PCIDB

KNApSAcK Metabolite C00001429

Metabolite

KNApSAcK Entry

id C00001429
Name Serotonin / Enteramin / Enteramine / DS substance / Thrombotonin / Thrombocytin / 5-Hydroxytryptamine
CAS RN 50-67-9
Standard InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Standard InChI (Main Layer) InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1910

Link

ChEMBL

By standard InChI CHEMBL39
By standard InChI Main Layer CHEMBL39 CHEMBL1628597

KEGG

By LinkDB C00780

CTD

By CAS RN D012701

Human Protein / Gene in interaction

78 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL39 CHEMBL1614110 (1) CHEMBL1741321 (2)
1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL39 CHEMBL1908082 (1)
3 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme CHEMBL39 CHEMBL1908091 (2)
1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL39 CHEMBL2076309 (1) CHEMBL2077779 (1)
CHEMBL2077780 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL39 CHEMBL1794499 (1)
2 / 0
Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 Unclassified protein CHEMBL39 CHEMBL1292491 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL39 CHEMBL669035 (1) CHEMBL669037 (1)
CHEMBL937842 (1) CHEMBL937843 (1)
CHEMBL2342847 (2) CHEMBL2343276 (2)
CHEMBL2343280 (1) CHEMBL2343284 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL39 CHEMBL2016146 (1)
0 / 3
Q13639 5-hydroxytryptamine receptor 4 Serotonin receptor CHEMBL39 CHEMBL936489 (1) CHEMBL979354 (1)
CHEMBL962554 (1) CHEMBL962555 (1)
CHEMBL1053069 (1) CHEMBL1053071 (1)
CHEMBL1053072 (1)
0 / 0
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL39 CHEMBL881969 (1)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL39 CHEMBL885804 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL39 CHEMBL885803 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL39 CHEMBL889439 (1)
0 / 0
P49286 Melatonin receptor type 1B Melatonin receptor CHEMBL39 CHEMBL713140 (1)
0 / 1
P23415 Glycine receptor subunit alpha-1 GLR alpha CHEMBL39 CHEMBL896290 (1)
1 / 1
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL39 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL39 CHEMBL869780 (1) CHEMBL889437 (1)
CHEMBL887924 (1) CHEMBL932482 (1)
CHEMBL970751 (1) CHEMBL953312 (1)
CHEMBL1017972 (1) CHEMBL1067709 (1)
CHEMBL1106967 (1) CHEMBL2156561 (1)
CHEMBL2318049 (1)
1 / 2
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor CHEMBL39 CHEMBL883242 (1) CHEMBL616962 (1)
CHEMBL616530 (1) CHEMBL616538 (1)
CHEMBL616449 (1) CHEMBL616463 (1)
CHEMBL616623 (1) CHEMBL616629 (1)
CHEMBL616645 (1) CHEMBL616661 (1)
CHEMBL616807 (1) CHEMBL616862 (1)
CHEMBL616864 (1) CHEMBL829900 (1)
CHEMBL983896 (1) CHEMBL947380 (2)
CHEMBL965237 (1) CHEMBL1817463 (1)
0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor CHEMBL39 CHEMBL1628597 CHEMBL620823 (1) CHEMBL618164 (1)
CHEMBL619855 (1) CHEMBL983901 (1)
CHEMBL947387 (2) CHEMBL991220 (1)
CHEMBL960152 (1) CHEMBL1629076 (1)
CHEMBL1817469 (1)
0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor CHEMBL39 CHEMBL620714 (1) CHEMBL618085 (1)
CHEMBL983899 (1) CHEMBL947385 (2)
CHEMBL1817467 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL39 CHEMBL1614027 (1) CHEMBL1741325 (2)
0 / 1
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL39 CHEMBL1908093 (1)
0 / 0
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL39 CHEMBL671063 (1) CHEMBL672213 (1)
CHEMBL937844 (1) CHEMBL937845 (1)
CHEMBL2342830 (2) CHEMBL2343279 (1)
CHEMBL2343283 (1)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL39 CHEMBL2016145 (1)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL39 CHEMBL887925 (1) CHEMBL1067710 (1)
