PCIDB

Tellima grandiflora

Species

KNApSAcK Entry

Organism name Tellima grandiflora
Genus Tellima
Family Saxifragaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tellima grandiflora
Linked NCBI taxonomy ID 29775
Linked level species

Family

Family in NCBI taxonomy Saxifragaceae
ID 3792

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005152 External link 512 Kaempferol 4'-glucoside
No. 2 No. 15
C00005951 External link 512 Quercetin 3-(6''-galloylgalactoside)
CHEMBL499432
No. 98
C00006040 External link 512 Myricetin 3-(6''-galloylglucoside)
No. 98
C00005958 External link 512 Quercetin 3-(6''-galloylglucoside)
CHEMBL499432
No. 98
C00006039 External link 512 Myricetin 3-(6''-galloylgalactoside)
No. 98
C00005841 External link 512 Kaempferol 3-(6''-galloylgalactoside)
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[[6-O-(3,4,5-trihydroxybenzoyl)-beta-D-galactopyranosyl]oxy]-4H-1-benzopyran-4-one
CHEMBL503183
No. 98
C00035275 External link 512 Cornusiin E
No. 126 No. 81
C00002920 External link 512 Eugeniin
CHEMBL450745
CHEMBL510512
C110634
1 / 1 / 0 No. 302 No. 81
C00002938 External link 512 Tellimagrandin I
CHEMBL450376
C087926
7 / 0 No. 302 No. 81
C00002933 External link 512 Pentagalloyl-beta-D-glucose
/ 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
/ (+)-1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
CHEMBL127911
CHEMBL262173
CHEMBL206710
CHEMBL207164
CHEMBL382408
CHEMBL377052
CHEMBL425946
CHEMBL383306
CHEMBL207014
CHEMBL1224764
CHEMBL1500249
C013185
46 / 53 / 44 5 / 0 No. 302 No. 81
C00036226 External link 512 Tellimagrandin II
CHEMBL450745
CHEMBL510512
1 / 1 / 0 No. 302 No. 81

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00742 Coagulation factor X S1A C00002920 C00002933 C00036226 1 / 0
P56817 Beta-secretase 1 A1A C00002933 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002933 4 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002933 0 / 0
P06746 DNA polymerase beta Enzyme C00002933 0 / 0
P04062 Glucosylceramidase Enzyme C00002933 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00002933 1 / 1
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00002933 4 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002933 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002933 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00002933 3 / 1
P03951 Coagulation factor XI S1A C00002933 1 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00002933 0 / 0
P54132 Bloom syndrome protein Enzyme C00002933 1 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00002933 0 / 0
P42858 Huntingtin Unclassified protein C00002933 1 / 1
O75496 Geminin Unclassified protein C00002933 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00002933 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002933 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002933 1 / 2
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00002933 5 / 4
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002933 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002933 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002933 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002933 2 / 2
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002933 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002933 4 / 3
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00002933 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002933 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002933 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002933 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002933 1 / 1
O00255 Menin Unclassified protein C00002933 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00002933 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002933 1 / 4
Q05513 Protein kinase C zeta type Iota C00002933 0 / 0
Q04759 Protein kinase C theta type Delta C00002933 0 / 1
Q02156 Protein kinase C epsilon type Eta C00002933 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002933 0 / 0
P17252 Protein kinase C alpha type Alpha C00002933 0 / 0
Q05655 Protein kinase C delta type Delta C00002933 0 / 0
P05129 Protein kinase C gamma type Alpha C00002933 1 / 1
P05771 Protein kinase C beta type Alpha C00002933 0 / 0
P24723 Protein kinase C eta type Eta C00002933 1 / 0
P41743 Protein kinase C iota type Iota C00002933 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002933 0 / 0

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002933
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002933
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002933
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002933
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002933
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00002938
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002938
2624 GATA2, DCML, MONOMAC, NFE1B GATA binding protein 2 C00002938
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00002938
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002938
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00002938
4778 NFE2, NF-E2, p45 nuclear factor, erythroid 2 C00002938

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (53)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#227600 Factor x deficiency P00742
#612416 Factor xi deficiency P03951
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#163950 Noonan syndrome 1; ns1 Q06124
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (44)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00938 Factor XI deficiency P03951 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)