| Organism name | Cassia spp. |
|---|---|
| Genus | Cassia |
| Family | Fabaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Cassia |
|---|---|
| Linked NCBI taxonomy ID | 53851 |
| Linked level | genus |
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00005169
|
Nicotiflorin
/ Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside |
CHEMBL431610
CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691 |
22 / 10 / 12 | No. 1 | No. 15 |
|
||
|
C00004643
|
Ombuin
/ 4',7-Dimethylquercetin / 3,5,3'-Trihydroxy-7,4'-dimethoxyflavone / 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one |
CHEMBL75589
|
1 / 1 / 1 | No. 3 | No. 15 |
|
||
|
C00008805
|
Epiafzelechin
|
CHEMBL159303
CHEMBL1326092 |
7 / 4 / 12 | No. 52 | No. 14 |
|
||
|
C00002636
|
Anisaldehyde
/ p-Anisaldehyde |
CHEMBL161598
|
C024896
|
11 / 18 / 13 | 1 / 0 | No. 1003 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00004643 C00005169 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005169 C00008805 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005169 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005169 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005169 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005169 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005169 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002636 | 3 / 1 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002636 | 1 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005169 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005169 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00005169 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00008805 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002636 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002636 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005169 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00005169 | 0 / 0 |
| Q9UM73 | ALK tyrosine kinase receptor | TKL serine/threonine protein kinase STKR type 1 subfamily | C00008805 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005169 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00008805 | 0 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002636 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002636 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002636 | 5 / 3 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002636 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002636 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002636 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00008805 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005169 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005169 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005169 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002636 | 3 / 4 |
| Q99700 | Ataxin-2 | Unclassified protein | C00005169 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00005169 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00008805 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00008805 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005169 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005169 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005169 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005169 | 2 / 1 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8989 | TRPA1, ANKTM1, FEPS | transient receptor potential cation channel, subfamily A, member 1 |
C00002636
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #613014 | Neuroblastoma, susceptibility to, 3; nblst3 |
Q9UM73
|
| #601665 | Obesity |
P37231
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00014 | Non-small cell lung cancer |
Q9UM73
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|