Entry Name Small cell lung cancer - Mus musculus (house mouse)
Description Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Disease Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 107986 Ddb2; damage specific DNA binding protein 2 [KO:K10140 ]
11783 Apaf1; apoptotic peptidase activating factor 1 [KO:K02084 ]
11796 Birc3; baculoviral IAP repeat-containing 3 [KO:K16060 ]
11797 Birc2; baculoviral IAP repeat-containing 2 [KO:K16060 ]
12575 Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625 ]
12576 Cdkn1b; cyclin dependent kinase inhibitor 1B [KO:K06624 ]
12579 Cdkn2b; cyclin dependent kinase inhibitor 2B [KO:K04685 ]
13197 Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
16412 Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719 ]
17873 Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
18035 Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
19645 Rb1; RB transcriptional corepressor 1 [KO:K06618 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
22029 Traf1; TNF receptor-associated factor 1 [KO:K03172 ]
22031 Traf3; TNF receptor-associated factor 3 [KO:K03174 ]
22032 Traf4; TNF receptor associated factor 4 [KO:K09848 ]
22033 Traf5; TNF receptor-associated factor 5 [KO:K09849 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
22642 Zbtb17; zinc finger and BTB domain containing 17 [KO:K10500 ]
23882 Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402 ]
27401 Skp2; S-phase kinase-associated protein 2 [KO:K03875 ]
329581 Birc7; baculoviral IAP repeat-containing 7 [KO:K16061 ]
624855 Cks1brt; CDC28 protein kinase 1b, retrogene [KO:K02219 ]
66197 Cks2; CDC28 protein kinase regulatory subunit 2 [KO:K02219 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Osada H, Takahashi T.
Title Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Journal Reference Authors Yokota J, Nishioka M, Tani M, Kohno T.
Title Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Journal Reference Authors Sanchez-Cespedes M.
Title Dissecting the genetic alterations involved in lung carcinogenesis.
Journal Reference Authors Mitsuuchi Y, Testa JR.
Title Cytogenetics and molecular genetics of lung cancer.
Journal Reference Authors Kaye FJ.
Title Molecular biology of lung cancer.
Journal Reference Authors Panani AD, Roussos C.
Title Cytogenetic and molecular aspects of lung cancer.
Journal Reference Authors Altucci L, Gronemeyer H.
Title The promise of retinoids to fight against cancer.
Journal Reference Authors Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
Title Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal Reference Authors Sartorius UA, Krammer PH.
Title Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
Journal Reference Authors Adhikary S, Eilers M.
Title Transcriptional regulation and transformation by Myc proteins.
Journal Reference Authors Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
Title A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
Journal Reference Authors Buttery RC, Rintoul RC, Sethi T.
Title Small cell lung cancer: the importance of the extracellular matrix.
Journal Reference Authors Yamada KM, Araki M.
Title Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
Journal J Cell Sci 114:2375-82 (2001)
Reference Authors Rintoul RC, Sethi T.
Title The role of extracellular matrix in small-cell lung cancer.
Journal Reference Authors Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
Title Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
Journal Reference Authors Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
Title Apoptosis and lung cancer: a review.
Journal Reference Authors Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM
Title Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.
Journal Exp Oncol 34:192-9 (2012)
Related KO pathway
