KEGG   PATHWAY: hsa04728
Entry
hsa04728                    Pathway                                
Name
Dopaminergic synapse - Homo sapiens (human)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
hsa04728  Dopaminergic synapse
hsa04728

Network
  Element
N00410  DRD1-GNAS-AC-PKA signaling pathway
N01040  Transport of dopamine to synaptic vesicle
N01530  Dopamine metabolism
N01790  Transport of dopamine into the neuron
Drug
D00059  Levodopa (JP18/USP/INN)
D00110  Cocaine (USP)
D00136  Haloperidol (JP18/USP/INN)
D00152  Phloroglucinol (JAN)
D00197  Reserpine (JP18/USP/INN)
D00199  Ajmaline (JP18)
D00252  Carbamazepine (JP18/USP/INN)
D00270  Chlorpromazine (USP/INN)
D00283  Clozapine (JAN/USP/INN)
D00303  Disopyramide (JP18/USAN/INN)
D00308  Droperidol (JP18/USP/INN)
D00354  Lamotrigine (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00367  Mazindol (JAN/USP/INN)
D00373  Thioridazine (USP/INN)
D00374  Thiothixene (USP)
D00375  Mephenytoin (USP/INN)
D00390  Triflupromazine (USP/INN)
D00403  Methotrimeprazine (USP)
D00426  Risperidone (JP18/USP/INN)
D00454  Olanzapine (JAN/USP/INN)
D00458  Quetiapine fumarate (JP18/USP)
D00477  Procainamide hydrochloride (JP18/USP)
D00479  Prochlorperazine maleate (JP18/USP)
D00493  Prochlorperazine (JAN/USP/INN)
D00502  Pergolide mesylate (USP)
D00503  Perphenazine (JP18/USP/INN)
D00505  Phenelzine sulfate (USP)
D00512  Phenytoin (JP18/USP/INN)
D00533  Oxcarbazepine (JAN/USP/INN)
D00538  Zonisamide (JP18/USP/INN)
D00551  Tetracaine (USP/INN)
D00552  Benzocaine (USP/INN)
D00553  Prilocaine (USP/INN)
D00558  Carbidopa (USP)
D00559  Pramipexole dihydrochloride (USP)
D00560  Pimozide (JP18/USP/INN)
D00561  Sertindole (USAN/INN)
D00613  Fenoldopam mesylate (USP)
D00633  Dopamine hydrochloride (JP18/USP)
D00637  Disopyramide phosphate (JAN/USP)
D00638  Flecainide acetate (JP18/USP)
D00639  Mexiletine hydrochloride (JP18/USP)
D00640  Propafenone hydrochloride (JP18/USP)
D00642  Quinidine gluconate (USP)
D00643  Quinidine polygalacturonate
D00702  Buspirone hydrochloride (USP)
D00726  Metoclopramide (JP18/INN)
D00732  Chloroprocaine hydrochloride (USP)
D00733  Dibucaine (USP)
D00737  Etidocaine hydrochloride
D00738  Mepivacaine hydrochloride (JP18/USP)
D00739  Pramoxine hydrochloride (USP)
D00740  Procaine hydrochloride (JP18/USP)
D00741  Tetracaine hydrochloride (JP18/USP)
D00775  Riluzole (JAN/USP/INN)
D00777  Amantadine hydrochloride (JP18/USP)
D00780  Bromocriptine mesylate (USP)
D00781  Entacapone (JP18/USP/INN)
D00784  Ropinirole hydrochloride (JAN/USP)
D00785  Selegiline hydrochloride (JAN/USP)
D00786  Tolcapone (JAN/USP/INN)
D00788  Acetophenazine maleate (USAN)
D00789  Chlorpromazine hydrochloride (JP18/USP)
D00790  Chlorprothixene (JAN/USAN/INN)
D00791  Fluphenazine hydrochloride (JAN/USP)
D00792  Fluphenazine enanthate (JP18/USP)
D00793  Fluphenazine decanoate (JAN/USP)
D00794  Loxapine succinate (USP)
D00795  Mesoridazine besylate (USP)
D00796  Molindone hydrochloride (USP)
D00797  Promazine hydrochloride (USP)
D00798  Thioridazine hydrochloride (JP18/USP)
D00799  Trifluoperazine hydrochloride (JAN/USP)
D00800  Triflupromazine hydrochloride (JAN/USP)
D00817  Bupropion hydrochloride (JAN/USP)
D00826  Tranylcypromine sulfate (USP)
D00987  Cabergoline (JP18/USP/INN)
D01041  Sparteine (INN)
D01044  Flupentixol (INN)
D01051  Spiperone (JAN/USAN)
D01097  Lazabemide hydrochloride (JAN/USAN)
