PCIDB

Sechium edule

Species

KNApSAcK Entry

Organism name Sechium edule
Genus Sechium
Family Cucurbitaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sechium edule
Linked NCBI taxonomy ID 184140
Linked level species

Family

Family in NCBI taxonomy Cucurbitaceae
ID 3650

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (19)

Species Activity
Sechium edule (Jacq.) Sw. Allergenic
Sechium edule (Jacq.) Sw. Antiinflammatory
Sechium edule (Jacq.) Sw. Antimutagenic
Sechium edule (Jacq.) Sw. Antioxidant
Sechium edule (Jacq.) Sw. Cardioprotective
Sechium edule (Jacq.) Sw. Cicatrizant
Sechium edule (Jacq.) Sw. Diuretic
Sechium edule (Jacq.) Sw. Diuretic
Sechium edule (Jacq.) Sw. Hemostat
Sechium edule (Jacq.) Sw. Hypokalemic
Sechium edule (Jacq.) Sw. Hypotensive
Sechium edule (Jacq.) Sw. Hypotensive
Sechium edule (Jacq.) Sw. Lactagogue
Sechium edule (Jacq.) Sw. Litholytic
Sechium edule (Jacq.) Sw. Litholytic
Sechium edule (Jacq.) Sw. Ribosome-Inactivator
Sechium edule (Jacq.) Sw. Sedative
Sechium edule (Jacq.) Sw. Trypsin-Inhibitor
Sechium edule (Jacq.) Sw. Vulnerary

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000004 External link 512 GA4
/ Gibberellin A4
No. 40 No. 41
C00000007 External link 512 GA7
/ Gibberellin A7
No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000009 External link 512 GA9
/ Gibberellin A9
No. 40 No. 41
C00000044 External link 512 GA44
/ Gibberellin A44
No. 40 No. 41
C00000038 External link 512 GA38
/ Gibberellin A38
No. 40 No. 41
C00000027 External link 512 GA27
/ Gibberellin A27
No. 40 No. 41
C00000029 External link 512 GA29
/ Gibberellin A29
No. 40 No. 41
C00000015 External link 512 GA15
/ Gibberellin A15
No. 40 No. 41
C00000025 External link 512 GA25
/ Gibberellin A25
No. 187 No. 41
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00000053 External link 512 GA53
/ Gibberellin A53
No. 187 No. 41
C00000013 External link 512 GA13
/ Gibberellin A13
No. 187 No. 41
C00000012 External link 512 GA12
/ Gibberellin A12
C048462
No. 187 No. 41
C00000017 External link 512 GA17
/ Gibberellin A17
No. 187 No. 41
C00000096 External link 512 9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside
No. 989
C00000091 External link 512 trans-Zeatin
CHEMBL525239
D015026
2 / 3 / 2 0 / 1 No. 2879

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 1 / 0
P02545 Prelamin-A/C Unclassified protein C00000003 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000091 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 0 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 2 / 0
O75496 Geminin Unclassified protein C00000003 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 0 / 1
P10275 Androgen receptor NR3C4 C00000003 3 / 4
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000091 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (19)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00000091