KEGG   Homo sapiens (human): 120892
Entry
120892            CDS       T01001                                 
Symbol
LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Name
(RefSeq) leucine rich repeat kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06463  Parkinson disease
nt06466  Pathways of neurodegeneration
  Element
N01047  Mutation-activated LRRK2 to intrinsic apoptotic pathway
Disease
H00057  Parkinson disease
H00066  Lewy body dementia (LBD)
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    120892 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    120892 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    120892 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    120892 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    120892 (LRRK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     120892 (LRRK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  LRRK family
   120892 (LRRK2)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    120892 (LRRK2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   120892 (LRRK2)
SSDB
Motif
Pfam: ARM_LRRK2 Beta-prop_LRRK2 ANK_LRRK2 Pkinase PK_Tyr_Ser-Thr LRR_8 Roc COR LRR_4 Ras LRR_14 LRR_9 WDR55 Arf LRR_13 Beta-prop_EML_2 Beta-prop_RSE1_2nd Ank_2 WD40_CDC20-Fz nSTAND3 AAA_22 T2SSE LRR_NXF1-5 Beta-prop_BBS7 ABC_tran AAA_7 G-alpha GTP_EFTU LRR_6 Kdo PduV-EutP NACHT MMR_HSR1 AAA_16 Septin TrwB_AAD_bind cobW Beta-prop_RIG_2nd WD40_Prp19 MobB ResIII AAA_29 FtsK_SpoIIIE TsaE SRPRB TniB AAA_23 WD40_WDHD1_1st Arm ARM_LIN_2nd
Other DBs
NCBI-GeneID: 120892
NCBI-ProteinID: NP_940980
OMIM: 609007
HGNC: 18618
Ensembl: ENSG00000188906
UniProt: Q5S007 Q17RV3
Structure
Position
12:40224997..40369285
AA seq 2527 aa
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
MRRTSVE
NT seq 7584 nt   +upstreamnt  +downstreamnt
atggctagtggcagctgtcaggggtgcgaagaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggaaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcgcgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcctatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaagtctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcagtgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttgctgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtctcagaggagcaactgactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtgcttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatgagtgaaagaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aattttttcaatatcctggtattaaacgaagtccatgagtttgtggtgaaagctgtgcag
cagtacccagagaatgcagcattgcagatctcagcgctcagctgtttggccctcctcact
gagactattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagataaattgttttggctggaagcctgttacaaagcattaacgtggcat
agaaagaacaagcacgtgcaggaggccgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaggaagttttccaggcatctgcgaat
gcattgtcaactctcttagaacaaaatgttaatttcagaaaaatactgttatcaaaagga
atacacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacttccctggatataatg
gcagcagtggtccccaaaatactaacagttatgaaacgtcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgcctggcatgccagaagaatcc
agggaggatacagaatttcatcataagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctattgtacattttcctgatgcattagagatgtta
tccctggaaggtgctatggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatacttgattacaaagaagaatgtgttc
ataggaactggacatctgctggcaaaaattctggtttccagcttataccgatttaaggat
gttgctgaaatacagactaaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcatttgacttagtaatattccatcaaatgtct
tccaatatcatggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgattacttaaaaaatgtgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattgggagcagatgccaatcaagcaaaggag
ggatcttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttactgaatagtggatctcgtgaacaagatgtacgaaaagcgttgacgataagcattggg
aaaggtgacagccagatcatcagcttgctcttaaggaggctggccctggatgtggccaac
aatagcatttgccttggaggattttgtataggaaaagttgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgctgtggaagaaggaacagcctcaggcagc
gatggaaatttttctgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtgtttgctcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatctaattcaattagtgtaggagaattttaccgagatgcc
gtattacagcgttgctcaccaaatttgcaaagacattccaattccttggggcccattttt
gatcatgaagatttactgaagcgaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtgttcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttatttgttgaaaatgagttgtatt
gctaatcttgatgtctctcgaaatgacattggaccctcagtggttttagatcctacagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttttgtacctgag
aacctcactgatgtggtagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaagaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttctatgacaatcctaaaatta
tctcagaacaaattttcctgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcagtacctaccaggtcccgcacactggaaatctttg
aacttaagggaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaa
gcatatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcgattaaaaaaggctgtgccttataaccgaatgaaacttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agagacaaaagaaagagagatctcgtcctaaatgtgtgggattttgcaggtcgtgaggaa
ttctatagtactcatccccattttatgacgcagcgagcattgtaccttgctgtctatgac
ctcagcaagggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcgttggcacacatttggatgtttctgatgagaag
caacgcaaagcctgcatgagtaaaatcaccaaggaactcctgaataagcgagggttccct
gccatacgagattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaacgagagccttaatttcaagatccgagatcagcttgttgttgga
cagctgattccagactgctatgtagaacttgaaaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcccgtaattgaccggaaacgattattacaactagtgagagaaaat
cagctgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtactttgtggaaccc
aagtggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggcattatttcgcgtagagatgtggaaaaatttctttcaaaaaaaaggaaa
tttccaaagaactacatgtcacagtattttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttt
ccaatgggattttggtcaagattaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatttactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcatccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gaacatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcaccattccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagttggaatttgaacaagct
ccagagtttctcctaggtgatggcagttttggatcagtttaccgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacatacatcactcaggctgttaagacaagag
cttgtggtgctttgccacctccaccaccccagtttgatatctttgctggcagctgggatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacagcacaggattgcactccacgtagctgat
ggtttgagatacctccactcagccatgattatataccgagacctgaaaccccacaatgtg
ctgcttttcacactgtatcccaatgctgccatcattgcaaagattgctgactacggcatt
gctcagtactgctgtagaatggggataaaaacatcagagggcacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattagaaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaaattaattaaacagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacgcattttattacctaaaaacgtaattgttgaatgcatggttgctacacatcac
aacagcaggaatgcaagcatttggctgggctgtgggcacaccgacagaggacagctctca
tttcttgacttaaatactgaaggatacacttctgaggaagttgctgatagtagaatattg
tgcttagccttggtgcatcttcctgttgaaaaggaaagctggattgtgtctgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattctgtcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaagttagcaatttttgaagataagactgtt
aagcttaaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccattg
atgtgtttgagtgaatccacaaattcaacggaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctaatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttttcttatgcagctttcagtgattccaacatcataacagtggtggtagac
actgctctctatattgctaagcaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgtggactaatagactgcgtgcactttttaagggaggtaatggtaaaagaa
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaaaccctctgccttcag
aagaacactgctctttggataggaactggaggaggccatattttactcctggatctttca
actcgtcgacttatacgtgtaatttacaacttttgtaattcggtcagagtcatgatgaca
gcacagctaggaagccttaaaaatgtcatgctggtattgggctacaaccggaaaaatact
gaaggtacacaaaagcagaaagagatacaatcttgcttgaccgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagacgaacatctgttgagtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (36)   
   RefGene (30)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (24)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (49)   
   RefSeq(nuc) (23)   
   GenBank (13)   
   EMBL (13)   
3D Structure (42)   
   PDB (42)   
Protein domain (50)   
   Pfam (50)   
All databases (203)   

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