KEGG   PATHWAY: ko00790Help
Entry
ko00790                     Pathway                                

Name
Folate biosynthesis
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
ko00790  Folate biosynthesis
ko00790

Ortholog table
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:ko00790]
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF [PATH:ko00790]
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF [PATH:ko00790]
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:ko00790]
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4 [PATH:ko00790]
Disease
H00167  Phenylketonuria (PKU)
H00213  Hypophosphatasia
H00831  Primary dystonia
H01197  Dihydrofolate reductase (DHFR) deficiency
Drug
D00145  Trimethoprim (JAN/USP/INN)
D00433  Sulfadiazine, silver (USP)
D00447  Sulfamethoxazole (JP17/USP/INN)
D00450  Sulfisoxazole (JP17/USP)
D00488  Pyrimethamine (JAN/USP/INN)
D00580  Sulfadoxine (JAN/USP/INN)
D00587  Sulfadiazine (JAN/USP/INN)
D00592  Dapsone (USP)
D00870  Sulfamethizole (JP17/USP/INN)
D00871  Sulfacetamide sodium (USP)
D01047  Sulfathiazole (USP/INN)
D01141  Sulfamonomethoxine (JAN/USAN/INN)
D01142  Sulfadimethoxine (JAN/USP)
D01526  Sulfisomidine (JAN)
D01601  Acetylsulfamethoxazole (JAN)
D01954  Sulfaphenazole (JAN/INN)
D02001  Sulfamonomethoxine sodium (JAN)
D02387  Cycloguanil pamoate (USAN)
D02434  Sulfapyridine (USP/INN)
D02435  Sulfamerazine (INN)
D02437  Sulfaguanidine (INN)
D02439  Sulfamethoxypyridazine (INN)
D02440  Phthalylsulfathiazole (INN)
D02447  Succinylsulfathiazole
D02487  Proguanil hydrochloride (JAN)
D02516  Sulfamoxole (USAN/INN)
D02520  Glucosulfone (INN)
D03771  Diaveridine (USAN/INN)
D05023  Sulfamonomethoxine hydrate (JP17)
D05947  Sulfacetamide (USP/INN)
D05948  Sulfachlorpyridazine (USP/INN)
D05949  Sulfadiazine sodium (USP)
D05952  Sulfaquinoxaline (USP/INN)
D05956  Sulfisoxazole acetyl (USP)
D05957  Sulfisoxazole diolamine (USAN)
D06236  Trimethoprim sulfate (USP)
D07060  Succinylsulfathiazole (INN)
D07239  Sulfathiourea (INN)
D08337  Iclaprim (USAN/INN)
D08428  Proguanil (INN)
D08538  Sulfadimethoxine sodium (USP)
D08540  Sulfamethoxypyridazine sodium salt
D08543  Sulfanilamide (INN)
D08563  Iclaprim mesylate (USAN)
D08644  Trimethoprim lactate
Other DBs
BSID: 404
GO: 0046656
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
K01077  alkaline phosphatase [EC:3.1.3.1]
K01113  alkaline phosphatase D [EC:3.1.3.1]
K08310  dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67]
K19965  dihydroneopterin triphosphate pyrophosphohydrolase [EC:3.6.1.67]
K13939  dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3 4.1.2.25]
K13940  dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3 4.1.2.25]
K01633  7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:1.13.11.81 5.1.99.8 4.1.2.25]
K00950  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
K00796  dihydropteroate synthase [EC:2.5.1.15]
K13941  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:2.5.1.15 2.7.6.3]
K18974  dihydropteroate synthase type 1 [EC:2.5.1.15]
K18824  dihydropteroate synthase type 2 [EC:2.5.1.15]
K18825  dihydropteroate synthase type 3 [EC:2.5.1.15]
K00287  dihydrofolate reductase [EC:1.5.1.3]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:2.1.1.45 1.5.1.3]
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
K11754  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.17 6.3.2.12]
K22099  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.17 6.3.2.12]
K20457  dihydrofolate synthase [EC:6.3.2.12]
K01307  gamma-glutamyl hydrolase [EC:3.4.19.9]
K01497  GTP cyclohydrolase II [EC:3.5.4.25]
K14652  3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:3.5.4.25 4.1.99.12]
K22100  2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase [EC:4.2.1.160]
K22101  dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.2.3.12 4.1.2.60]
K01664  para-aminobenzoate synthetase component II [EC:2.6.1.85]
K01665  para-aminobenzoate synthetase component I [EC:2.6.1.85]
K13950  para-aminobenzoate synthetase [EC:2.6.1.85]
K03342  para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:4.1.3.38 2.6.1.85]
K02619  4-amino-4-deoxychorismate lyase [EC:4.1.3.38]
K18482  4-amino-4-deoxychorismate lyase [EC:4.1.3.38]
K07589  D-erythro-7,8-dihydroneopterin triphosphate epimerase [EC:5.1.99.7]
K13938  dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.3 1.5.1.50]
K01737  6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.1.2.50 4.2.3.12]
K00072  sepiapterin reductase [EC:1.1.1.153]
K00011  aldehyde reductase [EC:1.1.1.21]
K00079  carbonyl reductase 1 [EC:1.1.1.197 1.1.1.189 1.1.1.184]
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.357 1.1.1.213 1.1.1.188 1.1.1.51]
K00357  dihydropteridine reductase [EC:1.5.1.34]
K01724  4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]
K00500  phenylalanine-4-hydroxylase [EC:1.14.16.1]
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
K17745  sepiapterin reductase [EC:1.1.1.325]
K00310  pyrimidodiazepine synthase [EC:1.5.4.1]
K10026  7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
K06920  7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
K06879  7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K09457  7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
K17488  GTP cyclohydrolase IV [EC:3.5.4.39]
K17487  7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [EC:3.1.4.56]
K09739  dihydroneopterin aldolase [EC:4.1.2.25]
K07142  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
K06984  beta-ribofuranosylaminobenzene 5'-phosphate synthase [EC:2.4.2.54]
K06897  7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105]
K17364  dihydromethanopterin reductase [EC:1.5.1.47]
K18853  dihydromethanopterin reductase (acceptor) [EC:1.5.99.15]
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase [EC:6.3.2.33]
K22102  dihydroneopterin phosphate aldolase [EC:4.1.2.59]
K03639  GTP 3',8-cyclase [EC:4.1.99.22]
K03637  cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]
K20967  GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase [EC:4.6.1.17 4.1.99.22]
K03635  molybdopterin synthase catalytic subunit [EC:2.8.1.12]
K21142  MoaE-MoaD fusion protein [EC:2.8.1.12]
K03831  molybdopterin adenylyltransferase [EC:2.7.7.75]
K03638  molybdopterin adenylyltransferase [EC:2.7.7.75]
K03750  molybdopterin molybdotransferase [EC:2.10.1.1]
K15376  gephyrin [EC:2.7.7.75 2.10.1.1]
K07141  molybdenum cofactor cytidylyltransferase [EC:2.7.7.76]
K03752  molybdenum cofactor guanylyltransferase [EC:2.7.7.77]
K13818  molybdopterin-guanine dinucleotide biosynthesis protein [EC:2.7.7.77]
K15631  molybdenum cofactor sulfurtransferase [EC:2.8.1.9]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P

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