0 / 0
P05164 Myeloperoxidase Enzyme CHEMBL39 CHEMBL2352940 (1)
1 / 2
P28566 5-hydroxytryptamine receptor 1E Serotonin receptor CHEMBL39 CHEMBL1628597 CHEMBL616848 (1) CHEMBL1629206 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL39 CHEMBL889441 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL39 CHEMBL932484 (1)
1 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL39 CHEMBL1738606 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL39 CHEMBL1908090 (1)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL39 CHEMBL670710 (1) CHEMBL670711 (1)
1 / 0
P46098 5-hydroxytryptamine receptor 3A NS CHEMBL39 CHEMBL858288 (1) CHEMBL618047 (1)
CHEMBL619765 (1) CHEMBL619771 (1)
CHEMBL618132 (1) CHEMBL618133 (1)
CHEMBL618134 (1) CHEMBL618135 (1)
CHEMBL618136 (1) CHEMBL896288 (2)
CHEMBL1648624 (1) CHEMBL1648628 (1)
0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL39 CHEMBL617172 (1) CHEMBL617371 (1)
CHEMBL617407 (1) CHEMBL617774 (1)
CHEMBL617778 (1) CHEMBL863543 (1)
CHEMBL854089 (1) CHEMBL854092 (1)
CHEMBL854095 (1) CHEMBL926600 (1)
CHEMBL921967 (1) CHEMBL921970 (1)
CHEMBL957592 (1) CHEMBL957593 (1)
CHEMBL1041005 (1) CHEMBL1041006 (1)
CHEMBL2025265 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL39 CHEMBL869779 (1) CHEMBL889435 (1)
CHEMBL887923 (1) CHEMBL932481 (1)
CHEMBL970750 (1) CHEMBL965608 (1)
CHEMBL1067708 (1) CHEMBL2156560 (1)
CHEMBL2318048 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL39 CHEMBL1064098 (1)
4 / 2
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL39 CHEMBL1065539 (1)
2 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL39 CHEMBL618118 (1) CHEMBL618122 (1)
CHEMBL618124 (1) CHEMBL619955 (1)
CHEMBL828233 (1) CHEMBL983900 (1)
CHEMBL947386 (2) CHEMBL1073455 (1)
CHEMBL1817468 (1)
0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha CHEMBL39 CHEMBL896286 (1)
0 / 0
P48039 Melatonin receptor type 1A Melatonin receptor CHEMBL39 CHEMBL715947 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL39 CHEMBL1741322 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL39 CHEMBL932483 (1)
0 / 1
P06133 UDP-glucuronosyltransferase 2B4 Enzyme CHEMBL39 CHEMBL1908092 (2)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL39 CHEMBL2020014 (1) CHEMBL2020015 (1)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL39 CHEMBL617172 (1) CHEMBL617485 (1)
CHEMBL617050 (1) CHEMBL617077 (1)
CHEMBL617087 (1) CHEMBL617389 (1)
CHEMBL617256 (1) CHEMBL860341 (1)
CHEMBL854088 (1) CHEMBL854091 (1)
CHEMBL854094 (1) CHEMBL926598 (1)
CHEMBL921966 (1) CHEMBL921969 (1)
CHEMBL1012214 (1) CHEMBL979351 (1)
CHEMBL956488 (1) CHEMBL956489 (1)
CHEMBL956490 (1) CHEMBL956491 (1)
CHEMBL957590 (1) CHEMBL957591 (1)
CHEMBL2025262 (1) CHEMBL2343277 (1)
CHEMBL2343281 (1) CHEMBL2343043 (2)
CHEMBL2343044 (2) CHEMBL2343530 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL39 CHEMBL616816 (1) CHEMBL616819 (1)
CHEMBL617172 (1) CHEMBL617287 (1)
CHEMBL617294 (1) CHEMBL617512 (1)
CHEMBL617883 (1) CHEMBL620618 (1)
CHEMBL863544 (1) CHEMBL854090 (1)
CHEMBL854093 (1) CHEMBL854096 (1)
CHEMBL926599 (1) CHEMBL921965 (1)
CHEMBL921968 (1) CHEMBL1012215 (1)
CHEMBL979352 (1) CHEMBL957594 (1)
CHEMBL957595 (1) CHEMBL1041003 (1)
CHEMBL1041004 (1) CHEMBL2015999 (1)
CHEMBL2016000 (1) CHEMBL2016001 (1)
CHEMBL2016002 (1) CHEMBL2016003 (1)
CHEMBL2025268 (1) CHEMBL2343042 (2)
CHEMBL2343045 (2) CHEMBL2343529 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL39 CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL39 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2)
