Species

KNApSAcK Entry

Organism name Caesalpinia coriana
Genus Caesalpinia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Caesalpinia
Linked NCBI taxonomy ID 53845
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002911 External link 512 Chebulagic acid
CHEMBL525240
CHEMBL1970427
C076178
12 / 2 / 2 No. 226 No. 81
C00002912 External link 512 Chebulinic acid
CHEMBL501154
CHEMBL1159459
CHEMBL1391063
C103481
29 / 15 / 14 6 / 0 No. 226 No. 81

Human Protein / Gene in interactions

30 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q15139 Serine/threonine-protein kinase D1 Pkd C00002911 C00002912 0 / 0
P41743 Protein kinase C iota type Iota C00002911 C00002912 0 / 0
P24723 Protein kinase C eta type Eta C00002911 C00002912 1 / 0
P05771 Protein kinase C beta type Alpha C00002911 C00002912 0 / 0
P05129 Protein kinase C gamma type Alpha C00002911 C00002912 1 / 1
Q05655 Protein kinase C delta type Delta C00002911 C00002912 0 / 0
P17252 Protein kinase C alpha type Alpha C00002911 C00002912 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002911 C00002912 0 / 0
Q02156 Protein kinase C epsilon type Eta C00002911 C00002912 0 / 0
Q04759 Protein kinase C theta type Delta C00002911 C00002912 0 / 1
Q05513 Protein kinase C zeta type Iota C00002911 C00002912 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002912 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002912 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002912 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002912 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002912 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002912 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002912 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002912 1 / 4
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002912 1 / 2
P11387 DNA topoisomerase 1 Isomerase C00002911 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002912 1 / 0
P54132 Bloom syndrome protein Enzyme C00002912 1 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00002912 3 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002912 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002912 1 / 1
P06746 DNA polymerase beta Enzyme C00002912 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00002912 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002912 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002912 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00002912
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002912
2624 GATA2, DCML, MONOMAC, NFE1B GATA binding protein 2 C00002912
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00002912
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002912
4778 NFE2, NF-E2, p45 nuclear factor, erythroid 2 C00002912

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG name UniProt
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)