
Calophyllum brasiliense Cambess. Apoptotic
Calophyllum brasiliense Cambess. Astringent
Calophyllum brasiliense Cambess. Bactericide
Calophyllum brasiliense Cambess. Caspase-Inducer
Calophyllum brasiliense Cambess. Chemopreventive
Calophyllum brasiliense Cambess. Cicatrizant
Calophyllum brasiliense Cambess. Cytotoxic
Calophyllum brasiliense Cambess. Digestive
Calophyllum brasiliense Cambess. Fungicide
Calophyllum brasiliense Cambess. Gastroprotective
Calophyllum brasiliense Cambess. Gram(+)-icide
Calophyllum brasiliense Cambess. Pectoral
Calophyllum brasiliense Cambess. Sudorific
Calophyllum brasiliense Cambess. Tonic
Calophyllum brasiliense Cambess. Vulnerary

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002954 External link 512 Gentisin
/ 1,7-Dihydroxy-3-methoxyanthone
C037062
No. 3 No. 15
C00002959 External link 512 Jacareubin
CHEMBL1254294
No. 24 No. 15
C00002945 External link 512 Dehydrocycloguanandin
No. 24 No. 15
C00031484 External link 512 1,3,5,6-Tetrahydroxyxanthone
CHEMBL448040
1 / 4 / 2 No. 71 No. 15
C00044571 External link 512 Brasimarin C
/ (+)-Brasimarin C
CHEMBL476875
No. 266 No. 17
C00044570 External link 512 Brasimarin B
/ (+)-Brasimarin B
CHEMBL476706
CHEMBL516283
No. 266 No. 17
C00044611 External link 512 Calocoumarin A
CHEMBL476875
No. 266 No. 17
C00044816 External link 512 Inophyllum D
/ (+)-Inophyllum D
CHEMBL337029
CHEMBL132692
CHEMBL341394
CHEMBL422798
CHEMBL192847
CHEMBL466773
2 / 0 / 0 No. 464 No. 17
C00044815 External link 512 Inophyllum A
/ (+)-Inophyllum A
CHEMBL337029
CHEMBL132692
CHEMBL341394
CHEMBL422798
CHEMBL192847
CHEMBL466773
2 / 0 / 0 No. 464 No. 17
C00035840 External link 512 Inophyllum C
CHEMBL334946
CHEMBL336955
No. 464 No. 17
C00044569 External link 512 Brasimarin A
CHEMBL514685
No. 464 No. 17
C00010213 External link 512 Inophyllum E
/ cis-and-trans-Inophyllolide
CHEMBL334946
CHEMBL336955
No. 464 No. 17
C00002455 External link 512 Calophyllolide
C018859
No. 464 No. 17
C00019808 External link 512 Calanone
CHEMBL518283
No. 464 No. 17
C00002454 External link 512 Calanolide A
CHEMBL7187
CHEMBL7121
CHEMBL268207
CHEMBL267447
CHEMBL263086
CHEMBL269063
CHEMBL282382
CHEMBL270362
CHEMBL518356
C075959
26 / 26 / 19 No. 891 No. 25
C00019807 External link 512 Calanolide C
CHEMBL7187
CHEMBL7121
CHEMBL268207
CHEMBL267447
CHEMBL263086
CHEMBL269063
CHEMBL282382
CHEMBL270362
CHEMBL518356
26 / 26 / 19 No. 891 No. 25
C00044906 External link 512 Mammea B/BB
CHEMBL477528
CHEMBL1689184
No. 3087

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00002454 C00019807 C00044815 C00044816 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002454 C00019807 0 / 0
P04062 Glucosylceramidase Enzyme C00002454 C00019807 6 / 4
P43166 Carbonic anhydrase 7 Lyase C00002454 C00019807 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002454 C00019807 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00002454 C00019807 0 / 0
P37840 Alpha-synuclein Unclassified protein C00002454 C00019807 4 / 2
P00918 Carbonic anhydrase 2 Lyase C00002454 C00019807 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00002454 C00019807 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002454 C00019807 2 / 2
O43570 Carbonic anhydrase 12 Lyase C00002454 C00019807 1 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002454 C00019807 2 / 0
O75496 Geminin Unclassified protein C00002454 C00019807 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002454 C00019807 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002454 C00019807 1 / 1
P01215 Glycoprotein hormones alpha chain Unclassified protein C00002454 C00019807 0 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00002454 C00019807 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002454 C00019807 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002454 C00019807 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002454 C00019807 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00044815 C00044816 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002454 C00019807 1 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002454 C00019807 1 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00002454 C00019807 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002454 C00019807 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002454 C00019807 1 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002454 C00019807 7 / 3
P12821 Angiotensin-converting enzyme M2 C00031484 4 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#143860 Hyperchlorhidrosis, isolated O43570
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#267430 Renal tubular dysgenesis; rtd P12821
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P12821

KEGG DISEASE (21)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)