0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL39 CHEMBL1908080 (2)
5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL39 CHEMBL1743327 (1)
0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL39 CHEMBL615724 (1) CHEMBL615726 (1)
CHEMBL615584 (1) CHEMBL615585 (1)
CHEMBL615586 (1) CHEMBL615457 (1)
CHEMBL615461 (1) CHEMBL615463 (1)
CHEMBL615470 (1) CHEMBL615170 (1)
CHEMBL616001 (1) CHEMBL616274 (1)
CHEMBL615801 (1) CHEMBL615771 (1)
CHEMBL615778 (1) CHEMBL616301 (1)
CHEMBL616021 (1) CHEMBL616033 (1)
CHEMBL616034 (1) CHEMBL616039 (1)
CHEMBL616042 (1) CHEMBL616046 (1)
CHEMBL616228 (1) CHEMBL616245 (1)
CHEMBL616377 (1) CHEMBL875179 (1)
CHEMBL858880 (1) CHEMBL858881 (1)
CHEMBL867818 (1) CHEMBL895214 (1)
CHEMBL1035780 (1) CHEMBL953250 (1)
CHEMBL954040 (1) CHEMBL954044 (1)
CHEMBL1044820 (1) CHEMBL1065708 (1)
CHEMBL1065709 (1) CHEMBL1065710 (1)
CHEMBL1065711 (1) CHEMBL1108193 (1)
CHEMBL1108195 (1) CHEMBL2060924 (1)
CHEMBL2321534 (1) CHEMBL2342846 (2)
CHEMBL2343278 (1) CHEMBL2343282 (1)
1 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor CHEMBL39 CHEMBL616520 (1) CHEMBL616521 (1)
CHEMBL616732 (1) CHEMBL617044 (1)
CHEMBL616921 (1) CHEMBL616928 (1)
CHEMBL616933 (1) CHEMBL617588 (1)
CHEMBL617599 (1) CHEMBL617304 (1)
CHEMBL617306 (1) CHEMBL852461 (1)
CHEMBL829901 (1) CHEMBL965238 (1)
0 / 0
P30939 5-hydroxytryptamine receptor 1F Serotonin receptor CHEMBL39 CHEMBL875905 (1) CHEMBL616719 (1)
0 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL39 CHEMBL970752 (1) CHEMBL953319 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL39 CHEMBL970753 (1) CHEMBL1008327 (1)
1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL39 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL39 CHEMBL1738442 (2)
0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta CHEMBL39 CHEMBL654256 (1)
0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta CHEMBL39 CHEMBL654256 (1)
1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta CHEMBL39 CHEMBL654256 (1)
1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma CHEMBL39 CHEMBL654256 (1)
0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon CHEMBL39 CHEMBL654256 (1)
0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma CHEMBL39 CHEMBL654256 (1)
0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi CHEMBL39 CHEMBL654256 (1)
0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL39 CHEMBL654256 (1)
0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma CHEMBL39 CHEMBL654256 (1)
4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta CHEMBL39 CHEMBL654256 (1)
0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha CHEMBL39 CHEMBL654256 (1)
1 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein CHEMBL39 CHEMBL2077213 (1)
0 / 0
Q8WXA8 5-hydroxytryptamine receptor 3C NS CHEMBL39 CHEMBL858288 (1) CHEMBL618047 (1)
CHEMBL619765 (1) CHEMBL619771 (1)
CHEMBL618132 (1) CHEMBL618133 (1)
CHEMBL618134 (1) CHEMBL618135 (1)
CHEMBL618136 (1)
0 / 0
Q70Z44 5-hydroxytryptamine receptor 3D NS CHEMBL39 CHEMBL858288 (1) CHEMBL618047 (1)
CHEMBL619765 (1) CHEMBL619771 (1)
CHEMBL618132 (1) CHEMBL618133 (1)
CHEMBL618134 (1) CHEMBL618135 (1)
CHEMBL618136 (1)
0 / 0
O95264 5-hydroxytryptamine receptor 3B NS CHEMBL39 CHEMBL858288 (1) CHEMBL618047 (1)
CHEMBL619765 (1) CHEMBL619771 (1)
CHEMBL618132 (1) CHEMBL618133 (1)
CHEMBL618134 (1) CHEMBL618135 (1)
CHEMBL618136 (1)
0 / 0
A5X5Y0 5-hydroxytryptamine receptor 3E NS CHEMBL39 CHEMBL858288 (1) CHEMBL618047 (1)
CHEMBL619765 (1) CHEMBL619771 (1)
CHEMBL618132 (1) CHEMBL618133 (1)
CHEMBL618134 (1) CHEMBL618135 (1)
CHEMBL618136 (1)
0 / 0

