KEGG   PATHWAY: hsa05202
Entry
hsa05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Homo sapiens (human)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
hsa05202  Transcriptional misregulation in cancer
hsa05202

Drug
D00094  Tretinoin (JAN/USP/INN)
D10891  Capmatinib hydrochloride (USAN)
D11073  Tepotinib hydrochloride (USAN)
D11768  Pacritinib (USAN/INN)
D11889  Unesblin (USAN)
D12419  Ziftomenib (USAN/INN)
D12525  Enitociclib (USAN/INN)
D12705  Gumarontinib hydrate (JAN)
D12727  Icovamenib (USAN)
D12728  Revumenib (USAN/INN)
D12729  Revumenib citrate (USAN)
D12868  Istisociclib (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
861  RUNX1; RUNX family transcription factor 1 [KO:K08367]
1436  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
4353  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
1437  CSF2; colony stimulating factor 2 [KO:K05427]
3562  IL3; interleukin 3 [KO:K04736]
862  RUNX1T1; RUNX1 partner transcriptional co-repressor 1 [KO:K10053]
3065  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
3066  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
25942  SIN3A; SIN3 transcription regulator family member A [KO:K11644]
9611  NCOR1; nuclear receptor corepressor 1 [KO:K04650]
1050  CEBPA; CCAAT enhancer binding protein alpha [KO:K09055]
8864  PER2; period circadian regulator 2 [KO:K02633]
6688  SPI1; Spi-1 proto-oncogene [KO:K09438]
929  CD14; CD14 molecule [KO:K04391]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
2209  FCGR1A; Fc gamma receptor Ia [KO:K06498]
3728  JUP; junction plakoglobin [KO:K10056]
5371  PML; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
5914  RARA; retinoic acid receptor alpha [KO:K08527]
890  CCNA2; cyclin A2 [KO:K06627]
8900  CCNA1; cyclin A1 [KO:K06627]
1053  CEBPE; CCAAT enhancer binding protein epsilon [KO:K10051]
597  BCL2A1; BCL2 related protein A1 [KO:K02162]
7704  ZBTB16; zinc finger and BTB domain containing 16 [KO:K10055]
4609  MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377]
1848  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
6929  TCF3; transcription factor 3 [KO:K09063]
5087  PBX1; PBX homeobox 1 [KO:K09355]
51384  WNT16; Wnt family member 16 [KO:K01558]
2120  ETV6; ETS variant transcription factor 6 [KO:K03211]
51513  ETV7; ETS variant transcription factor 7 [KO:K03211]
1667  DEFA1; defensin alpha 1 [KO:K05230]
1668  DEFA3; defensin alpha 3 [KO:K05230]
1669  DEFA4; defensin alpha 4 [KO:K05230]
1670  DEFA5; defensin alpha 5 [KO:K05230]
1671  DEFA6; defensin alpha 6 [KO:K05230]
728358  DEFA1B; defensin alpha 1B [KO:K05230]
1991  ELANE; elastase, neutrophil expressed [KO:K01327] [EC:3.4.21.37]
3002  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
4297  KMT2A; lysine methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
4299  AFF1; ALF transcription elongation factor 1 [KO:K15184]
1025  CDK9; cyclin dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
904  CCNT1; cyclin T1 [KO:K15188]
905  CCNT2; cyclin T2 [KO:K15188]
4298  MLLT1; MLLT1 super elongation complex subunit [KO:K15187]
4300  MLLT3; MLLT3 super elongation complex subunit [KO:K15187]
84444  DOT1L; DOT1 like histone lysine methyltransferase [KO:K11427] [EC:2.1.1.360]
4005  LMO2; LIM domain only 2 [KO:K15612]
5090  PBX3; PBX homeobox 3 [KO:K15610]
860  RUNX2; RUNX family transcription factor 2 [KO:K09278]
4086  SMAD1; SMAD family member 1 [KO:K04676]
51274  KLF3; KLF transcription factor 3 [KO:K15605]
4208  MEF2C; myocyte enhancer factor 2C [KO:K04454]
3205  HOXA9; homeobox A9 [KO:K21950]
3206  HOXA10; homeobox A10 [KO:K17443]
221037  JMJD1C; jumonji domain containing 1C [KO:K11449] [EC:1.14.11.-]
8091  HMGA2; high mobility group AT-hook 2 [KO:K09283]
7403  KDM6A; lysine demethylase 6A [KO:K11447] [EC:1.14.11.68]
8464  SUPT3H; SPT3 homolog, SAGA and STAGA complex component [KO:K11313]
8842  PROM1; prominin 1 [KO:K06532]
2322  FLT3; fms related receptor tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
55589  BMP2K; BMP2 inducible kinase [KO:K08854] [EC:2.7.11.1]
