Paeonia officinalis
Species
KNApSAcK Entry
| Organism name | Paeonia officinalis |
|---|---|
| Genus | Paeonia |
| Family | Paeoniaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Paeonia officinalis |
|---|---|
| Linked NCBI taxonomy ID | 69717 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Paeoniaceae |
|---|---|
| ID | 24943 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (25)
| Species | Activity |
|---|---|
| Paeonia officinalis L. | Abortifacient |
| Paeonia officinalis L. | Alterative |
| Paeonia officinalis L. | Analgesic |
| Paeonia officinalis L. | Antiduretic |
| Paeonia officinalis L. | Antiherpetic |
| Paeonia officinalis L. | Antiinflammatory |
| Paeonia officinalis L. | Antispasmodic |
| Paeonia officinalis L. | Antiviral |
| Paeonia officinalis L. | Astringent |
| Paeonia officinalis L. | CNS-Depressant |
| Paeonia officinalis L. | Deobstruent |
| Paeonia officinalis L. | Depurative |
| Paeonia officinalis L. | Emetic |
| Paeonia officinalis L. | Emmenagogue |
| Paeonia officinalis L. | Hemostat |
| Paeonia officinalis L. | Hypertonic |
| Paeonia officinalis L. | Hypotensive |
| Paeonia officinalis L. | Immunostimulant |
| Paeonia officinalis L. | Laxative |
| Paeonia officinalis L. | Myorelaxant |
| Paeonia officinalis L. | Poison |
| Paeonia officinalis L. | Tonic |
| Paeonia officinalis L. | Uterocontractant |
| Paeonia officinalis L. | Uterotonic |
| Paeonia officinalis L. | Vasodilator |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00022872
|
Lutein B
/ 3'-Epilutein / Calthaxanthin / (3R,3'S,6'R)-beta,epsilon-Carotene-3,3'-diol |
CHEMBL173929
CHEMBL172477 CHEMBL1559643 CHEMBL1979448 |
4 / 2 / 3 | No. 26 | No. 59 |
|
||
|
C00003011
|
Paeoniflorin
|
CHEMBL1078549
CHEMBL1397567 CHEMBL1972762 |
C015423
|
4 / 4 / 8 | 3 / 2 | No. 1566 |
|
|
|
C00010957
|
(+)-Paeonilactone C
|
No. 5099 |
|
|||||
|
C00010956
|
Paeonilactone-B
/ (+)-Paeonilactone B |
No. 6259 |
|
|||||
|
C00010955
|
Paeonilactone-A
/ (-)-Paeonilactone A |
No. 6870 |
|
Human Protein / Gene in interactions
8 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00022872 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003011 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00022872 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00022872 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003011 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00022872 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00003011 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003011 | 1 / 2 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 664 | BNIP3, NIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
C00003011
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00003011
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003011
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (6)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (11)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|