PCIDB

Garcinia bancana MIQ

Species

KNApSAcK Entry

Organism name Garcinia bancana MIQ
Genus Garcinia
Family Clusiaceae / Clusiaceae-Guttiferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Garcinia
Linked NCBI taxonomy ID 58227
Linked level genus

Family

Family in NCBI taxonomy Clusiaceae
ID 55961

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005140 External link 512 Afzelin
/ Kaempferol 3-O-alpha-rhamnoside
/ Kaempferol 3-O-alpha-L-rhamnopyranoside
CHEMBL240528
CHEMBL515798
C477954
4 / 2 / 2 No. 2 No. 15
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00002991 External link 512 Garcinol
CHEMBL454261
CHEMBL502489
CHEMBL2087609
C054597
2 / 1 / 1 17 / 0 No. 123
C00031902 External link 512 Cambogin
/ Isogarcinol
CHEMBL458934
CHEMBL1077027
CHEMBL1098255
CHEMBL2087611
2 / 1 / 1 No. 123
C00000550 External link 512 Mellein
/ Ochracin
/ (R)-(-)-Mellein
CHEMBL226090
CHEMBL499303
2 / 2 / 0 No. 1274

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 C00023774 0 / 0
Q09472 Histone acetyltransferase p300 Enzyme C00002991 C00031902 1 / 1
Q92831 Histone acetyltransferase KAT2B Enzyme C00002991 C00031902 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00005140 1 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P06746 DNA polymerase beta Enzyme C00023774 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00000550 0 / 0
P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme C00005140 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005140 0 / 1
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00005140 1 / 1
P28340 DNA polymerase delta catalytic subunit Transferase C00000550 2 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0

20 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002991
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002991
637 BID, FP497 BH3 interacting domain death agonist C00002991
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002991
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002991
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002991
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00002991
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00002991
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002991
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002991
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002991
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002991
5295 PIK3R1, AGM7, GRB1, p85, p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) C00002991
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00002991
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002991
6714 SRC, ASV, SRC1, c-SRC, p60-Src v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) C00002991
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002991
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#612591 Colorectal cancer, susceptibility to, 10; crcs10 P28340
#608902 Drug metabolism, poor, cyp2d6-related P10635
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#615381 Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome; mdpl P28340
#613684 Rubinstein-taybi syndrome 2; rsts2 Q09472

KEGG DISEASE (3)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00504 Rubinstein-Taybi syndrome Q09472 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749