3480  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
1027  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
5218  CDK14; cyclin dependent kinase 14 [KO:K08821] [EC:2.7.11.22]
4211  MEIS1; Meis homeobox 1 [KO:K15613]
3207  HOXA11; homeobox A11 [KO:K21951]
6495  SIX1; SIX homeobox 1 [KO:K15614]
51804  SIX4; SIX homeobox 4 [KO:K15615]
2138  EYA1; EYA transcriptional coactivator and phosphatase 1 [KO:K15616] [EC:3.1.3.48]
1031  CDKN2C; cyclin dependent kinase inhibitor 2C [KO:K06622]
3248  HPGD; 15-hydroxyprostaglandin dehydrogenase [KO:K00069] [EC:1.1.1.141]
2892  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
2530  FUT8; fucosyltransferase 8 [KO:K00717] [EC:2.4.1.68]
30012  TLX3; T cell leukemia homeobox 3 [KO:K15607]
3195  TLX1; T cell leukemia homeobox 1 [KO:K09340]
64919  BCL11B; BCL11 transcription factor B [KO:K22046]
8861  LDB1; LIM domain binding 1 [KO:K15617]
4066  LYL1; LYL1 basic helix-loop-helix family member [KO:K15604]
3087  HHEX; hematopoietically expressed homeobox [KO:K08024]
171558  PTCRA; pre T cell antigen receptor alpha [KO:K06056]
5966  REL; REL proto-oncogene, NF-kB subunit [KO:K09254]
894  CCND2; cyclin D2 [KO:K10151]
329  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
330  BIRC3; baculoviral IAP repeat containing 3 [KO:K16060]
7185  TRAF1; TNF receptor associated factor 1 [KO:K03172]
598  BCL2L1; BCL2 like 1 [KO:K04570]
942  CD86; CD86 molecule [KO:K05413]
958  CD40; CD40 molecule [KO:K03160]
604  BCL6; BCL6 transcription repressor [KO:K15618]
102723407  IGH; immunoglobulin heavy variable 4-38-2-like [KO:K06856]
4094  MAF; MAF bZIP transcription factor [KO:K09035]
3695  ITGB7; integrin subunit beta 7 [KO:K06590]
7468  NSD2; nuclear receptor binding SET domain protein 2 [KO:K11424] [EC:2.1.1.357]
440093  H3-5; H3.5 histone [KO:K11253]
3021  H3-3B; H3.3 histone B [KO:K11253]
8351  H3C4; H3 clustered histone 4 [KO:K11253]
8352  H3C3; H3 clustered histone 3 [KO:K11253]
8350  H3C1; H3 clustered histone 1 [KO:K11253]
3020  H3-3A; H3.3 histone A [KO:K11253]
8290  H3-4; H3.4 histone, cluster member [KO:K11253]
126961  H3C14; H3 clustered histone 14 [KO:K11253]
333932  H3C15; H3 clustered histone 15 [KO:K11253]
653604  H3C13; H3 clustered histone 13 [KO:K11253]
8353  H3C6; H3 clustered histone 6 [KO:K11253]
8354  H3C11; H3 clustered histone 11 [KO:K11253]
8355  H3C8; H3 clustered histone 8 [KO:K11253]
8356  H3C12; H3 clustered histone 12 [KO:K11253]
8357  H3C10; H3 clustered histone 10 [KO:K11253]
8358  H3C2; H3 clustered histone 2 [KO:K11253]
8968  H3C7; H3 clustered histone 7 [KO:K11253]
5079  PAX5; paired box 5 [KO:K09383]
7849  PAX8; paired box 8 [KO:K09293]
5468  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
6256  RXRA; retinoid X receptor alpha [KO:K08524]
6257  RXRB; retinoid X receptor beta [KO:K08525]
6258  RXRG; retinoid X receptor gamma [KO:K08526]
5546  PRCC; proline rich mitotic checkpoint control factor [KO:K13105]
7030  TFE3; transcription factor binding to IGHM enhancer 3 [KO:K09105]
1026  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
7113  TMPRSS2; transmembrane serine protease 2 [KO:K09633] [EC:3.4.21.122]
2078  ERG; ETS transcription factor ERG [KO:K09435]
5328  PLAU; plasminogen activator, urokinase [KO:K01348] [EC:3.4.21.73]
5327  PLAT; plasminogen activator, tissue type [KO:K01343] [EC:3.4.21.68]
4314  MMP3; matrix metallopeptidase 3 [KO:K01394] [EC:3.4.24.17]
4318  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
6935  ZEB1; zinc finger E-box binding homeobox 1 [KO:K09299]
7850  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
6692  SPINT1; serine peptidase inhibitor, Kunitz type 1 [KO:K15619]
2115  ETV1; ETS variant transcription factor 1 [KO:K09431]
2118  ETV4; ETS variant transcription factor 4 [KO:K15592]
2119  ETV5; ETS variant transcription factor 5 [KO:K15593]
85414  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
2005  ELK4; ETS transcription factor ELK4 [KO:K04376]
1655  DDX5; DEAD-box helicase 5 [KO:K12823] [EC:5.6.2.7]
4613  MYCN; MYCN proto-oncogene, bHLH transcription factor [KO:K09109]
