KEGG   PATHWAY: bta04713Help
Entry
bta04713                    Pathway                                

Name
Circadian entrainment - Bos taurus (cow)
Description
Circadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhythms are synchronized to environmental cues. In mammals, a master clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and may synchronize circadian oscillators in peripheral tissues. Light signal is the dominant synchronizer for master SCN clock. Downstream from the retina, glutamate and PACAP are released and trigger the activation of signal transduction cascades, including CamKII and nNOS activity, cAMP- and cGMP-dependent protein kinases, and mitogen-activated protein kinase (MAPK). Of non-photic entrainment, important phase shifting capabilities have been found for melatonin, which inhibits light-induced phase shifts through inhibition of adenylate cyclase (AC). Multiple entrainment pathways converge into CREB regulation. In turn, phosphorylated CREB activates clock gene expression.
Class
Organismal Systems; Environmental adaptation
BRITE hierarchy
Pathway map
bta04713  Circadian entrainment
bta04713

Ortholog table
Other DBs
GO: 0009649
Organism
Bos taurus (cow) [GN:bta]
Gene
100336579  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
524212  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
537804  GRIN2B; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
535158  GRIN2C; glutamate receptor ionotropic, NMDA 2C precursor [KO:K05211]
618181  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
326597  CALM; calmodulin [KO:K02183]
520277  CALM3; calmodulin [KO:K02183]
617095  CALM1; calmodulin [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
100297344  CALM2; calmodulin [KO:K02183]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
104973792  calcium-dependent protein kinase 10 [KO:K02183]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
536132  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
504408  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100139857  RYR1; ryanodine receptor 1 [KO:K04961]
537376  RYR2; ryanodine receptor 2 isoform X3 [KO:K04962]
539899  RYR3; ryanodine receptor 3 [KO:K04963]
539686  NOS1AP; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [KO:K16513]
507449  RASD1; dexamethasone-induced Ras-related protein 1 [KO:K07843]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
539521  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
281792  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor [KO:K04540]
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor [KO:K04542]
104968964  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor [KO:K04546]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [KO:K04347]
529425  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor [KO:K04549]
529618  GRIA1; glutamate receptor 1 precursor [KO:K05197]
614283  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
534626  GRIA3; glutamate receptor 3 precursor [KO:K05199]
529904  GRIA4; glutamate receptor 4 precursor [KO:K05200]
282411  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
282412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
282413  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
615187  ADCYAP1; pituitary adenylate cyclase-activating polypeptide precursor [KO:K05262]
319095  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor precursor [KO:K04587]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
531747  adenylate cyclase type 10 isoform X7 [KO:K11265] [EC:4.6.1.1]
521844  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
613600  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
281216  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
282433  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
282004  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
533330  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
408015  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
528665  MTNR1B; melatonin receptor type 1B [KO:K04286]
539948  MTNR1A; melatonin receptor type 1A [KO:K04285]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
526088  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
539844  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
520743  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
614969  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
516318  PER1; period circadian protein homolog 1 [KO:K21944]
512237  PER2; period circadian protein homolog 2 [KO:K02633]
614154  PER3; LOW QUALITY PROTEIN: period circadian protein homolog 3 [KO:K21945]
280795  FOS; proto-oncogene c-Fos [KO:K04379]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
C01598  Melatonin
Reference
  Authors
Brown TM, Piggins HD
  Title
Electrophysiology of the suprachiasmatic circadian clock.
  Journal
Prog Neurobiol 82:229-55 (2007)
DOI:10.1016/j.pneurobio.2007.05.002
Reference
  Authors
Dickson L, Finlayson K
  Title
VPAC and PAC receptors: From ligands to function.
  Journal
Pharmacol Ther 121:294-316 (2009)
DOI:10.1016/j.pharmthera.2008.11.006
Reference
  Authors
Golombek DA, Rosenstein RE
  Title
Physiology of circadian entrainment.
  Journal
Physiol Rev 90:1063-102 (2010)
DOI:10.1152/physrev.00009.2009
Reference
  Authors
Dubocovich ML, Markowska M
  Title
Functional MT1 and MT2 melatonin receptors in mammals.
  Journal
Endocrine 27:101-10 (2005)
DOI:10.1385/ENDO:27:2:101
Reference
  Authors
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J
  Title
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.
  Journal
Pharmacol Rev 62:343-80 (2010)
DOI:10.1124/pr.110.002832
Reference
  Authors
Hardeland R
  Title
Melatonin: signaling mechanisms of a pleiotropic agent.
  Journal
Biofactors 35:183-92 (2009)
DOI:10.1002/biof.23
Reference
  Authors
Golombek DA, Ferreyra GA, Agostino PV, Murad AD, Rubio MF, Pizzio GA, Katz ME, Marpegan L, Bekinschtein TA
  Title
From light to genes: moving the hands of the circadian clock.
  Journal
Front Biosci 8:s285-93 (2003)
Reference
  Authors
Mertens I, Husson SJ, Janssen T, Lindemans M, Schoofs L
  Title
PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
  Journal
Peptides 28:1775-83 (2007)
DOI:10.1016/j.peptides.2007.05.005
Reference
  Authors
Kim DY, Choi HJ, Kim JS, Kim YS, Jeong DU, Shin HC, Kim MJ, Han HC, Hong SK, Kim YI
  Title
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock.
  Journal
Eur J Neurosci 21:1215-22 (2005)
DOI:10.1111/j.1460-9568.2005.03950.x
Reference
  Authors
Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA
  Title
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
  Journal
Neurochem Int 44:617-25 (2004)
DOI:10.1016/j.neuint.2003.09.005
Reference
  Authors
Ferreyra GA, Golombek DA
  Title
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
  Journal
Am J Physiol Regul Integr Comp Physiol 280:R1348-55 (2001)
DOI:10.1152/ajpregu.2001.280.5.R1348
Reference
  Authors
Butcher GQ, Lee B, Cheng HY, Obrietan K
  Title
Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism.
  Journal
J Neurosci 25:5305-13 (2005)
DOI:10.1523/JNEUROSCI.4361-04.2005
Reference
  Authors
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
  Title
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
  Journal
Brain Res 838:131-5 (1999)
DOI:10.1016/S0006-8993(99)01719-9
Reference
  Authors
Diaz-Munoz M, Dent MA, Granados-Fuentes D, Hall AC, Hernandez-Cruz A, Harrington ME, Aguilar-Roblero R
  Title
Circadian modulation of the ryanodine receptor type 2 in the SCN of rodents.
  Journal
Neuroreport 10:481-6 (1999)
Reference
  Authors
Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH
  Title
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
  Journal
Neuron 28:183-93 (2000)
DOI:10.1016/S0896-6273(00)00095-7
Reference
  Authors
Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, Ohhata T, Araki R, Abe M
  Title
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
  Journal
Brain Res Mol Brain Res 110:1-6 (2003)
DOI:10.1016/S0169-328X(02)00543-0
Reference
  Authors
Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
  Title
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
  Journal
J Neurosci 26:12984-95 (2006)
DOI:10.1523/JNEUROSCI.4253-06.2006
KO pathway
ko04713   

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