Species

KNApSAcK Entry

Organism name Cladrastis platycarpa
Genus Cladrastis
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cladrastis platycarpa
Linked NCBI taxonomy ID 247908
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006176 External link 512 Vicenin 1
No. 1 No. 15
C00010095 External link 512 8-O-Methylretusin 7-O-glucoside
No. 2 No. 15
C00010135 External link 512 Platycarpanetin 7-O-glucoside
No. 2 No. 15
C00010085 External link 512 Rothindin
/ Pseudobaptigenin 7-O-glucoside
No. 2 No. 15
C00009400 External link 512 8-O-Methylretusin
CHEMBL477720
No. 3 No. 15
C00006083 External link 512 Bayin
/ 8-beta-D-Glucopyranosyl-4',7-dihydroxyflavone
No. 22 No. 15
C00009406 External link 512 Fujikinetin
/ 7-Hydroxy-6-methoxy-3',4'-methylenedioxyisoflavone
CHEMBL485985
No. 27 No. 15
C00002565 External link 512 Pseudobaptigenin
CHEMBL486176
C060800
3 / 5 / 3 No. 27 No. 15
C00009478 External link 512 Platycarpanetin
No. 27 No. 15
C00009476 External link 512 Dipteryxine
/ Isoplatycarpanetin
/ 7-Hydroxy-5,6-dimethoxy-3',4'-methylenedioxyisoflavone
No. 27 No. 15
C00009415 External link 512 Cladrastin
No. 35 No. 15
C00009470 External link 512 5-Methoxyafrormosin
/ 7-Hydroxy-5,6,4'-trimethoxyisoflavone
CHEMBL457449
No. 35 No. 15
C00009471 External link 512 Iso-5-methoxyafrormosin
/ 7-Hydroxy-5,8,4'-trimethoxyisoflavone
No. 35 No. 15
C00002507 External link 512 Castanin
/ Afromosin
/ Afrormosin
/ 7-Hydroxy-6,4'-dimethoxyisoflavone
CHEMBL464404
C080240
7 / 14 / 39 1 / 0 No. 35 No. 15
C00009398 External link 512 Cladrin
/ 7-Hydroxy-3',4'-dimethoxyisoflavone
CHEMBL454746
13 / 31 / 49 No. 35 No. 15
C00010008 External link 512 2-Hydroxymaackiain
/ 2,3-Dihydroxy-8,9-methylenedioxypterocarpan
CHEMBL455617
No. 66 No. 15
C00006114 External link 512 3'-C-Glucosylisoliquiritigenin
No. 3678

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00002507 C00009398 7 / 37
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002507 C00009398 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002565 C00009398 5 / 3
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002507 C00009398 4 / 2
P51151 Ras-related protein Rab-9A Unclassified protein C00002507 C00009398 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00009398 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00009398 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00009398 7 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme C00002507 2 / 2
O75496 Geminin Unclassified protein C00002507 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00009398 3 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00009398 1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002565 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009398 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00002565 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009398 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002507 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00009398 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002507

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#609338 Carotid intimal medial thickness 1 P37231
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (51)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)