4149  MAX; MYC associated factor X [KO:K04453]
4193  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
7157  TP53; tumor protein p53 [KO:K04451]
648  BMI1; BMI1 proto-oncogene, polycomb ring finger [KO:K11459]
100532731  COMMD3-BMI1; COMMD3-BMI1 readthrough [KO:K11459]
6667  SP1; Sp1 transcription factor [KO:K04684]
7709  ZBTB17; zinc finger and BTB domain containing 17 [KO:K10500]
4914  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
4804  NGFR; nerve growth factor receptor [KO:K02583]
4221  MEN1; menin 1 [KO:K14970]
2130  EWSR1; EWS RNA binding protein 1 [KO:K13209]
2313  FLI1; Fli-1 proto-oncogene, ETS transcription factor [KO:K09436]
3479  IGF1; insulin like growth factor 1 [KO:K05459]
3398  ID2; inhibitor of DNA binding 2 [KO:K17693]
7048  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
3486  IGFBP3; insulin like growth factor binding protein 3 [KO:K10138]
54738  FEV; FEV transcription factor, ETS family member [KO:K09437]
466  ATF1; activating transcription factor 1 [KO:K09053]
9915  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
472  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
4286  MITF; melanocyte inducing transcription factor [KO:K09455]
7490  WT1; WT1 transcription factor [KO:K09234]
5154  PDGFA; platelet derived growth factor subunit A [KO:K04359]
3560  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
8938  BAIAP3; BAI1 associated protein 3 [KO:K15621]
7102  TSPAN7; tetraspanin 7 [KO:K06571]
4291  MLF1; myeloid leukemia factor 1 [KO:K15622]
8013  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
8148  TAF15; TATA-box binding protein associated factor 15 [KO:K14651]
2521  FUS; FUS RNA binding protein [KO:K13098]
1649  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
1051  CEBPB; CCAAT enhancer binding protein beta [KO:K10048]
3569  IL6; interleukin 6 [KO:K05405]
64332  NFKBIZ; NFKB inhibitor zeta [KO:K14242]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
3576  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
5081  PAX7; paired box 7 [KO:K09381]
5077  PAX3; paired box 3 [KO:K09381]
2308  FOXO1; forkhead box O1 [KO:K07201]
2321  FLT1; fms related receptor tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
26039  SS18L1; SS18L1 subunit of BAF chromatin remodeling complex [KO:K15623]
6760  SS18; SS18 subunit of BAF chromatin remodeling complex [KO:K15623]
6756  SSX1; SSX family member 1 [KO:K15624]
6757  SSX2; SSX family member 2 [KO:K15625]
727837  SSX2B; SSX family member 2B [KO:K15625]
26471  NUPR1; nuclear protein 1, transcriptional regulator [KO:K15626]
79058  ASPSCR1; ASPSCR1 tether for SLC2A4, UBX domain containing [KO:K15627]
4233  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
1647  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
4616  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
10912  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
581  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
578  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
1643  DDB2; damage specific DNA binding protein 2 [KO:K10140]
51426  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
PMID:20974671
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
Reference
PMID:19059936
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Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
  Journal
Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426
Reference
PMID:10350329
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Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
  Title
Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
  Journal
Leuk Lymphoma 34:25-33 (1999)
DOI:10.3109/10428199909083377
Reference
PMID:10784387
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Ohno H, Ueda C, Akasaka T
  Title
The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
DOI:10.3109/10428190009148390
Reference
PMID:19233641
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Prensner JR, Chinnaiyan AM
  Title
Oncogenic gene fusions in epithelial carcinomas.
