Species

KNApSAcK Entry

Organism name Cornus kousa
Genus Cornus
Family Cornaceae / Aucubaceae / Garryaceae / Helwingiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cornus kousa
Linked NCBI taxonomy ID 28501
Linked level species

Family

Family in NCBI taxonomy Cornaceae
ID 42219

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005140 External link 512 Afzelin
/ Kaempferol 3-O-alpha-rhamnoside
/ Kaempferol 3-O-alpha-L-rhamnopyranoside
CHEMBL240528
CHEMBL515798
C477954
4 / 2 / 2 No. 2 No. 15
C00005730 External link 512 Myricitrin
/ Myricetin 3-O-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnopyranoside
CHEMBL454576
CHEMBL522983
CHEMBL1599224
C008577
25 / 11 / 11 No. 2 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003102 External link 512 Cornin
/ Verbenalin
CHEMBL1080178
CHEMBL1375107
C000511
5 / 9 / 10 No. 56 No. 36
C00029633 External link 512 Ursolic acid
/ Acetylursolic acid
CHEMBL55086
CHEMBL410525
4 / 2 / 2 No. 177
C00050237 External link 512 Stenophyllin
No. 1389

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 C00005730 C00029633 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 C00005730 C00029633 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 C00005140 1 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 C00005730 1 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00003102 C00005730 4 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 C00005730 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005730 C00029633 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 C00005730 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00005730 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 C00005140 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003102 C00005138 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005138 C00005730 1 / 1
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005730 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 C00005138 4 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00005730 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005730 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003102 2 / 0
P15121 Aldose reductase Enzyme C00005138 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005730 1 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005730 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00005730 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00029633 2 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme C00005140 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00005140 1 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005730 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005730 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005730 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005730 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005730 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005730 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005730 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
O00255 Menin Unclassified protein C00003102 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003102 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005730 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005730 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005730 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#114500 Colorectal cancer; crc P84022
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (33)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138