KEGG   PATHWAY: rno04062
Entry
rno04062                    Pathway                                
Name
Chemokine signaling pathway - Rattus norvegicus (rat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
rno04062  Chemokine signaling pathway
rno04062

Other DBs
GO: 0070098
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100124593  Cxcr6; C-X-C chemokine receptor type 6 [KO:K04191]
114105  Cxcl2; C-X-C motif chemokine 2 precursor [KO:K05505]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114492  Ccl28; C-C motif chemokine 28 precursor [KO:K05513]
114553  Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
114858  Shc3; SHC-transforming protein 3 [KO:K17448]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116637  Ccl4; C-C motif chemokine 4 precursor [KO:K12964]
117027  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
117029  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117518  Ccl17; C-C motif chemokine 17 precursor [KO:K21083]
117551  Ccl22; C-C motif chemokine 22 precursor [KO:K21095]
134484121  [KO:K00922] [EC:2.7.1.153]
170538  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171054  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
171056  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
171337  Rap1b; ras-related protein Rap-1b precursor [KO:K07836]
171371  Xcl1; lymphotactin precursor [KO:K05507]
171551  Cxcl3; C-X-C motif chemokine 3 precursor [KO:K05505]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
24514  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
24525  Kras; GTPase KRas [KO:K07827]
245920  Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
24605  Nras; GTPase NRas [KO:K07828]
246358  Ppbp; platelet basic protein precursor [KO:K10029]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
246759  Cxcl9; C-X-C motif chemokine 9 precursor [KO:K05416]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
24772  Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25126  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
25156  Vav1; proto-oncogene vav [KO:K05730]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25238  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
25326  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
25372  Grk3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
25387  Arrb1; beta-arrestin-1 [KO:K04439]
25388  Arrb2; beta-arrestin-2 [KO:K04439]
25414  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform 3 [KO:K05726]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25522  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
25542  Ccl3; C-C motif chemokine 3 precursor [KO:K05408]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25734  Hck; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
282832  Ccr9; C-C chemokine receptor type 9 [KO:K04184]
287561  Ccl7; C-C motif chemokine 7 precursor [KO:K05509]
287562  Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624]
287673  Ccr7; C-C chemokine receptor type 7 precursor [KO:K04182]
287910  Ccl6; C-C motif chemokine 6 precursor [KO:K05510]
287942  Crkl; crk-like protein [KO:K04438]
288593  Ccl24; C-C motif chemokine 24 precursor [KO:K21097]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
293621  Hras; GTPase HRas [KO:K02833]
29363  Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
29385  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
29397  Ccl11; eotaxin precursor [KO:K16597]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
29431  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
294515  Foxo3; forkhead box protein O3 [KO:K09408]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
295347  Rap1a; ras-related protein Rap-1A [KO:K04353]
295378  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
29538  Ccl20; C-C motif chemokine 20 precursor [KO:K14625]
296603  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
298006  Ccl21; C-C motif chemokine 21 precursor [KO:K16062]
298947  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
301066  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
301086  Xcr1; chemokine XC receptor 1 [KO:K04193]
301088  Ccr1l1; C-C chemokine receptor 1-like protein 1 [KO:K04176]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
304109  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
305236  Cxcl11; C-X-C motif chemokine 11 precursor [KO:K12672]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
306748  Cxcl14; C-X-C motif chemokine 14 precursor [KO:K10033]
308163  Ccr6; C-C chemokine receptor type 6 [KO:K04181]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
311647  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
314612  Shc2; SHC-transforming protein 2 [KO:K17447]
317371  Was; actin nucleation-promoting factor WAS [KO:K05747]
360579  Ccl9; C-C motif chemokine 9 precursor [KO:K22671]
360750  Ccl25; C-C motif chemokine 25 precursor [KO:K13072]
360820  Pxn; paxillin isoform 1 [KO:K05760]
360918  Pf4; platelet factor 4 precursor [KO:K05407]
361251  Elmo1; engulfment and cell motility protein 1 [KO:K12366]
361714  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
362505  Ccl27; C-C motif chemokine 27 [KO:K16598]
362506  Ccl19; C-C motif chemokine 19 precursor [KO:K05512]
363577  Itk; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
363682  Ccr10; C-C chemokine receptor type 10 [KO:K04185]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
497931  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
497932  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
497942  Cxcl16; C-X-C motif chemokine 16 precursor [KO:K10035]
498335  Cxcl13; C-X-C motif chemokine 13 isoform 2 precursor [KO:K10032]
50646  Ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
50686  Gsk3a; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
54245  Crk; adapter molecule crk [KO:K04438]
54258  Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175]
57301  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
59075  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
59076  Grk6; G protein-coupled receptor kinase 6 isoform c [KO:K08291] [EC:2.7.11.16]
59077  Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
60463  Ccr2; C-C chemokine receptor type 2 [KO:K04177]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
60665  Cxcl6; C-X-C motif chemokine 5 precursor [KO:K05506]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
679845  Shc4; SHC-transforming protein 4 [KO:K17449]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
685958  Ccl26; C-C motif chemokine 26 precursor [KO:K21096]
688319  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
688605  Ccl1; C-C motif chemokine 1 precursor [KO:K05514]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
79113  Fgr; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
81503  Cxcl1; growth-regulated alpha protein precursor [KO:K05505]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81515  Lyn; tyrosine-protein kinase Lyn isoform A [KO:K05854] [EC:2.7.10.2]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81760  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
81780  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
81918  Pard3; partitioning defective 3 homolog [KO:K04237]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
84475  Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
85385  Shc1; SHC-transforming protein 1 isoform b [KO:K06279]
89808  Cx3cl1; fractalkine precursor [KO:K05508]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
rno04010  MAPK signaling pathway
rno04060  Cytokine-cytokine receptor interaction
rno04120  Ubiquitin mediated proteolysis
rno04630  JAK-STAT signaling pathway
rno04670  Leukocyte transendothelial migration
rno04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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