  Journal
Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008
Reference
PMID:19406209
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Brenner JC, Chinnaiyan AM
  Title
Translocations in epithelial cancers.
  Journal
Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
Reference
PMID:16946003
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:19422821
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Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
  Title
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022
Reference
PMID:18563191
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Kumar-Sinha C, Tomlins SA, Chinnaiyan AM
  Title
Recurrent gene fusions in prostate cancer.
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Nat Rev Cancer 8:497-511 (2008)
DOI:10.1038/nrc2402
Reference
PMID:20478527
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Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
DOI:10.1016/j.ccr.2010.03.018
Reference
PMID:21747944
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Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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Reference
PMID:17505060
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Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
DOI:10.1210/me.2006-0480
Reference
PMID:18172298
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Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352
Reference
PMID:21849159
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Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
PMID:20153925
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Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
  Title
MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
DOI:10.1016/j.canlet.2010.01.015
Reference
PMID:15644444
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Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
DOI:10.1073/pnas.0405495102
Reference
PMID:20190806
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Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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Oncogene 29:2681-90 (2010)
DOI:10.1038/onc.2010.22
Reference
PMID:20145147
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Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
DOI:10.1158/0008-5472.CAN-09-2598
Reference
PMID:17327229
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Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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PMID:21123453
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Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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Cancer Res 71:404-12 (2011)
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PMID:17024155
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Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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PMID:19075677
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Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
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Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
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PMID:19564705
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Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Endocr J 56:887-95 (2009)
DOI:10.1507/endocrj.K09E-126
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PMID:17222504
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Yang Y, Hua X
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In search of tumor suppressing functions of menin.
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Mol Cell Endocrinol 265-266:34-41 (2007)
DOI:10.1016/j.mce.2006.12.032
Reference
PMID:15826838
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Aman P
  Title
Fusion oncogenes in tumor development.
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Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009
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PMID:12527902
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Fukuma M, Okita H, Hata J, Umezawa A
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055
Reference
PMID:18648544
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Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634
Reference
PMID:17250957
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Riggi N, Stamenkovic I.
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The Biology of Ewing sarcoma.
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Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009
Reference
PMID:20490326
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Jedlicka P
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Int J Clin Exp Pathol 3:338-47 (2010)
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PMID:19738075
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Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
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Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041
Reference
PMID:12527906
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Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T
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Identification of target genes for EWS/ATF-1 chimeric transcription factor.
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Oncogene 22:41-9 (2003)
DOI:10.1038/sj.onc.1206074
Reference
PMID:15826834
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Gerald WL, Haber DA
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The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
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Semin Cancer Biol 15:197-205 (2005)
DOI:10.1016/j.semcancer.2005.01.005
Reference
PMID:18855877
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Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y
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The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
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J Pathol 217:83-93 (2009)
DOI:10.1002/path.2445
Reference
PMID:18330902
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Kim S, Lee HJ, Jun HJ, Kim J
  Title
The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
  Journal
Int J Cancer 122:2446-53 (2008)
DOI:10.1002/ijc.23379
Reference
PMID:10537274
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Sjogren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Cancer Res 59:5064-7 (1999)
Reference
PMID:15688424
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Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
  Journal
Int J Cancer 115:556-60 (2005)
DOI:10.1002/ijc.20893
Reference
PMID:18850010
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Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
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The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
  Journal
Oncogene 28:270-8 (2009)
DOI:10.1038/onc.2008.378
Reference
PMID:20863376
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Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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Mol Cancer 9:257 (2010)
DOI:10.1186/1476-4598-9-257
Reference
PMID:18457914
  Authors
Linardic CM
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
DOI:10.1016/j.canlet.2008.03.035
Reference
PMID:11863357
  Authors
Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
DOI:10.1006/geno.2002.6703
Reference
PMID:17101797
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
  Title
The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
  Journal
Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06
Reference
PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
DOI:10.1007/s12032-009-9234-8
Reference
PMID:21779514
  Authors
Rivlin N, Brosh R, Oren M, Rotter V
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
  Journal
Genes Cancer 2:466-74 (2011)
DOI:10.1177/1947601911408889
Reference
PMID:21765642
  Authors
Suzuki K, Matsubara H
  Title
Recent advances in p53 research and cancer treatment.
  Journal
J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
Related
pathway
hsa04115  p53 signaling pathway
hsa05211  Renal cell carcinoma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05221  Acute myeloid leukemia
KO pathway
ko05202   

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Genome (1)   
   KEGG GENOME (1)   
Gene (193)   
   KEGG GENES (193)   
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