D01101  Bromperidol (JAN/USAN/INN)
D01130  Thiethylperazine maleate (JAN/USP)
D01152  Oxethazaine (JP18/USAN)
D01164  Aripiprazole (JAN/USP/INN)
D01176  Blonanserin (JAN/INN)
D01226  Sulpiride (JP18/USAN/INN)
D01243  Prilocaine hydrochloride (USP)
D01259  Flopropione (JP18/INN)
D01287  Levobupivacaine hydrochloride (JAN/USAN)
D01296  Methylphenidate hydrochloride (JAN/USP)
D01321  Zotepine (JAN/INN)
D01326  Aprindine hydrochloride (JP18/USAN)
D01348  Terguride (JAN/INN)
D01412  Perazine maleate (JAN)
D01447  Thioproperazine mesilate (JAN)
D01448  Trifluoperazine maleate (JAN)
D01450  Bupivacaine hydrochloride (USP)
D01455  Cifenline succinate (USAN)
D01462  Lisuride maleate (JAN)
D01468  Nemonapride (JAN/INN)
D01477  Opipramol hydrochloride (JAN/USAN)
D01482  Pipamperone hydrochloride (JAN)
D01485  Propericiazine (JAN)
D01505  Talipexole hydrochloride (JAN)
D01520  Levomepromazine hydrochloride (JAN/USAN)
D01522  Tiapride hydrochloride (JP18)
D01548  Mosapramine hydrochloride (JAN)
D01653  Benserazide hydrochloride (JP18)
D01742  Clebopride malate (JP18)
D01745  Domperidone (JP18/USAN/INN)
D01768  Benoxinate hydrochloride (USP)
D01785  Pirmenol hydrochloride hydrate (JAN)
D01860  Perazine dimalonate (JAN)
D01888  Safrazine hydrochloride (JAN)
D01898  Haloperidol decanoate (JAN/USP)
D01903  Docarpamine (JAN/INN)
D01939  Ziprasidone hydrochloride (USP)
D02004  Apomorphine hydrochloride (USP)
D02022  Prochlorperazine mesilate (JAN)
D02037  Perphenazine maleate (JP18)
D02074  Amphetamine sulfate (USP)
D02078  Dextroamphetamine sulfate (USP)
D02086  Lidocaine hydrochloride (JAN/USP)
D02088  Tocainide hydrochloride (USP)
D02096  Fosphenytoin sodium (USP)
D02100  Ziprasidone mesylate (USAN)
D02102  Methadone hydrochloride (JAN/USP)
D02103  Phenytoin sodium (USP)
D02162  Chlorprothixene hydrochloride (JAN)
D02163  Fluphenazine maleate (JAN)
D02182  Cocaine hydrochloride (JP18/USP)
D02208  Sultopride hydrochloride (JAN)
D02213  Metoclopramide hydrochloride (JAN)
D02220  Dibucaine hydrochloride (JP18/USP)
D02236  Flupentixol dihydrochloride (JAN)
D02239  Sparteine sulfate (JAN/USAN)
D02242  Methamphetamine hydrochloride (JP18/USP)
D02248  Levomepromazine maleate (JP18/USAN)
D02272  Quinidine sulfate (USP)
D02340  Loxapine (USAN/INN)
D02354  Thiethylperazine (USAN/INN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02562  Rasagiline mesylate (USAN)
D02563  Befloxatone (INN)
D02564  Pargyline hydrochloride (USAN)
D02571  Sibutramine hydrochloride (USP)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D02581  Cimoxatone (INN)
D02604  Acepromazine maleate (USP)
D02608  Perazine fendizoate (JAN)
D02609  Prochlorperazine edisylate (USP)
D02610  Thiethylperazine malate (JAN)
D02612  Thiothixene hydrochloride (USP)
D02613  Clopenthixol (USAN)
D02622  Pipamperone (USAN/INN)
D02625  Trifluperidol (USAN/INN)
D02626  Bromperidol decanoate (USAN)
D02627  Benperidol (USAN/INN)
D02634  Alentemol hydrobromide (USAN)
D02644  Carphenazine maleate (USAN)
D02656  Fananserin (USAN/INN)
D02666  Iloperidone (USAN/INN)
D02671  Mesoridazine (USAN/INN)
D02675  Ocaperidone (USAN)
D02676  Oxiperomide (USAN/INN)
D02680  Pipotiazine palmitate (USAN)
D02688  Tiospirone hydrochloride (USAN)
D02696  Talampanel (INN)
D02729  Itopride hydrochloride (JAN)
D02762  Actisomide (USAN/INN)
D02775  Adrogolide hydrochloride (USAN)