CTD interaction (85)

compound gene gene name gene description interaction interaction type form reference
pmid
D012701 847 CAT
catalase (EC:1.11.1.6) CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin] decreases abundance
/ decreases reaction
protein 11435997
D012701 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein] increases activity
/ increases reaction
protein 15151902
D012701 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Serotonin results in increased activity of CFTR protein increases activity
protein 15151902
D012701 2597 GAPDH
G3PD
GAPD
glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D012701 2597 GAPDH
G3PD
GAPD
glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D012701 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) Serotonin results in increased phosphorylation of GSK3B protein increases phosphorylation
protein 20190034
D012701 3352 HTR1D
5-HT1D
HT1DA
HTR1DA
HTRL
RDC4
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled HTR1D gene polymorphism affects the abundance of Serotonin affects abundance
gene 17203304
D012701 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled HTR2A gene SNP results in decreased susceptibility to Serotonin decreases response to substance
gene 16314884
D012701 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled HTR2A protein affects the susceptibility to Serotonin affects response to substance
protein 16314884
D012701 3356 HTR2A
5-HT2A
HTR2
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Serotonin binds to and results in increased activity of HTR2A protein affects binding
/ increases activity
protein 16314884
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein] affects binding
/ increases activity
protein 17360702
D012701 3359 HTR3A
5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] affects binding
/ increases activity
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ decreases reaction
/ increases activity
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] affects binding
/ increases activity
/ increases reaction
protein 17360702
D012701 9177 HTR3B
5-HT3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] affects binding
/ increases activity
protein 17360702
D012701 3363 HTR7
5-HT7
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP affects binding
/ increases abundance
/ increases activity
protein 14578406
D012701 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Serotonin affects the secretion of IL12B protein affects secretion
protein 15802305
D012701 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Serotonin affects the secretion of IL1B protein affects secretion
protein 15802305
D012701 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Serotonin affects the expression of IL6 mRNA affects expression
mRNA 15802305
D012701 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Serotonin affects the secretion of IL6 protein affects secretion
protein 15802305
D012701 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Serotonin affects the expression of IL8 mRNA affects expression
mRNA 15802305
D012701 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Serotonin affects the secretion of IL8 protein affects secretion
protein 15802305
D012701 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) ITGB3 gene polymorphism affects the abundance of Serotonin affects abundance
gene 16724005
17203304
D012701 4128 MAOA
MAO-A
monoamine oxidase A (EC:1.4.3.4) MAOA gene polymorphism results in increased abundance of Serotonin increases abundance
gene 18405062
D012701 4128 MAOA
MAO-A
monoamine oxidase A (EC:1.4.3.4) MAOA protein results in increased metabolism of Serotonin increases metabolic processing
protein 10647887
D012701 4128 MAOA
MAO-A
monoamine oxidase A (EC:1.4.3.4) Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin] decreases reaction
/ increases degradation
protein 3961266
D012701 4353 MPO
myeloperoxidase (EC:1.11.2.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D012701 4353 MPO
myeloperoxidase (EC:1.11.2.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] affects binding
/ affects cotreatment
/ increases reaction
protein 23009681
D012701 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) PARP1 affects the abundance of Serotonin affects abundance
21990073
