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Drug Identifiers

The KEGG DRUG D number is an identifier to distinguish drugs as chemical substances, which is used to integrate approved drugs in Japan, USA and Europe. The D numbers are linked to drug classifications, such as WHO's ATC classification. In KEGG MEDICUS all drug products in the USA (and in Japan in the Japanese version) are given D numbers and organized in the following hierarchy.
Drug classification (ATC code, etc.)
Chemical substance (KEGG DG number and D number)
Drug label (DailyMed setId)
Drug product (NDC)


KEGG D number
Represents the chemical structure (or the chemical component of a mixture).
A KEGG identifier consisting of the prefix D followed by a five-digit number.
(Example) D01441 Imatinib mesylate (Gleevec)

KEGG DG number
Represents the chemical group of essentialy the same active ingredients with minor differences of salts and hydration states.
(Example) DG00710 Imatinib

ATC code
WHO's Anatomical Therapeutic Chemical Classification.
A five-level classification system.
(Example) ATC code L01EA01 for imatinib
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EA BCR-ABL tyrosine kinase inhibitors
L01EA01 Imatinib

DailyMed setId
A unique identifier for the FDA labels (package inserts) in the DailyMed database.
Consisting of 36 characters including four hyphens.
(Example) 211ef2da-2868-4a77-8055-1cb2cd78e24b GLEEVEC (Novartis)

NDC (National Drug Code)
A unique three-segment number for human drugs in the USA.
Consisting of the labeler code, the product code and the package code.
(Product example) 0078-0401 GLEEVEC
(Package example) 0078-0401-34 GLEEVEC 90 TABLET in 1 BOTTLE

Note that only the first two segments of the NDC code are used in KEGG MEDICUS.


Last updated: August 10, 2021