D02780  Acamprosate calcium (JAN/USAN)
D02991  Articaine hydrochloride (JAN/USP)
D02995  Asenapine maleate (JAN/USAN)
D03082  Benserazide (USAN/INN)
D03153  Brasofensine maleate (USAN)
D03165  Bromocriptine (USAN/INN)
D03214  Aplindore fumarate (USAN)
D03215  Armodafinil (USAN/INN)
D03239  Ladostigil tartrate (USAN)
D03241  Nitecapone (INN)
D03248  Clorgiline (INN)
D03274  Chlorpromazine hibenzate (JAN)
D03409  Caroxazone (USAN/INN)
D03492  Cifenline (USAN)
D03494  Ciladopa hydrochloride (USAN)
D03534  Clebopride (USAN)
D03556  Zuclopenthixol (INN)
D03721  Dexmethylphenidate hydrochloride (USAN)
D03731  Selegiline (USAN/INN)
D03733  Mofegiline hydrochloride (USAN)
D03740  Dextroamphetamine (USAN)
D03801  Diethylpropion hydrochloride (USP)
D03878  Dizocilpine maleate (USAN)
D03891  Dopexamine (USAN/INN)
D03892  Dopexamine hydrochloride (USAN)
D03937  Ecopipam hydrochloride (USAN)
D03991  Encainide hydrochloride (USAN)
D04034  Chlorpromazine phenolphthalinate (JAN)
D04038  Perphenazine fendizoate (JAN)
D04048  Ropivacaine hydrochloride (USP)
D04092  Etryptamine acetate (USAN)
D04095  Etidocaine (USAN/INN)
D04097  Etilevodopa (USAN/INN)
D04131  Farampator (USAN/INN)
D04308  Gavestinel (USAN/INN)
D04488  Ibopamine (USAN/INN)
D04521  Indecainide hydrochloride (USAN)
D04681  Lazabemide (USAN/INN)
D04693  Lergotrile (USAN/INN)
D04694  Lergotrile mesylate (USAN)
D04728  Licostinel (USAN/INN)
D04747  Lisdexamfetamine dimesylate (USAN)
D04774  Lorajmine hydrochloride (USAN)
D04820  Lurasidone hydrochloride (JAN/USAN)
D04965  Perphenazine hydrochloride
D04997  Methyldopate hydrochloride (USP)
D04999  Methylphenidate (USAN/INN)
D05008  Metoclopramide hydrochloride (USP)
D05010  Metopimazine (USAN/INN)
D05033  Milacemide hydrochloride (USAN)
D05039  Minaprine (USAN/INN)
D05040  Minaprine hydrochloride (USAN)
D05119  Napamezole hydrochloride (USAN)
D05124  Naxagolide hydrochloride (USAN)
D05339  Paliperidone (JAN/USP/INN)
D05340  Paliperidone palmitate (JAN/USAN)
D05454  Phenmetrazine hydrochloride (USP)
D05458  Phentermine (USAN/INN)
D05459  Phentermine hydrochloride (USP)
D05575  Pramipexole (USAN/INN)
D05663  Pyrovalerone hydrochloride (USAN)
D05677  Quinelorane hydrochloride (USAN)
D05682  Quinpirole hydrochloride (USAN)
D05692  Radafaxine hydrochloride (USAN)
D05768  Rotigotine (JAN/USAN/INN)
D05775  Rufinamide (JAN/USP/INN)
D05804  Sarizotan hydrochloride (USAN)
D05832  Sibenadet hydrochloride (USAN)
D05891  Sonepiprazole mesylate (USAN)
D06172  Tocainide (USAN/INN)
D06203  Transcainide (USAN/INN)
D06204  Traxoprodil mesylate (USAN)
D06517  Pirmenol hydrochloride (USAN)
D06566  Bifeprunox (USAN/INN)
D06567  Bifeprunox mesylate (USAN)
D06623  Olanzapine pamoate (USAN)
D06656  Tezampanel (USAN)
D07058  Acamprosate (INN)
D07065  Acepromazine (INN)
D07101  Bromopride (INN)
D07102  Alizapride (INN)
D07217  Quinagolide (INN/BAN)
D07305  Piribedil (INN)
D07306  Budipine (INN)
D07309  Melperone (INN)
D07310  Amisulpride (INN)
D07312  Levosulpiride (INN)
D07316  Captodiame (BAN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D07441  Amantadine (INN)
D07444  Amfepramone (INN)
D07445  Amfetamine (INN)
D07460  Apomorphine (BAN)
D07468  Articaine (INN)
D07514  Benzfetamine (INN)
D07515  Benzfetamine hydrochloride
D07552  Bupivacaine (USAN/INN)
D07563  Alizapride hydrochloride
D07589  Budipine hydrochloride
D07591  Bupropion (INN)
D07593  Buspirone (INN)
