Species

KNApSAcK Entry

Organism name Deguelia hatschbachii
Genus Deguelia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Deguelia hatschbachii
Linked NCBI taxonomy ID 132437
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002555 External link 512 Osajin
CHEMBL238188
36 / 50 / 70 No. 18 No. 15
C00009518 External link 512 Nallanin
/ Scandinone
No. 18 No. 15
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00008263 External link 512 5,4'-Dihydroxy-7-methoxy-6-C-prenylflavanone
No. 28 No. 14
C00008262 External link 512 Lupinifolin
CHEMBL559980
No. 39
C00019161 External link 512 2'-(3,3-Dimethylallyl)-2'',2''-dimethylchromene (5'',6'':4',3')-4-hydroxy-5'-methoxy stilbene
No. 186
C00009787 External link 512 Robustic acid
CHEMBL400777
C105206
11 / 26 / 54 No. 377
C00009788 External link 512 Methyl robustate
/ O-Methylrobustic acid
/ Robustic acid methyl ether
No. 377
C00019160 External link 512 4,4'-Dihydroxy-3-(3,3-dimethylallyl)-2'',2''-dimethylchromene(5'',6'':5,4)-2-methoxy-8-(propyl-2-one) deoxybenzoin
No. 893
C00019159 External link 512 6,4'-Dihydroxy-3-(3,3-dimethylallyl)-2'',2''-dimethylchromene(5'',6'':5,4)-2-methoxy deoxybenzoin
No. 893
C00019162 External link 512 3',5-Dimethoxy-4-hydroxy-4'-(3,3-dimethylallyl) stilbene
No. 1271 No. 13
C00009792 External link 512 Scandenin
CHEMBL1603825
9 / 6 / 8 No. 2734 No. 16
C00019158 External link 512 3-(4'-Hydroxyphenyl)-5-methoxy-6-(3,3-dimethylallyl)-2'',2''-dimethylchromene-(5'',6'':8,7)-3-(propyl-2-one)-4H-1-benzo-2,3-dihydropyran-2,4-dione
No. 6294

Human Protein / Gene in interactions

45 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00002555 C00009787 C00009792 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002555 C00009787 C00009792 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002555 C00009787 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009787 C00009792 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002555 C00009792 0 / 0
P04062 Glucosylceramidase Enzyme C00002555 C00009787 6 / 4
O00255 Menin Unclassified protein C00002555 C00009787 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002555 C00009787 1 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002555 C00009787 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00009787 C00009792 3 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002555 C00009792 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002555 C00009787 7 / 37
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002555 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00009792 2 / 3
P10828 Thyroid hormone receptor beta NR1A2 C00009787 3 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00002555 2 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00009792 0 / 0
P42858 Huntingtin Unclassified protein C00002555 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002555 2 / 0
O75496 Geminin Unclassified protein C00002555 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002555 4 / 2
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002555 1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00002555 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002555 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002555 11 / 10
P16050 Arachidonate 15-lipoxygenase Enzyme C00002555 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002555 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002555 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002555 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002555 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002555 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002555 0 / 0
P06746 DNA polymerase beta Enzyme C00002555 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002555 1 / 1
O00167 Eyes absent homolog 2 Enzyme C00002555 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002555 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00009792 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002555 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002555 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002555 4 / 1
P01215 Glycoprotein hormones alpha chain Unclassified protein C00002555 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002555 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (59)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (77)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749