| Organism name | Dalbergia retusa | 
|---|---|
| Genus | Dalbergia | 
| Family | Fabaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Dalbergia retusa | 
|---|---|
| Linked NCBI taxonomy ID | 466221 | 
| Linked level | species | 
| Family in NCBI taxonomy | Fabaceae | 
|---|---|
| ID | 3803 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00009400   | 8-O-Methylretusin | CHEMBL477720 | No. 3 | No. 15 |   | |||
| C00009393   | Retusin(Dalbergia) / 7,8-Dihydroxy-4'-methoxyisoflavone | CHEMBL1290231 | No. 3 | No. 15 |   | |||
| C00004653   | Retusine / Retusin(Ariocarpus) / Quercetin 3,7,3',4'-tetramethyl ether / 5-Hydroxy-3,7,3',4'-tetramethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one | CHEMBL77966 | 3 / 3 / 0 | No. 8 | No. 15 |   | ||
| C00020660   | Obtusafuran | CHEMBL454468 | No. 179 | No. 15 |   | |||
| C00020663   | Obtustyrene | CHEMBL243670 | No. 379 |   | ||||
| C00002549   | (R)-4-Methoxydalbergione | CHEMBL255297 CHEMBL466581 CHEMBL1554531 | 18 / 23 / 57 | No. 1327 | No. 18 |   | ||
| C00020661   | Obtusaquinone | CHEMBL1333653 | 15 / 30 / 58 | No. 7566 |   | |||
| C00020662   | Obtusastyrene | No. 8631 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002549 C00020661 | 3 / 3 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002549 C00020661 | 7 / 37 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002549 C00020661 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002549 C00020661 | 4 / 3 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002549 C00020661 | 0 / 1 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00002549 C00020661 | 2 / 3 | 
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002549 C00020661 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002549 C00020661 | 0 / 0 | 
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002549 C00020661 | 0 / 0 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002549 C00020661 | 0 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002549 C00020661 | 2 / 2 | 
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00004653 | 0 / 0 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00020661 | 0 / 0 | 
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00004653 | 2 / 0 | 
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00020661 | 2 / 0 | 
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00020661 | 0 / 0 | 
| P08183 | Multidrug resistance protein 1 | drug | C00004653 | 1 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00020661 | 11 / 10 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002549 | 0 / 0 | 
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002549 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002549 | 1 / 1 | 
| O00255 | Menin | Unclassified protein | C00002549 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002549 | 1 / 2 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002549 | 0 / 1 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002549 | 1 / 4 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #614490 | Blood group, junior system; jr | Q9UNQ0 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #114500 | Colorectal cancer; crc | P18054 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #133239 | Esophageal cancer | P04637 P18054 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #612244 | Inflammatory bowel disease 13; ibd13 | P08183 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #211980 | Lung cancer | P04637 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #607948 | Mycobacterium tuberculosis, susceptibility to | P11473 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #172700 | Pick disease of brain | P10636 | 
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | Q01196 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | P04637 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 | Q9UNQ0 | 
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | P11473 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) Q01196 (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00016 | Oral cancer | P04637
                            (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P04637
                            (related) P04637 (marker) | 
| H00018 | Gastric cancer | P04637
                            (related) | 
| H00019 | Pancreatic cancer | P04637
                            (related) P04637 (marker) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) | 
| H00022 | Bladder cancer | P04637
                            (related) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) | 
| H00026 | Endometrial Cancer | P04637
                            (related) | 
| H00027 | Ovarian cancer | P04637
                            (related) | 
| H00028 | Choriocarcinoma | P04637
                            (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00031 | Breast cancer | P04637
                            (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00042 | Glioma | P04637
                            (related) P04637 (marker) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00046 | Cholangiocarcinoma | P04637
                            (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00055 | Laryngeal cancer | P04637
                            (related) P04637 (marker) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00342 | Tuberculosis | P11473
                            (related) | 
| H00784 | Localized autosomal recessive hypotrichosis | P11473
                            (related) | 
| H01143 | Vitamin D-dependent rickets | P11473
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q01196
                            (related) Q01196 (marker) Q03164 (related) Q03164 (marker) | 
| H00003 | Acute myeloid leukemia (AML) | Q01196
                            (related) Q01196 (marker) Q13951 (marker) | 
| H00978 | Thrombocytopenia (THC) | Q01196
                            (related) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q9NUW8
                            (related) |