KEGG   PATHWAY: dme00270Help
Entry
dme00270                    Pathway                                

Name
Cysteine and methionine metabolism - Drosophila melanogaster (fruit fly)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
dme00270  Cysteine and methionine metabolism
dme00270

Ortholog table
Module
dme_M00034  Methionine salvage pathway [PATH:dme00270]
dme_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:dme00270]
Other DBs
GO: 0006534 0006555
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG5345  Eip55E; Ecdysone-induced protein 55E, isoform B [KO:K01758] [EC:4.4.1.1]
Dmel_CG6950  Kyat; kynurenine aminotransferase, isoform B [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
Dmel_CG1753  Cbs; cystathionine beta-synthase, isoform C [KO:K01697] [EC:4.2.1.22]
Dmel_CG10621  CG10621; uncharacterized protein, isoform B [KO:K00547] [EC:2.1.1.10]
Dmel_CG10623  CG10623; uncharacterized protein, isoform B [KO:K00547] [EC:2.1.1.10]
Dmel_CG2674  Sam-S; S-adenosylmethionine synthetase, isoform C [KO:K00789] [EC:2.5.1.6]
Dmel_CG5029  SamDC; S-adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]
Dmel_CG8327  SpdS; spermidine synthase, isoform C [KO:K00797] [EC:2.5.1.16]
Dmel_CG4300  Sms; spermine synthase, isoform C [KO:K00802] [EC:2.5.1.22]
Dmel_CG4802  Mtap; methylthioadenosine phosphorylase, isoform C [KO:K00772] [EC:2.4.2.28]
Dmel_CG31115  CG31115; uncharacterized protein [KO:K00772] [EC:2.4.2.28]
Dmel_CG11334  CG11334; uncharacterized protein, isoform C [KO:K08963] [EC:5.3.1.23]
Dmel_CG11134  CG11134; uncharacterized protein, isoform B [KO:K08964] [EC:4.2.1.109]
Dmel_CG12173  CG12173; uncharacterized protein [KO:K09880] [EC:3.1.3.77]
Dmel_CG32068  Adi1; acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
Dmel_CG1461  CG1461; uncharacterized protein, isoform B [KO:K00815] [EC:2.6.1.5]
Dmel_CG11654  Ahcy; adenosylhomocysteinase, isoform C [KO:K01251] [EC:3.3.1.1]
Dmel_CG9977  AhcyL1; adenosylhomocysteinase like 1 [KO:K01251] [EC:3.3.1.1]
Dmel_CG8956  AhcyL2; adenosylhomocysteinase like 2, isoform C [KO:K01251] [EC:3.3.1.1]
Dmel_CG1673  CG1673; uncharacterized protein [KO:K00826] [EC:2.6.1.42]
Dmel_CG11241  CG11241; uncharacterized protein, isoform C [KO:K00827] [EC:2.6.1.44 2.6.1.40]
Dmel_CG2259  Gclc; Glutamate-cysteine ligase catalytic subunit, isoform C [KO:K11204] [EC:6.3.2.2]
Dmel_CG4919  Gclm; Glutamate-cysteine ligase modifier subunit, isoform B [KO:K11205]
Dmel_CG6835  Gss1; glutathione synthetase 1, isoform E [KO:K21456] [EC:6.3.2.3]
Dmel_CG5493  CG5493; uncharacterized protein, isoform B [KO:K00456] [EC:1.13.11.20]
Dmel_CG8430  Got1; glutamate oxaloacetate transaminase 1, isoform A [KO:K14454] [EC:2.6.1.1]
Dmel_CG4233  Got2; glutamate oxaloacetate transaminase 2, isoform A [KO:K14455] [EC:2.6.1.1]
Dmel_CG12279  CG12279; uncharacterized protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
Dmel_CG10160  Ldh; lactate dehydrogenase, isoform B [KO:K00016] [EC:1.1.1.27]
Dmel_CG13334  CG13334; uncharacterized protein, isoform B [KO:K00016] [EC:1.1.1.27]
Dmel_CG5362  Mdh1; malate dehydrogenase 1, isoform B [KO:K00025] [EC:1.1.1.37]
Dmel_CG10748  CG10748; uncharacterized protein [KO:K00026] [EC:1.1.1.37]
Dmel_CG10749  CG10749; uncharacterized protein [KO:K00026] [EC:1.1.1.37]
Dmel_CG7998  Mdh2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
Dmel_CG6287  CG6287; uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Dmel_CG11899  CG11899; uncharacterized protein [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
dme00010  Glycolysis / Gluconeogenesis
dme00250  Alanine, aspartate and glutamate metabolism
dme00260  Glycine, serine and threonine metabolism
dme00290  Valine, leucine and isoleucine biosynthesis
dme00430  Taurine and hypotaurine metabolism
dme00480  Glutathione metabolism
dme00620  Pyruvate metabolism
dme00640  Propanoate metabolism
dme00770  Pantothenate and CoA biosynthesis
dme00920  Sulfur metabolism
KO pathway
ko00270   

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