D07595  Fosphenytoin sodium hydrate (JAN)
D07678  Chloroprocaine (INN)
D07686  Chlorprothixene acetate
D07687  Chlorprothixene citrate
D07806  Dexmethylphenidate (INN)
D07835  Dihydroergocryptine
D07836  Dihydroergocryptine mesilate
D07868  Domperidone maleate
D07870  Dopamine (INN)
D07894  Encainide (INN)
D07938  Bupropion hydrobromide (USAN)
D07946  Fenoldopam (INN)
D07962  Flecainide (INN)
D07976  Flupentixol decanoate
D07977  Fluphenazine (INN)
D07993  Fosphenytoin (INN)
D08035  Haloperidol lactate
D08057  Ibopamine hydrochloride
D08085  Iproniazid phosphate
D08094  Itopride (INN)
D08116  Levobupivacaine (INN)
D08121  Levomethadone (INN)
D08122  Levomethadone hydrochloride
D08127  Lidocaine hydrochloride monohydrate
D08130  Lisdexamfetamine (INN)
D08132  Lisuride (INN)
D08148  Loxapine hydrochloride
D08172  Melperone hydrochloride
D08181  Mepivacaine (INN)
D08187  Metamfetamine (INN)
D08195  Methadone (BAN)
D08215  Mexiletine (INN)
D08226  Molindone (INN)
D08235  Mosapramine (INN)
D08297  Opipramol (INN)
D08311  Oxetacaine hydrochloride
D08319  Oxybuprocaine (INN)
D08339  Pergolide (INN)
D08341  Perphenazine decanoate
D08342  Perphenazine enantate
D08349  Phenelzine (BAN)
D08369  Polyphloroglucinol phosphate
D08385  Pipotiazine (INN)
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08394  Pirmenol (INN)
D08407  Pramocaine (INN)
D08421  Procainamide (INN)
D08422  Procaine (INN)
D08430  Promazine (INN)
D08435  Propafenone (INN)
D08453  Pargyline (INN)
D08456  Quetiapine (INN)
D08457  Quinagolide hydrochloride (BAN)
D08458  Quinidine (BAN)
D08459  Quinidine phenylethylbarbiturate
D08469  Rasagiline (USAN/INN)
D08489  Ropinirole (USAN/INN)
D08490  Ropivacaine (INN)
D08513  Sibutramine (INN)
D08549  Sultopride (INN)
D08558  Talipexole (INN)
D08575  Tetrabenazine (JAN/INN)
D08585  Thioproperazine (INN)
D08590  Tiapride (INN)
D08625  Tranylcypromine (INN)
D08636  Trifluoperazine (INN)
D08637  Trifluperidol hydrochloride
D08687  Ziprasidone (INN)
D08691  Zuclopenthixol acetate
D08692  Zuclopenthixol decanoate
D08693  Zuclopenthixol dihydrochloride
D08964  Perampanel (USAN)
D09035  Zonampanel (INN/USAN)
D09215  Eslicarbazepine (USAN/INN)
D09366  Pardoprunox hydrochloride (USAN)
D09397  Pardoprunox (USAN/INN)
D09612  Eslicarbazepine acetate (USAN)
D09819  Chlorpromazine tannate (JAN)
D09876  Cariprazine hydrochloride (JAN/USAN)
D09931  Mibampator (USAN/INN)
D09953  Pridopidine (USAN/INN)
D09954  Pridopidine hydrochloride (USAN)
D09997  Cariprazine (USAN/INN)
D10014  Ioflupane I 123 (USAN)
D10088  Amitifadine (USAN)
D10089  Amitifadine hydrochloride (USAN)
D10107  Dasolampanel (USAN/INN)
D10108  Dasolampanel etibutil (USAN)
D10109  Dasolampanel etibutil tosylate (USAN)
D10158  Safinamide (USAN/INN)
D10191  Safinamide mesylate (USAN)
D10309  Brexpiprazole (JAN/USAN/INN)
D10355  Aripiprazole cavoxil (USAN)
D10364  Aripiprazole lauroxil (USAN)
D10516  Aripiprazole hydrate (JAN)
D10675  Valbenazine (USAN/INN)
D10697  Centanafadine (USAN/INN)
D10698  Centanafadine hydrochloride (USAN)
D10700  Dasotraline (USAN/INN)
D10701  Deutetrabenazine (USAN/INN)
D10780  Perampanel hydrate (JAN)
D10825  Opicapone (JAN/USAN/INN)
D10829  Rasagiline tartrate
D10870  Dasotraline hydrochloride (USAN)
D10999  Valbenazine tosylate (USAN)
D11169  Lumateperone (USAN/INN)
D11170  Lumateperone tosylate (USAN)
D11172  Midomafetamine (USAN/INN)
