PCIDB

Streptomyces sp. GW23/1540

Species

KNApSAcK Entry

Organism name Streptomyces sp. GW23/1540
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00043174 External link 512 2-Methyl-3H-quinazolin-4-one
CHEMBL395092
C067712
2 / 0 / 0 No. 3292
C00043612 External link 512 Isobutyramide
CHEMBL352219
C030197
No. 3721
C00043175 External link 512 2-Methylbutyramide
CHEMBL1081232
C062308
No. 3721
C00037471 External link 512 Maltol
CHEMBL31422
C008316
12 / 15 / 14 No. 4868 No. 64
C00043859 External link 512 Pyrrole-2-carboxylic acid
CHEMBL509027
7 / 4 / 4 No. 6672
C00043176 External link 512 3-(1-Carboxyvinyloxy)-benzoic acid
No. 8812

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00037471 C00043859 0 / 0
P08254 Stromelysin-1 M10A C00037471 C00043859 1 / 0
P22894 Neutrophil collagenase M10A C00037471 C00043859 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00037471 C00043859 2 / 2
P08253 72 kDa type IV collagenase M10A C00037471 C00043859 1 / 3
P03956 Interstitial collagenase M10A C00037471 C00043859 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00043174 0 / 0
P15121 Aldose reductase Enzyme C00002682 0 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00043174 0 / 0
P14920 D-amino-acid oxidase Enzyme C00043859 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
P02545 Prelamin-A/C Unclassified protein C00037471 11 / 10
P03372 Estrogen receptor NR3A1 C00002682 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002682 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00037471 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00037471 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00037471 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00037471 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00037471 0 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#610460 Thiopurine s-methyltransferase deficiency P51580

KEGG DISEASE (17)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)