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 SLC18A1 protein results in increased uptake of Serotonin increases uptake
protein 8245983
D012701 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012701 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 Serotonin binds to SLC18A2 protein affects binding
protein 7912402
D012701 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 SLC18A2 gene SNP affects the uptake of Serotonin affects uptake
gene 15475732
D012701 85413 SLC22A16
CT2
FLIPT2
OAT6
OCT6
OKB1
dJ261K5.1
solute carrier family 22 (organic cation/carnitine transporter), member 16 Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] decreases reaction
/ increases uptake
protein 15963465
D012701 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein results in increased uptake of Serotonin increases uptake
protein 17250655
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin] increases reaction
/ increases uptake
protein 16476009
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin] increases reaction
/ increases uptake
protein 16476009
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 Serotonin binds to SLC6A4 protein affects binding
protein 16272152
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 gene polymorphism affects the abundance of Serotonin affects abundance
gene 17203304
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine decreases response to substance
/ decreases uptake
gene 20452607
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein results in increased uptake of Serotonin increases uptake
protein 16476009
20452607
D012701 6814 STXBP3
MUNC18-3
MUNC18C
PSP
UNC-18C
syntaxin binding protein 3 STXBP3 protein affects the secretion of Serotonin affects secretion
protein 18556422
D012701 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein results in increased sulfation of Serotonin increases sulfation
protein 11181495
D012701 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) SULT1A3 protein results in increased sulfation of Serotonin increases sulfation
protein 11181495
D012701 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
D012701 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Serotonin affects the secretion of TNF protein affects secretion
protein 15802305
D012701 7166 TPH1
TPRH
TRPH
TPH
tryptophan hydroxylase 1 (EC:1.14.16.4) TPH1 gene polymorphism affects the abundance of Serotonin affects abundance
gene 17203304
D012701 7166 TPH1
TPRH
TRPH
TPH
tryptophan hydroxylase 1 (EC:1.14.16.4) TPH1 gene polymorphism results in increased abundance of Serotonin increases abundance
gene 18405062
D012701 8989 TRPA1
ANKTM1
FEPS
transient receptor potential cation channel, subfamily A, member 1 TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin] affects reaction
/ increases secretion
mRNA 19507004
D012701 8989 TRPA1
ANKTM1
FEPS
transient receptor potential cation channel, subfamily A, member 1 TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin] affects reaction
/ increases secretion
mRNA 19507004
D012701 8989 TRPA1
ANKTM1
FEPS
transient receptor potential cation channel, subfamily A, member 1 TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin] affects reaction
/ increases secretion
mRNA 19507004
D012701 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin] decreases reaction
/ increases glucuronidation
protein 18214896
D012701 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) UGT1A6 gene polymorphism affects the glucuronidation of Serotonin affects glucuronidation
gene 15761113
D012701 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite affects glucuronidation
gene 15761113
D012701 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) UGT1A6 protein results in increased glucuronidation of Serotonin increases glucuronidation
protein 15761113
15761114
18214896
D012701 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) UGT1A6 protein results in increased glucuronidation of Serotonin metabolite increases glucuronidation
protein 15761113
D012701 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein affects binding
/ affects cotreatment
/ affects metabolic processing
protein 23009681
D012701 7498 XDH
XO
XOR
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] affects binding
/ affects cotreatment
/ increases reaction
protein 23009681