D11224  Sembragiline (USAN/INN)
D11315  Solriamfetol (USAN)
D11328  Solriamfetol hydrochloride (USAN)
D11431  Tavapadon (USAN/INN)
D11622  Amphetamine aspartate monohydrate
D11623  Dextroamphetamine saccharate
D11769  Asenapine (INN)
D11822  Mevidalen hydroxybenzoate (USAN)
D11826  Mevidalen (USAN)
D11839  Foslevodopa (JAN/USAN/INN)
D11982  Trazpiroben (USAN/INN)
D12196  Laduviglusib (USAN)
D12214  Esmethadone (USAN)
D12215  Esmethadone hydrochloride (USAN)
D12239  Pesampator (USAN)
D12616  Bliretrigine (JAN/INN)
D12716  Mesocarb (INN)
D12766  Razpipadon (USAN/INN)
D12787  Onfasprodil (USAN/INN)
D12813  Brilaroxazine (USAN/INN)
D12814  Brilaroxazine hydrochloride (USAN)
Other DBs
GO: 0001963
Organism
Homo sapiens (human) [GN:hsa]
Gene
7054  TH; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
6570  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
6571  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
1812  DRD1; dopamine receptor D1 [KO:K04144]
1816  DRD5; dopamine receptor D5 [KO:K05840]
50632  CALY; calcyon neuron specific vesicular protein [KO:K15493]
2776  GNAQ; G protein subunit alpha q [KO:K04634]
23236  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
810  CALML3; calmodulin like 3 [KO:K02183]
805  CALM2; calmodulin 2 [KO:K02183]
808  CALM3; calmodulin 3 [KO:K02183]
801  CALM1; calmodulin 1 [KO:K02183]
163688  CALML6; calmodulin like 6 [KO:K02183]
51806  CALML5; calmodulin like 5 [KO:K02183]
91860  CALML4; calmodulin like 4 [KO:K02183]
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
5578  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
2778  GNAS; GNAS complex locus [KO:K04632]
2774  GNAL; G protein subunit alpha L [KO:K04633]
111  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
1385  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
1386  ATF2; activating transcription factor 2 [KO:K04450]
468  ATF4; activating transcription factor 4 [KO:K04374]
10488  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
90993  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
64764  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
84699  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
148327  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
9586  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
1388  ATF6B; activating transcription factor 6 beta [KO:K09049]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
84152  PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B [KO:K15494]
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
6323  SCN1A; sodium voltage-gated channel alpha subunit 1 [KO:K04833]
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
773  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
3760  KCNJ3; potassium inwardly rectifying channel subfamily J member 3 [KO:K04997]
3763  KCNJ6; potassium inwardly rectifying channel subfamily J member 6 [KO:K05000]
3765  KCNJ9; potassium inwardly rectifying channel subfamily J member 9 [KO:K05002]
3762  KCNJ5; potassium inwardly rectifying channel subfamily J member 5 [KO:K04999]
1814  DRD3; dopamine receptor D3 [KO:K04146]
1815  DRD4; dopamine receptor D4 [KO:K04147]
2770  GNAI1; G protein subunit alpha i1 [KO:K04630]
2773  GNAI3; G protein subunit alpha i3 [KO:K04630]
2771  GNAI2; G protein subunit alpha i2 [KO:K04630]
2775  GNAO1; G protein subunit alpha o1 [KO:K04534]
