KEGG   PATHWAY: hsa00562Help
Entry
hsa00562                    Pathway                                

Name
Inositol phosphate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
hsa00562  Inositol phosphate metabolism
hsa00562

Ortholog table
Module
hsa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:hsa00562]
hsa_M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:hsa00562]
hsa_M00132  Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:hsa00562]
Disease
H00530  Joubert syndrome
H00692  Lowe syndrome
H00694  Dent disease
H00700  Centronuclear myopathy
H00957  Fleck corneal dystrophy (FCD)
H01195  VACTERL/VATER association
H01387  Activated PI3K-delta syndrome (APDS)
Other DBs
BSID: 82987
GO: 0006020
Organism
Homo sapiens (human) [GN:hsa]
Gene
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
4534  MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.95 3.1.3.64]
8776  MTMR1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8898  MTMR2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.95 3.1.3.64]
8897  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
9110  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
55613  MTMR8; myotubularin related protein 8 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9107  MTMR6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
9108  MTMR7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.95 3.1.3.64]
64419  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.95 3.1.3.64]
5297  PI4KA; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
5298  PI4KB; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
55361  PI4K2A; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
55300  PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
22908  SACM1L; SAC1 like phosphatidylinositide phosphatase [KO:K21797] [EC:3.1.3.-]
22876  INPP5F; inositol polyphosphate-5-phosphatase F [KO:K21798] [EC:3.1.3.-]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
138429  PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase like 1 [KO:K13712] [EC:2.7.1.68]
4952  OCRL; OCRL, inositol polyphosphate-5-phosphatase [KO:K01099] [EC:3.1.3.36]
3633  INPP5B; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
56623  INPP5E; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
8867  SYNJ1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
8871  SYNJ2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
5728  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
3635  INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
3636  INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
5288  PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5286  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
3631  INPP4A; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
8821  INPP4B; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
200576  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
79837  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
5305  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
8396  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
23236  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
5333  PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
113026  PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
84812  PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
51196  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
5335  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
89869  PLCZ1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
23007  PLCH1; phospholipase C eta 1 [KO:K19006] [EC:3.1.4.11]
9651  PLCH2; phospholipase C eta 2 [KO:K19006] [EC:3.1.4.11]
3613  IMPA2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
3612  IMPA1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
54928  IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7 3.1.3.25]
10423  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
51477  ISYNA1; inositol-3-phosphate synthase 1 [KO:K01858] [EC:5.5.1.4]
3628  INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
51763  INPP5K; inositol polyphosphate-5-phosphatase K [KO:K01106] [EC:3.1.3.56]
27124  INPP5J; inositol polyphosphate-5-phosphatase J [KO:K01106] [EC:3.1.3.56]
3632  INPP5A; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
9562  MINPP1; multiple inositol-polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.80 3.1.3.62]
3707  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
3706  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
80271  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
3705  ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.134 2.7.1.159]
253430  IPMK; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.151 2.7.1.140]
64768  IPPK; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
55586  MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]
4329  ALDH6A1; aldehyde dehydrogenase 6 family member A1 [KO:K00140] [EC:1.2.1.27 1.2.1.18]
7167  TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]
Compound
C00024  Acetyl-CoA
C00092  D-Glucose 6-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00137  myo-Inositol
C00191  D-Glucuronate
C00222  3-Oxopropanoate
C00558  D-Tagaturonate
C00641  1,2-Diacyl-sn-glycerol
C00691  2,4,6/3,5-Pentahydroxycyclohexanone
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C03659  D-Bornesitol
C03660  L-Bornesitol
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04287  3D-3,5/4-Trihydroxycyclohexane-1,2-dione
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520  1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563  D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579  Inositol 1,2,3,5,6-pentakisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06153  scyllo-Inositol
C06892  2-Deoxy-5-keto-D-gluconic acid
C06893  2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737  5-Deoxy-D-glucuronate
C19794  CDP-1L-myo-inositol
C19799  Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate
C19891  1D-chiro-Inositol
C20251  1-Keto-D-chiro-inositol
C21643  3-Dehydro-scyllo-inosose
C21644  5-Dehydro-L-gluconate
Reference
  Authors
Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y
  Title
The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.
  Journal
Microbiology 150:571-80 (2004)
DOI:10.1099/mic.0.26768-0
Reference
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.
  Title
myo-Inositol catabolism in Bacillus subtilis.
  Journal
J Biol Chem 283:10415-24 (2008)
DOI:10.1074/jbc.M708043200
KO pathway
ko00562   

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