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
P31645
P47869
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#143500 Gilbert syndrome P22309
P22310
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#254600 Myeloperoxidase deficiency; mpod P05164
#159900 Myoclonic dystonia P14416
#164230 Obsessive-compulsive disorder; ocd P31645
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614674 Periodic fever, menstrual cycle-dependent P08908
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#190300 Tremor, hereditary essential, 1; etm1 P35462
#112100 Yt blood group antigen P22303

KEGG DISEASE (22)

KEGG disease name UniProt
H00783 Febrile seizures O14764 (related)
P18507 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00769 Hyperekplexia P23415 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00409 Type II diabetes mellitus P49286 (related)

Diseases related to CTD interactions

40 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000544 D012701 Alzheimer Disease marker/mechanism
8526997
D000648 D012701 Amnesia, Retrograde marker/mechanism
6969865
D001008 D012701 Anxiety Disorders marker/mechanism
14575894
D001022 D012701 Aortic Valve Insufficiency marker/mechanism
17636306
D001049 D012701 Apnea marker/mechanism
1013401
D001281 D012701 Atrial Fibrillation marker/mechanism
7886817
D001321 D012701 Autistic Disorder marker/mechanism
8570775
15132762
17157402
18062943
18361446
18405062
19221690
D001919 D012701 Bradycardia marker/mechanism
therapeutic
153969
155993
6105186
7672010
8112388
D002375 D012701 Catalepsy therapeutic
10193906
19429052
D002389 D012701 Catatonia marker/mechanism
6540303
D002659 D012701 Child Development Disorders, Pervasive marker/mechanism
21254450
D021081 D012701 Chronobiology Disorders marker/mechanism
17157402
D015140 D012701 Dementia, Vascular marker/mechanism
8526997
D003967 D012701 Diarrhea marker/mechanism
8112388
10446763
11488427
D004195 D012701 Disease Models, Animal marker/mechanism
11697552
D004487 D012701 Edema marker/mechanism
therapeutic
1352487
9719496
15748628
16902858
18841975
D005355 D012701 Fibrosis marker/mechanism
2523364
D005483 D012701 Flushing marker/mechanism
17636306
18784348
D006349 D012701 Heart Valve Diseases marker/mechanism
10496440
D006930 D012701 Hyperalgesia marker/mechanism
11697552
18234883
21521205
D006973 D012701 Hypertension marker/mechanism
1013401
D006976 D012701 Hypertension, Pulmonary marker/mechanism
9741569
10716603
10838744
18506000
20204739
D017379 D012701 Hypertrophy, Left Ventricular marker/mechanism
17636306
D007022 D012701 Hypotension marker/mechanism
1013401
D007249 D012701 Inflammation marker/mechanism
11697552
D043183 D012701 Irritable Bowel Syndrome marker/mechanism
11697552
D008944 D012701 Mitral Valve Insufficiency marker/mechanism
17636306
D009135 D012701 Muscular Diseases marker/mechanism
6632
986587
4809132
D009336 D012701 Necrosis marker/mechanism
6632
D009422 D012701 Nervous System Diseases marker/mechanism
9427479
9634552
9715805
D010146 D012701 Pain marker/mechanism
16730668
19109946
D011537 D012701 Pruritus marker/mechanism
18205911
D012640 D012701 Seizures marker/mechanism
therapeutic
2622091
8411779
14559291
15140183
15946324
16771832
D020230 D012701 Serotonin Syndrome marker/mechanism
11812522
D013226 D012701 Status Epilepticus marker/mechanism
15488322
15876489
D013276 D012701 Stomach Ulcer marker/mechanism
9286623
D020521 D012701 Stroke marker/mechanism
7886817
D013610 D012701 Tachycardia marker/mechanism
7886817
D059246 D012701 Tachypnea marker/mechanism
17636306
D014202 D012701 Tremor marker/mechanism
15990178