PATHWAY: ko00790 Help
Entry Name Folate biosynthesis
Class Metabolism; Metabolism of cofactors and vitaminsBRITE hierarchy
Pathway map Module M00840 Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:ko00790 ]
M00841 Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:ko00790 ]
M00842 Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:ko00790 ]
M00843 L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:ko00790 ]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:ko00790 ]
M00988 PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine [PATH:ko00790 ]
Drug D00145 Trimethoprim (JAN/USP/INN)
D00433 Sulfadiazine, silver (USP)
D00447 Sulfamethoxazole (JP18/USP/INN)
D00450 Sulfisoxazole (JP18/USP)
D00488 Pyrimethamine (JAN/USP/INN)
D00580 Sulfadoxine (JAN/USP/INN)
D00587 Sulfadiazine (JAN/USP/INN)
D00870 Sulfamethizole (JP18/USP/INN)
D00871 Sulfacetamide sodium (USP)
D01047 Sulfathiazole (USP/INN)
D01141 Sulfamonomethoxine (JAN/USAN/INN)
D01142 Sulfadimethoxine (JAN/USP)
D01601 Acetylsulfamethoxazole (JAN)
D01954 Sulfaphenazole (JAN/INN)
D02001 Sulfamonomethoxine sodium (JAN)
D02387 Cycloguanil pamoate (USAN)
D02434 Sulfapyridine (USP/INN)
D02439 Sulfamethoxypyridazine (INN)
D02440 Phthalylsulfathiazole (INN)
D02487 Proguanil hydrochloride (JAN/USP)
D05023 Sulfamonomethoxine hydrate (JP18)
D05947 Sulfacetamide (USP/INN)
D05948 Sulfachlorpyridazine (USP/INN)
D05949 Sulfadiazine sodium (USP)
D05952 Sulfaquinoxaline (USP/INN)
D05956 Sulfisoxazole acetyl (USP)
D05957 Sulfisoxazole diolamine (USAN)
D06236 Trimethoprim sulfate (USP)
D07060 Succinylsulfathiazole (INN)
D08538 Sulfadimethoxine sodium (USP)
D08540 Sulfamethoxypyridazine sodium salt
D08563 Iclaprim mesylate (USAN)
D11085 Trimethoprim hydrochloride
Other DBs Orthology K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3 ]
K01724 PCBD, phhB; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96 ]
K03635 MOCS2B, moaE; molybdopterin synthase catalytic subunit [EC:2.8.1.12 ]
K03637 moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17 ]
K06897 K06897 ; 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105 ]
K07142 mptE; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3 ]
K07589 folX; D-erythro-7,8-dihydroneopterin triphosphate epimerase [EC:5.1.99.7 ]
K08310 nudB, ntpA; dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67 ]
K13818 mobAB; molybdopterin-guanine dinucleotide biosynthesis protein [EC:2.7.7.77 ]
K13939 FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15 ]
K13940 sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3 ]
K13941 folKP; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.7.6.3 2.5.1.15 ]
K15740 mptN; tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33 ]
K17487 mptB; 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [EC:3.1.4.56 ]
K18589 dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K18590 dfrA12, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K18591 dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K19643 dfrA10, dfr10; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K19644 dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3 ]
K19965 folQ; dihydroneopterin triphosphate pyrophosphohydrolase [EC:3.6.1.67 ]
K22100 trpF; 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160 ]
K22101 PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.1.2.60 4.2.3.12 ]
K24102 folCP; dihydrofolate synthase / dihydropteroate synthase
K25575 pabA; 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component II
K25578 pabB; 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component I
Compound C00119 5-Phospho-alpha-D-ribose 1-diphosphate
C01217 5,6,7,8-Tetrahydromethanopterin
C01300 6-(Hydroxymethyl)-7,8-dihydropterin
C01304 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C03684 6-Pyruvoyltetrahydropterin
C04244 6-Lactoyl-5,6,7,8-tetrahydropterin
C04807 6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04895 7,8-Dihydroneopterin 3'-triphosphate
C05922 Formamidopyrimidine nucleoside triphosphate
C05923 2,5-Diaminopyrimidine nucleoside triphosphate
C05925 Dihydroneopterin phosphate
C05927 7,8-Dihydromethanopterin
C06148 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C11355 4-Amino-4-deoxychorismate
C15522 4a-Hydroxytetrahydrobiopterin
C16675 7-Aminomethyl-7-carbaguanine
C18237 Molybdoenzyme molybdenum cofactor
C18802 Tetrahydrosarcinapterin
C19848 Adenylated molybdopterin
C19871 Guanylyl molybdenum cofactor
C20239 6-Carboxy-5,6,7,8-tetrahydropterin
C20248 7-Carboxy-7-carbaguanine
C20264 L-threo-Tetrahydrobiopterin
C20559 4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562 N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566 7,8-Dihydroneopterin 2'-phosphate
C20567 7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007 5,6,7,8-Tetrahydromonapterin
C21065 7,8-Dihydroxanthopterin
C21094 7,8-Dihydromonapterin 3'-triphosphate
C21107 4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310 (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485 Cytidylyl molybdenum cofactor
C21486 Thio-molybdenum cofactor
C21640 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference Authors Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title [Cellular Functions and Metabolic Maps] (In Japanese)
Journal Tokyo Kagaku Dojin (1997)
Reference Authors Schwarz G, Mendel RR, Ribbe MW
Title Molybdenum cofactors, enzymes and pathways.
Journal Reference Authors Hanzelmann P, Schindelin H
Title Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
Journal Reference Authors Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
Title Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
Journal Reference Authors Wuebbens MM, Rajagopalan KV
Title Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
Journal Reference Authors Werner ER, Blau N, Thony B
Title Tetrahydrobiopterin: biochemistry and pathophysiology.
Journal Reference Authors Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
Title Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
Journal Reference Authors Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
Title Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
Journal Related ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis
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