Entry |
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Name |
Cellular senescence - Rattus norvegicus (rat)
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Description |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
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Class |
Cellular Processes; Cell growth and death
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Pathway map |

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Other DBs |
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Organism |
Rattus norvegicus (rat) [GN: rno]
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Gene |
59086 | Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375] |
81809 | Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376] |
25717 | Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377] |
29357 | Smad2; mothers against decapentaplegic homolog 2 [KO:K04500] |
25631 | Smad3; mothers against decapentaplegic homolog 3 [KO:K23605] |
25164 | Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685] |
24708 | Rb1; retinoblastoma-associated protein [KO:K06618] |
684111 | E2f2; transcription factor E2F2 isoform X1 [KO:K09389] |
116651 | E2f5; transcription factor E2F5 isoform X1 [KO:K04682] |
85243 | Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153] |
170911 | Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] |
366508 | Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153] |
25513 | Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649] |
60664 | Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649] |
29741 | Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] |
114851 | Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625] |
24747 | RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751] |
24973 | RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751] |
24974 | RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751] |
24988 | RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751] |
294213 | RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751] |
309600 | RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751] |
309603 | RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751] |
309607 | RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751] |
361787 | RT1-T24-1; RT1 class I, locus T24, gene 1 [KO:K06751] |
365527 | RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751] |
368153 | RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751] |
414270 | RT1-CE14; RT1 class I, locus CE14 isoform 1 precursor [KO:K06751] |
414779 | RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751] |
414783 | RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751] |
414784 | RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751] |
414785 | RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751] |
414786 | RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751] |
414787 | RT1-M10-1; RT1 class I, locus M10, gene 1 precursor [KO:K06751] |
414789 | RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751] |
414790 | RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751] |
414791 | RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751] |
414792 | RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751] |
414793 | RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751] |
414819 | RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751] |
406194 | RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751] |
414788 | RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751] |
680842 | RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751] |
102546590 | patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751] |
499400 | RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751] |
310511 | RGD1563620; histone-binding protein RBBP4 [KO:K10752] |
25163 | Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621] |
54355 | Rassf5; ras association domain-containing protein 5 [KO:K08015] |
303024 | Fbxw11; F-box/WD repeat-containing protein 11 [KO:K03362] |
361765 | Btrc; F-box/WD repeat-containing protein 1A [KO:K03362] |
24668 | Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16] |
24669 | Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16] |
25594 | Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16] |
58960 | Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2] |
25112 | Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402] |
291005 | Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402] |
299626 | Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402] |
317389 | Ccnb3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771] |
64046 | Mre11; double-strand break repair protein MRE11 [KO:K10865] |
64012 | Rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-] |
363924 | Rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995] |
81736 | Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580] |
24484 | Igfbp3; insulin-like growth factor-binding protein 3 precursor [KO:K10138] |
24617 | Serpine1; plasminogen activator inhibitor 1 precursor [KO:K03982] |
116636 | Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205] |
29344 | Zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753] |
298765 | Zfp36l2; zinc finger protein 36, C3H1 type-like 2 [KO:K18753] |
29716 | Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851] |
66026 | Trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973] |
679906 | Trpm7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1] |
24674 | Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16] |
24675 | Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16] |
171378 | Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16] |
100361818 | Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446] |
311658 | Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332] |
361400 | Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333] |
305897 | Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334] |
25262 | Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958] |
81678 | Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959] |
25679 | Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960] |
83529 | Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862] |
83531 | Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040] |
83532 | Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041] |
294560 | Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858] |
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Compound |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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Reference |
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Authors |
Munoz-Espin D, Serrano M |
Title |
Cellular senescence: from physiology to pathology. |
Journal |
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Reference |
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Authors |
Childs BG, Durik M, Baker DJ, van Deursen JM |
Title |
Cellular senescence in aging and age-related disease: from mechanisms to therapy. |
Journal |
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Reference |
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Authors |
Sharpless NE, Sherr CJ |
Title |
Forging a signature of in vivo senescence. |
Journal |
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Reference |
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Authors |
Fridlyanskaya I, Alekseenko L, Nikolsky N |
Title |
Senescence as a general cellular response to stress: A mini-review. |
Journal |
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Reference |
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Authors |
Lujambio A |
Title |
To clear, or not to clear (senescent cells)? That is the question. |
Journal |
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Reference |
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Authors |
Di Mitri D, Alimonti A |
Title |
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer. |
Journal |
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Reference |
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Authors |
Francica P, Aebersold DM, Medova M |
Title |
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer. |
Journal |
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Reference |
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Authors |
Bartling B |
Title |
Cellular senescence in normal and premature lung aging. |
Journal |
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Reference |
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Authors |
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M |
Title |
Programmed cell senescence during mammalian embryonic development. |
Journal |
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Reference |
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Authors |
Herranz N, Gallage S, Gil J |
Title |
TORn about SASP regulation. |
Journal |
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Reference |
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Authors |
Martin N, Bernard D |
Title |
Calcium signaling and cellular senescence. |
Journal |
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Reference |
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Authors |
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N |
Title |
Calcium homeostasis in cancer: A focus on senescence. |
Journal |
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Reference |
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Authors |
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA |
Title |
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype. |
Journal |
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Reference |
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Authors |
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ |
Title |
Ras signaling through RASSF proteins. |
Journal |
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Reference |
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Authors |
Barnoud T, Schmidt ML, Donninger H, Clark GJ |
Title |
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence. |
Journal |
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Reference |
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Authors |
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ |
Title |
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. |
Journal |
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Reference |
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Authors |
Cao X, Li M |
Title |
A New Pathway for Senescence Regulation. |
Journal |
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Reference |
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Authors |
Gire V, Dulic V |
Title |
Senescence from G2 arrest, revisited. |
Journal |
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Reference |
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Authors |
Mowla SN, Lam EW, Jat PS |
Title |
Cellular senescence and aging: the role of B-MYB. |
Journal |
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Reference |
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Authors |
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I |
Title |
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. |
Journal |
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Reference |
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Authors |
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I |
Title |
Redox regulation of SIRT1 in inflammation and cellular senescence. |
Journal |
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Related pathway |
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KO pathway |
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