Ficus microcarpa
Species
KNApSAcK Entry
| Organism name | Ficus microcarpa |
|---|---|
| Genus | Ficus |
| Family | Moraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ficus microcarpa |
|---|---|
| Linked NCBI taxonomy ID | 66385 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Moraceae |
|---|---|
| ID | 3487 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (19)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00032465
|
Ursonic acid
/ (+)-Ursonic acid |
CHEMBL51426
CHEMBL417927 CHEMBL487887 |
1 / 2 / 2 | No. 13 | No. 51 |
|
||
|
C00003558
|
Ursolic acid
|
CHEMBL297810
CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720 |
C005466
|
47 / 26 / 33 | 15 / 12 | No. 13 | No. 51 |
|
|
C00035357
|
Oleanonic acid
|
CHEMBL470029
CHEMBL574496 |
3 / 1 / 2 | No. 13 | No. 51 |
|
||
|
C00035242
|
Acetylbetulinic acid
/ (+)-Acetylbetulinic acid |
CHEMBL312687
CHEMBL182981 |
2 / 0 / 0 | No. 23 | No. 51 |
|
||
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00035186
|
(20S)-3beta-Acetoxylupan-29-oic acid
|
No. 23 | No. 51 |
|
||||
|
C00035185
|
(20S)-3beta-Acetoxy-20-hydroperoxy-30-norlupane
|
No. 23 | No. 51 |
|
||||
|
C00035253
|
Betulonic acid
/ (+)-Betulonic acid |
CHEMBL431525
CHEMBL1329485 |
8 / 15 / 11 | No. 23 | No. 51 |
|
||
|
C00032624
|
27-Nor-3beta-hydroxy-25-oxocycloartane
|
No. 129 | No. 11 |
|
||||
|
C00019007
|
Ficuisoflavone
|
CHEMBL459025
|
No. 139 |
|
||||
|
C00029633
|
Ursolic acid
/ Acetylursolic acid |
CHEMBL55086
CHEMBL410525 |
4 / 2 / 2 | No. 177 |
|
|||
|
C00035223
|
3beta-Acetoxy-1beta,11alpha-epidioxy-12-ursene
/ (+)-3beta-Acetoxy-1beta,11alpha-epidioxy-12-ursene |
No. 177 |
|
|||||
|
C00035222
|
3beta-Acetoxy-18alpha-hydroperoxy-12-oleanen-11-one
/ (+)-3beta-Acetoxy-18alpha-hydroperoxy-12-oleanen-11-one |
No. 177 |
|
|||||
|
C00040779
|
Ficuglucoside
/ 1beta-(3-Hydroxy-4,5-dimethoxyphenyl)-O-glucopyranoside |
CHEMBL2332683
|
No. 678 | No. 6 |
|
|||
|
C00019253
|
Isolupinisoflavone E
/ 5-Hydroxy-(2'',3'':7,6),(2''',3''',4',3')-bis(5-(1-hydroxy-1-methylethyl)-4,5-dihydrofurano)isoflavone |
No. 2264 |
|
|||||
|
C00035221
|
3beta-Acetoxy-12beta,13beta-epoxy-11alpha-hydroperoxyursane
|
No. 3753 |
|
|||||
|
C00002981
|
Bergenin
|
CHEMBL273019
CHEMBL1485130 CHEMBL1512567 CHEMBL1616426 CHEMBL1619590 CHEMBL1907330 CHEMBL1972686 |
C006741
|
3 / 8 / 4 | No. 4068 |
|
||
|
C00031786
|
Ficusol
/ (-)-Ficusol / Methyl (S)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxypropanoate |
No. 5229 |
|
|||||
|
C00035381
|
Racemosic acid
|
No. 5904 |
|
Human Protein / Gene in interactions
57 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003558 C00029633 C00032465 | 2 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003558 C00035253 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00003558 C00029633 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00003558 C00035357 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00003558 C00029633 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003558 C00029633 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003558 C00035357 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002981 C00003558 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003558 C00035253 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003749 C00035253 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003558 C00035253 | 11 / 10 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003558 C00003749 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003749 C00035253 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003558 | 1 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00035242 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003558 | 0 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002981 | 1 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003558 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003558 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00003558 | 1 / 1 |
| Q9UQL6 | Histone deacetylase 5 | Hydrolase | C00003558 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00003558 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00035253 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00003558 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003558 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002981 | 7 / 3 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003558 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003558 | 3 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003558 | 0 / 0 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00003558 | 0 / 0 |
| Q13547 | Histone deacetylase 1 | Hydrolase | C00003558 | 0 / 0 |
| O15379 | Histone deacetylase 3 | Hydrolase | C00003558 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003558 | 0 / 0 |
| P56524 | Histone deacetylase 4 | Hydrolase | C00003558 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003558 | 0 / 0 |
| P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00003558 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00035242 | 0 / 0 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00035357 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003558 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003558 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00035253 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003558 | 0 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003558 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003558 | 0 / 0 |
| Q9UBN7 | Histone deacetylase 6 | Hydrolase | C00003558 | 0 / 0 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00003558 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003558 | 1 / 1 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00035253 | 4 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003558 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00003558 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003558 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003558 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003558 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00003558 | 0 / 0 |
17 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00003558
|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00003558
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003558
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003558
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003558
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003558
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003558
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003558
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003558
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00003558
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003558
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003558
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00003558
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003558
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003558
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600430 | Brachydactyly-mental retardation syndrome; bdmr |
P56524
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
P35354 (related) |
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00561 | Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome |
P56524
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
16 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006528 | Carcinoma, Hepatocellular |
C00003558
C00003749 |
| D012878 | Skin Neoplasms |
C00003558
C00003749 |
| D008103 | Liver Cirrhosis |
C00003558
|
| D003921 | Diabetes Mellitus, Experimental |
C00003558
|
| D006943 | Hyperglycemia |
C00003558
|
| D006949 | Hyperlipidemias |
C00003558
|
| D006965 | Hyperplasia |
C00003558
|
| D007249 | Inflammation |
C00003558
|
| D002471 | Cell Transformation, Neoplastic |
C00003558
|
| D017202 | Myocardial Ischemia |
C00003558
|
| D009369 | Neoplasms |
C00003558
|
| D001284 | Atrophy |
C00003558
|
| D009202 | Cardiomyopathies |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|