Species

KNApSAcK Entry

Organism name Cassia spp.
Genus Cassia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cassia
Linked NCBI taxonomy ID 53851
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005169 External link 512 Nicotiflorin
/ Nicotifloroside
/ Kaempferol 3-O-rutinoside
/ Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
/ (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
CHEMBL431610
CHEMBL79790
CHEMBL255020
CHEMBL501550
CHEMBL498879
CHEMBL1419228
CHEMBL1875691
22 / 10 / 12 No. 1 No. 15
C00004643 External link 512 Ombuin
/ 4',7-Dimethylquercetin
/ 3,5,3'-Trihydroxy-7,4'-dimethoxyflavone
/ 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL75589
1 / 1 / 1 No. 3 No. 15
C00008805 External link 512 Epiafzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00002636 External link 512 Anisaldehyde
/ p-Anisaldehyde
CHEMBL161598
C024896
11 / 18 / 13 1 / 0 No. 1003

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004643 C00005169 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005169 C00008805 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005169 0 / 0
P06746 DNA polymerase beta Enzyme C00005169 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005169 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005169 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005169 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00002636 3 / 1
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002636 1 / 1
P07237 Protein disulfide-isomerase Enzyme C00005169 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005169 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00005169 2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00008805 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002636 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002636 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005169 0 / 0
O75496 Geminin Unclassified protein C00005169 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00008805 1 / 1
Q9Y253 DNA polymerase eta Enzyme C00005169 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00008805 0 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00002636 0 / 0
P14679 Tyrosinase Oxidoreductase C00002636 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002636 5 / 3
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002636 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002636 0 / 0
P03372 Estrogen receptor NR3A1 C00002636 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00008805 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005169 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005169 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005169 0 / 0
P10275 Androgen receptor NR3C4 C00002636 3 / 4
Q99700 Ataxin-2 Unclassified protein C00005169 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005169 0 / 0
O00255 Menin Unclassified protein C00008805 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00008805 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005169 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005169 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005169 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005169 2 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00002636

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc Q14191
#615363 Estrogen resistance; estrr P03372
#613163 Gaba-transaminase deficiency P80404
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#601665 Obesity P37231
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (36)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00014 Non-small cell lung cancer Q9UM73 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)