KEGG   PATHWAY: hsa00620Help
Entry
hsa00620                    Pathway                                

Name
Pyruvate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
hsa00620  Pyruvate metabolism
hsa00620

Ortholog table
Module
hsa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00620]
Disease
H00072  Pyruvate dehydrogenase complex deficiency
H00073  Pyruvate carboxylase deficiency
H01096  Pyruvate kinase (PK) deficiency
H01354  Leigh syndrome
H01946  Glycogen storage disease type XI
H01997  Pyruvate dehydrogenase E1-alpha deficiency
H01998  Pyruvate dehydrogenase E1-beta deficiency
H01999  Pyruvate dehydrogenase E2 deficiency
H02000  Dihydrolipoamide dehydrogenase deficiency
Drug
D00123  Cyanamide (JP17)
D00131  Disulfiram (JP17/USP/INN)
Other DBs
BSID: 82998
GO: 0006090
Organism
Homo sapiens (human) [GN:hsa]
Gene
84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
5161  PDHA2; pyruvate dehydrogenase E1 alpha 2 subunit [KO:K00161] [EC:1.2.4.1]
5160  PDHA1; pyruvate dehydrogenase E1 alpha 1 subunit [KO:K00161] [EC:1.2.4.1]
5162  PDHB; pyruvate dehydrogenase E1 beta subunit [KO:K00162] [EC:1.2.4.1]
1737  DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
5315  PKM; pyruvate kinase M1/2 [KO:K00873] [EC:2.7.1.40]
5313  PKLR; pyruvate kinase L/R [KO:K12406] [EC:2.7.1.40]
31  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:2.1.3.15 6.3.4.14 6.4.1.2]
32  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:2.1.3.15 6.3.4.14 6.4.1.2]
98  ACYP2; acylphosphatase 2 [KO:K01512] [EC:3.6.1.7]
97  ACYP1; acylphosphatase 1 [KO:K01512] [EC:3.6.1.7]
217  ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]
224  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
219  ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
501  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
134526  ACOT12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
160287  LDHAL6A; lactate dehydrogenase A like 6A [KO:K00016] [EC:1.1.1.27]
92483  LDHAL6B; lactate dehydrogenase A like 6B [KO:K00016] [EC:1.1.1.27]
3939  LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945  LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948  LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
197257  LDHD; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
2739  GLO1; glyoxalase I [KO:K01759] [EC:4.4.1.5]
3029  HAGH; hydroxyacylglutathione hydrolase [KO:K01069] [EC:3.1.2.6]
9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.81 1.1.1.79]
4200  ME2; malic enzyme 2 [KO:K00027] [EC:1.1.1.38]
10873  ME3; malic enzyme 3 [KO:K00029] [EC:1.1.1.40]
4199  ME1; malic enzyme 1 [KO:K00029] [EC:1.1.1.40]
5091  PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
2271  FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
5105  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
5106  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00033  Acetate
C00036  Oxaloacetate
C00042  Succinate
C00058  Formate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00122  Fumarate
C00149  (S)-Malate
C00186  (S)-Lactate
C00227  Acetyl phosphate
C00256  (R)-Lactate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00546  Methylglyoxal
C00937  (R)-Lactaldehyde
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  (R)-2-Ethylmalate
C02504  alpha-Isopropylmalate
C03248  Acetylenedicarboxylate
C03451  (R)-S-Lactoylglutathione
C03981  2-Hydroxyethylenedicarboxylate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  Acetyl adenylate
C05994  2-Propylmalate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
KO pathway
ko00620   

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