PCIDB

KNApSAcK Metabolite C00002991

Metabolite

KNApSAcK Entry

id C00002991
Name Garcinol
CAS RN 78824-30-3
Standard InChI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1
Standard InChI (Main Layer) InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3

Cluster

Phytochemical cluster
KCF-S cluster No. 123

Link

ChEMBL

By standard InChI CHEMBL502489
By standard InChI Main Layer CHEMBL454261 CHEMBL502489 CHEMBL2087609

KEGG

By LinkDB C09929

CTD

By CAS RN C054597

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q09472 Histone acetyltransferase p300 Enzyme CHEMBL502489 CHEMBL1006961 (1) CHEMBL1021613 (1)
CHEMBL1021614 (1) CHEMBL1021615 (1)
CHEMBL1021616 (1) CHEMBL1021617 (1)
CHEMBL1021618 (1)
1 / 1
Q92831 Histone acetyltransferase KAT2B Enzyme CHEMBL502489 CHEMBL1006962 (1) CHEMBL1021605 (1)
CHEMBL1021607 (1)
0 / 0

CTD interaction (20)

compound gene gene name gene description interaction interaction type form reference
pmid
C054597 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) garcinol results in decreased phosphorylation of and results in decreased activity of AKT1 protein decreases activity
/ decreases phosphorylation
protein 16052481
C054597 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 garcinol results in decreased expression of BCL2 protein decreases expression
protein 16052481
C054597 637 BID
FP497
BH3 interacting domain death agonist garcinol results in increased cleavage of BID protein increases cleavage
protein 16052481
C054597 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) garcinol results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 16052481
C054597 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) garcinol results in increased cleavage of CASP9 protein increases cleavage
protein 16052481
C054597 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic garcinol affects the localization of CYCS protein affects localization
protein 16052481
C054597 2033 EP300
KAT3B
RSTS2
p300
E1A binding protein p300 (EC:2.3.1.48) garcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
protein 19281832
C054597 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta garcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
19281832
C054597 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta garcinol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 19281832
C054597 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta garcinol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19281832
C054597 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) garcinol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 16052481
C054597 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) garcinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 16052481
C054597 4316 MMP7
MMP-7
MPSL1
PUMP-1
matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) garcinol results in decreased expression of MMP7 protein decreases expression
protein 16052481
C054597 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) garcinol results in increased cleavage of PARP1 protein increases cleavage
protein 16052481
C054597 5295 PIK3R1
AGM7
GRB1
p85
p85-ALPHA
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) garcinol results in decreased phosphorylation of and results in decreased activity of PIK3R1 protein decreases activity
/ decreases phosphorylation
protein 16052481
C054597 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) garcinol results in decreased phosphorylation of PTK2 protein decreases phosphorylation
protein 16052481
C054597 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A garcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases reaction
protein 19281832
C054597 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) garcinol results in decreased phosphorylation of and results in decreased activity of SRC protein decreases activity
/ decreases phosphorylation
protein 16052481
C054597 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 garcinol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 19281832
C054597 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 garcinol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19281832

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#613684 Rubinstein-taybi syndrome 2; rsts2 Q09472

KEGG DISEASE (1)

KEGG disease name UniProt
H00504 Rubinstein-Taybi syndrome Q09472 (related)