2782  GNB1; G protein subunit beta 1 [KO:K04536]
2783  GNB2; G protein subunit beta 2 [KO:K04537]
2784  GNB3; G protein subunit beta 3 [KO:K07825]
59345  GNB4; G protein subunit beta 4 [KO:K04538]
10681  GNB5; G protein subunit beta 5 [KO:K04539]
54331  GNG2; G protein subunit gamma 2 [KO:K07826]
2785  GNG3; G protein subunit gamma 3 [KO:K04540]
2786  GNG4; G protein subunit gamma 4 [KO:K04541]
2787  GNG5; G protein subunit gamma 5 [KO:K04542]
2788  GNG7; G protein subunit gamma 7 [KO:K04543]
94235  GNG8; G protein subunit gamma 8 [KO:K04544]
2790  GNG10; G protein subunit gamma 10 [KO:K04545]
2791  GNG11; G protein subunit gamma 11 [KO:K04546]
55970  GNG12; G protein subunit gamma 12 [KO:K04347]
51764  GNG13; G protein subunit gamma 13 [KO:K04547]
2792  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
2793  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
1813  DRD2; dopamine receptor D2 [KO:K04145]
408  ARRB1; arrestin beta 1 [KO:K04439]
409  ARRB2; arrestin beta 2 [KO:K04439]
5515  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
5516  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
5519  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
5518  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
5520  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
5521  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
5522  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
55844  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
28227  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
55012  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
5523  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
5526  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
5527  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
5528  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
5529  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
5525  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2931  GSK3A; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
2932  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
2903  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
2904  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
2890  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
2891  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
2892  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
2893  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
3798  KIF5A; kinesin family member 5A [KO:K10396]
3799  KIF5B; kinesin family member 5B [KO:K10396]
3800  KIF5C; kinesin family member 5C [KO:K10396]
9575  CLOCK; clock circadian regulator [KO:K02223] [EC:2.3.1.48]
406  BMAL1; basic helix-loop-helix ARNT like 1 [KO:K02296]
6531  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
1312  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
220074  LRTOMT; leucine rich transmembrane and O-methyltransferase domain containing [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
hsa00350  Tyrosine metabolism
hsa04020  Calcium signaling pathway
hsa04721  Synaptic vesicle cycle
hsa04724  Glutamatergic synapse
hsa05012  Parkinson disease
KO pathway
ko04728   

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Network (4)   
   KEGG NETWORK (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (132)   
   KEGG GENES (132)   
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