Amorpha fruticosa L.

• Index
• Plant Species
• Metabolite list (4)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Amorpha fruticosa L.
Genus	Amorpha
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Fabaceae
Linked NCBI taxonomy ID	3803
Linked level	family

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (4)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00038229	2'-Methoxyisoliquiritigenin	CHEMBL253777		7 / 20 / 19		No. 92	No. 13
C00007124	Xanthoangelol	CHEMBL494083 CHEMBL457210	C068244	20 / 30 / 25	1 / 0	No. 190	No. 13
C00002522	Deguelin / (-)-cis-Deguelin	CHEMBL393417 CHEMBL1592086	C107676	12 / 20 / 45	86 / 10	No. 589	No. 15
C00010177	Fruticin / Amorphin / Frutitsin / Amorphigenin O-vicianoside		C049147			No. 813

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002522 C00007124	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002522 C00007124	4 / 3
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00002522	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00007124	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00007124	1 / 1
P21802	Fibroblast growth factor receptor 2	TK tyrosine-protein kinase TLK subfamily	C00038229	9 / 3
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00007124	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00007124	11 / 10
P37840	Alpha-synuclein	Unclassified protein	C00007124	4 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00002522	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002522	0 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00007124	1 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00038229	1 / 8
P00352	Retinal dehydrogenase 1	Enzyme	C00007124	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00007124	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00007124	2 / 0
O75496	Geminin	Unclassified protein	C00007124	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00007124	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002522	4 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002522	0 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00038229	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00007124	1 / 1
P35968	Vascular endothelial growth factor receptor 2	Vegfr	C00038229	1 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00038229	2 / 3
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002522	0 / 0
P11362	Fibroblast growth factor receptor 1	Fgfr	C00038229	4 / 5
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002522	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002522	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00007124	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002522	1 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002522	7 / 37
P10721	Mast/stem cell growth factor receptor Kit	Pdgfr	C00038229	4 / 3
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00007124	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00007124	1 / 0
O00255	Menin	Unclassified protein	C00007124	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00007124	1 / 2
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00007124	1 / 1

86 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002522 C00007124
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00002522
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002522
51129	ANGPTL4, ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, UNQ171, pp1158	angiopoietin-like 4	C00002522
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00002522
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00002522
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002522
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002522
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00002522
672	BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53	breast cancer 1, early onset	C00002522
768	CA9, CAIX, MN	carbonic anhydrase IX (EC:4.2.1.1)	C00002522
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00002522
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002522
1001	CDH3, CDHP, HJMD, PCAD	cadherin 3, type 1, P-cadherin (placental)	C00002522
1005	CDH7, CDH7L1	cadherin 7, type 2	C00002522
1007	CDH9	cadherin 9, type 2 (T1-cadherin)	C00002522
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002522
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002522
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00002522
9075	CLDN2	claudin 2	C00002522
7122	CLDN5, AWAL, BEC1, CPETRL1, TMVCF	claudin 5	C00002522
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00002522
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002522
27123	DKK2, DKK-2	dickkopf WNT signaling pathway inhibitor 2	C00002522
27121	DKK4, DKK-4	dickkopf WNT signaling pathway inhibitor 4	C00002522
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002522
112399	EGLN3, HIFP4H3, HIFPH3, PHD3	egl-9 family hypoxia-inducible factor 3 (EC:1.14.11.29)	C00002522
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00002522
2034	EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73	endothelial PAS domain protein 1	C00002522
2487	FRZB, FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, OS1, SFRP3, SRFP3, hFIZ	frizzled-related protein	C00002522
11211	FZD10, CD350, FZ-10, Fz10, FzE7, hFz10	frizzled family receptor 10	C00002522
8322	FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4	frizzled family receptor 4	C00002522
8325	FZD8, FZ-8, hFZ8	frizzled family receptor 8	C00002522
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00002522
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002522
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002522
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00002522
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00002522
3549	IHH, BDA1, HHG2	indian hedgehog	C00002522
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00002522
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002522
3791	KDR, CD309, FLK1, VEGFR, VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase) (EC:2.7.10.1)	C00002522
4015	LOX	lysyl oxidase (EC:1.4.3.13)	C00002522
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00002522
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00002522
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00002522
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00002522
4288	MKI67, KIA, MIB-1	marker of proliferation Ki-67	C00002522
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002522
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00002522
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002522
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00002522
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002522
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00002522
4928	NUP98, ADIR2, NUP196, NUP96	nucleoporin 98kDa	C00002522
4953	ODC1, ODC	ornithine decarboxylase 1 (EC:4.1.1.17)	C00002522
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002522
5163	PDK1	pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)	C00002522
5290	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153)	C00002522
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002522
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002522
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002522
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002522
6194	RPS6, S6	ribosomal protein S6	C00002522
133	ADM, AM	adrenomedullin	C00002522
6423	SFRP2, FRP-2, SARP1, SDF-5	secreted frizzled-related protein 2	C00002522
6615	SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1	snail family zinc finger 1	C00002522
8403	SOX14, SOX28	SRY (sex determining region Y)-box 14	C00002522
11063	SOX30	SRY (sex determining region Y)-box 30	C00002522
6660	SOX5, L-SOX5	SRY (sex determining region Y)-box 5	C00002522
6714	SRC, ASV, SRC1, c-SRC, p60-Src	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)	C00002522
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00002522
6778	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C	signal transducer and activator of transcription 6, interleukin-4 induced	C00002522
412	STS, ARSC, ARSC1, ASC, ES, SSDD, XLI	steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2)	C00002522
6925	TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4, bHLHb19	transcription factor 4	C00002522
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002522
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002522
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002522
11197	WIF1, WIF-1	WNT inhibitory factor 1	C00002522
80326	WNT10A, OODD, SSPS, STHAG4	wingless-type MMTV integration site family, member 10A	C00002522
7481	WNT11, HWNT11	wingless-type MMTV integration site family, member 11	C00002522
7222233			C00002522
7472	WNT2, INT1L1, IRP	wingless-type MMTV integration site family member 2	C00002522
7482	WNT2B, WNT13, XWNT2	wingless-type MMTV integration site family, member 2B	C00002522
89780	WNT3A	wingless-type MMTV integration site family, member 3A	C00002522
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002522

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions