Albizia julibrissin
Species
KNApSAcK Entry
| Organism name | Albizia julibrissin |
|---|---|
| Genus | Albizia |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Albizia julibrissin |
|---|---|
| Linked NCBI taxonomy ID | 3813 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (18)
| Species | Activity |
|---|---|
| Albizia julibrissin Durazz. | Analgesic |
| Albizia julibrissin Durazz. | Antianaphylactic |
| Albizia julibrissin Durazz. | Aperitif |
| Albizia julibrissin Durazz. | Arrhythmigenic |
| Albizia julibrissin Durazz. | Calcium Blocker |
| Albizia julibrissin Durazz. | Digestive |
| Albizia julibrissin Durazz. | Discutient |
| Albizia julibrissin Durazz. | Diuretic |
| Albizia julibrissin Durazz. | Insecticide |
| Albizia julibrissin Durazz. | Memorigenic |
| Albizia julibrissin Durazz. | Proteinase Inhibitor |
| Albizia julibrissin Durazz. | Sedative |
| Albizia julibrissin Durazz. | Stimulant |
| Albizia julibrissin Durazz. | Tonic |
| Albizia julibrissin Durazz. | Tranquilizer |
| Albizia julibrissin Durazz. | Uterocontractant |
| Albizia julibrissin Durazz. | Vermifuge |
| Albizia julibrissin Durazz. | Vulnerary |
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00013935
|
Rhamnazin 3-xylosyl-(1->2)-glucoside
/ Quercetin 7,3'-dimethyl ether 3-xylosyl-(1->2)-glucoside |
No. 1 | No. 15 |
|
||||
|
C00002374
|
Chrysanthemin
/ Cyanidin 3-O-glucoside |
CHEMBL257839
CHEMBL1197952 |
C114438
|
1 / 0 / 1 | No. 2 | No. 15 |
|
|
|
C00002631
|
(+)-Lirioresinol B
/ (+)-Syringaresinol |
CHEMBL361362
CHEMBL402653 |
C042192
|
1 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00050137
|
Julibroside I
|
CHEMBL501800
|
No. 49 | No. 51 |
|
|||
|
C00050138
|
Julibroside II
|
CHEMBL504272
|
No. 49 | No. 51 |
|
|||
|
C00048996
|
Julibroside J8
|
No. 49 | No. 51 |
|
||||
|
C00050139
|
Julibroside III
|
CHEMBL452115
|
No. 49 | No. 51 |
|
|||
|
C00003825
|
3',4',7-Trihydroxyflavone
/ 7,3',4'-Trihydroxyflavone |
CHEMBL301624
|
4 / 5 / 5 | No. 71 | No. 15 |
|
||
|
C00001429
|
Serotonin
/ Enteramin / Enteramine / DS substance / Thrombotonin / Thrombocytin / 5-Hydroxytryptamine |
CHEMBL39
CHEMBL1628597 |
D012701
|
78 / 35 / 22 | 32 / 40 | No. 1910 | No. 4 |
|
|
C00001424
|
Norepinephrine
/ L-Noradrenaline / (-)-Norepinephrine |
CHEMBL432
CHEMBL18824 CHEMBL1437 CHEMBL2311152 |
D009638
|
50 / 33 / 35 | 36 / 90 | No. 3197 |
|
|
|
C00007205
|
(+)-Lyoniresinol
|
CHEMBL455365
CHEMBL1760594 CHEMBL1761710 |
No. 4145 |
|
||||
|
C00001335
|
Albizzine
/ L-Albizziine |
CHEMBL1330613
|
1 / 0 / 0 | No. 4388 |
|
|||
|
C00002679
|
Turgorin
|
No. 7099 |
|
Human Protein / Gene in interactions
126 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001424 C00001429 | 0 / 0 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001424 C00001429 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001424 C00001429 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001424 C00001429 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001424 C00001429 | 0 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001335 C00001424 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001424 C00001429 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001424 C00001429 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001424 C00001429 | 2 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001424 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001429 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001429 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001429 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001429 | 0 / 0 |
| P49286 | Melatonin receptor type 1B | Melatonin receptor | C00001429 | 0 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001424 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00002374 | 0 / 1 |
| Q99489 | D-aspartate oxidase | Enzyme | C00001424 | 0 / 0 |
| O95271 | Tankyrase-1 | Enzyme | C00003825 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001424 | 11 / 10 |
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | C00001429 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001429 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001424 | 3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001429 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 1 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | C00001429 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001429 | 0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | C00001429 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001429 | 0 / 1 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | C00001429 | 0 / 0 |
| P14920 | D-amino-acid oxidase | Enzyme | C00001424 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001424 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001424 | 1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001424 | 2 / 3 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001429 | 0 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001429 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001429 | 0 / 0 |
| P05164 | Myeloperoxidase | Enzyme | C00001429 | 1 / 2 |
| P28566 | 5-hydroxytryptamine receptor 1E | Serotonin receptor | C00001429 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001424 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001429 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001429 | 1 / 2 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001424 | 0 / 0 |
| Q7Z2W7 | Transient receptor potential cation channel subfamily M member 8 | Unclassified protein | C00001429 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00001429 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001429 | 1 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00001429 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001429 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001429 | 0 / 0 |
| P09874 | Poly [ADP-ribose] polymerase 1 | Enzyme | C00003825 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001424 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00001424 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001424 | 0 / 0 |
| P50224 | Sulfotransferase 1A3/1A4 | Enzyme | C00001424 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001424 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00001429 | 4 / 2 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001429 | 2 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001429 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00001429 | 0 / 0 |
| P48039 | Melatonin receptor type 1A | Melatonin receptor | C00001429 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001429 | 2 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001429 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001429 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001424 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001424 | 0 / 0 |
| Q9H2K2 | Tankyrase-2 | Enzyme | C00003825 | 0 / 0 |
| P06133 | UDP-glucuronosyltransferase 2B4 | Enzyme | C00001429 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001424 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001429 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001429 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001429 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001424 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001429 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001429 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001424 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001424 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00001429 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001424 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00001429 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001424 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00001429 | 1 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001424 | 1 / 1 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | C00001429 | 0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P30939 | 5-hydroxytryptamine receptor 1F | Serotonin receptor | C00001429 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001429 | 0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00003825 | 5 / 5 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001429 | 1 / 1 |
| Q13639 | 5-hydroxytryptamine receptor 4 | Serotonin receptor | C00001429 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001424 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00001429 | 1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00001429 | 3 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001424 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001424 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001424 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001424 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001424 | 1 / 4 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001429 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001429 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001429 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001429 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001429 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001429 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001429 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001429 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001429 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001429 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001429 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001429 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001429 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001429 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001429 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001429 | 1 / 0 |
| Q9Y2I1 | Nischarin | Other cytosolic protein | C00001424 | 0 / 0 |
| Q8WXA8 | 5-hydroxytryptamine receptor 3C | NS | C00001429 | 0 / 0 |
| Q70Z44 | 5-hydroxytryptamine receptor 3D | NS | C00001429 | 0 / 0 |
| O95264 | 5-hydroxytryptamine receptor 3B | NS | C00001429 | 0 / 0 |
| A5X5Y0 | 5-hydroxytryptamine receptor 3E | NS | C00001429 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001424 | 0 / 0 |
58 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6571 | SLC18A2, SVAT, SVMT, VAT2, VMAT2 | solute carrier family 18 (vesicular monoamine transporter), member 2 |
C00001424
C00001429
|
| 134864 | TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 | trace amine associated receptor 1 |
C00001424
C00001429
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00001424
C00001429
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00001424
C00001429
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00001424
C00001429
|
| 6530 | SLC6A2, NAT1, NET, NET1, SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 2 |
C00001424
C00001429
|
| 6570 | SLC18A1, CGAT, VAT1, VMAT1 | solute carrier family 18 (vesicular monoamine transporter), member 1 |
C00001424
C00001429
|
| 4128 | MAOA, MAO-A | monoamine oxidase A (EC:1.4.3.4) |
C00001424
C00001429
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001424
C00001429
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00001424
C00001429
|
| 148 | ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR | adrenoceptor alpha 1A |
C00001424
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00001424
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00001424
|
| 1813 | DRD2, D2DR, D2R | dopamine receptor D2 |
C00001424
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00001424
|
| 2778 | GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH | GNAS complex locus |
C00001424
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001424
|
| 155 | ADRB3, BETA3AR | adrenoceptor beta 3 |
C00001424
|
| 154 | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR | adrenoceptor beta 2, surface |
C00001424
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001424
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001424
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00001424
|
| 4879 | NPPB, BNP | natriuretic peptide B |
C00001424
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00001424
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001424
|
| 6279 | S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 | S100 calcium binding protein A8 |
C00001424
|
| 6280 | S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14 | S100 calcium binding protein A9 |
C00001424
|
| 6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00001424
|
| 153 | ADRB1, ADRB1R, B1AR, BETA1AR, RHR | adrenoceptor beta 1 |
C00001424
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001424
|
| 152 | ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR | adrenoceptor alpha 2C |
C00001424
|
| 151 | ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR | adrenoceptor alpha 2B |
C00001424
|
| 150 | ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 | adrenoceptor alpha 2A |
C00001424
|
| 146 | ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2 | adrenoceptor alpha 1D |
C00001424
|
| 147 | ADRA1B, ADRA1, ALPHA1BAR | adrenoceptor alpha 1B |
C00001424
|
| 7391 | USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 | upstream transcription factor 1 |
C00001424
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001429
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00001429
|
| 2597 | GAPDH, G3PD, GAPD | glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) |
C00001429
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00001429
|
| 3352 | HTR1D, 5-HT1D, HT1DA, HTR1DA, HTRL, RDC4 | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
C00001429
|
| 3356 | HTR2A, 5-HT2A, HTR2 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
C00001429
|
| 3359 | HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
C00001429
|
| 9177 | HTR3B, 5-HT3B | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic |
C00001429
|
| 3363 | HTR7, 5-HT7 | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
C00001429
|
| 3593 | IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
C00001429
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00001429
|
| 3690 | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
C00001429
|
| 4353 | MPO | myeloperoxidase (EC:1.11.2.2) |
C00001429
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001429
|
| 85413 | SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1 | solute carrier family 22 (organic cation/carnitine transporter), member 16 |
C00001429
|
| 6814 | STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C | syntaxin binding protein 3 |
C00001429
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00001429
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001429
|
| 7166 | TPH1, TPRH, TRPH, TPH | tryptophan hydroxylase 1 (EC:1.14.16.4) |
C00001429
|
| 8989 | TRPA1, ANKTM1, FEPS | transient receptor potential cation channel, subfamily A, member 1 |
C00001429
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00001429
|
| 7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00001429
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (71)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P14416
P31645 P47869 |
| #609135 | Aplastic anemia |
O14746
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #149400 | Hyperekplexia, hereditary 1; hkpx1 |
P23415
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #254600 | Myeloperoxidase deficiency; mpod |
P05164
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
|
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00101 | Other phagocyte defects |
P05164
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P05164
(marker)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00769 | Hyperekplexia |
P23415
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P28907
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00409 | Type II diabetes mellitus |
P49286
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
116 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001008 | Anxiety Disorders |
C00001424
C00001429 |
| D013610 | Tachycardia |
C00001424
C00001429 |
| D013226 | Status Epilepticus |
C00001424
C00001429 |
| D012640 | Seizures |
C00001424
C00001429 |
| D010146 | Pain |
C00001424
C00001429 |
| D009336 | Necrosis |
C00001424
C00001429 |
| D007022 | Hypotension |
C00001424
C00001429 |
| D017379 | Hypertrophy, Left Ventricular |
C00001424
C00001429 |
| D006976 | Hypertension, Pulmonary |
C00001424
C00001429 |
| D001321 | Autistic Disorder |
C00001424
C00001429 |
| D006973 | Hypertension |
C00001424
C00001429 |
| D001919 | Bradycardia |
C00001424
C00001429 |
| D006930 | Hyperalgesia |
C00001424
C00001429 |
| D002375 | Catalepsy |
C00001424
C00001429 |
| D018754 | Ventricular Dysfunction |
C00001424
|
| D002303 | Cardiac Output, Low |
C00001424
|
| D006332 | Cardiomegaly |
C00001424
|
| D009202 | Cardiomyopathies |
C00001424
|
| D002037 | Bundle-Branch Block |
C00001424
|
| D002543 | Cerebral Hemorrhage |
C00001424
|
| D019970 | Cocaine-Related Disorders |
C00001424
|
| D003922 | Diabetes Mellitus, Type 1 |
C00001424
|
| D004409 | Dyskinesia, Drug-Induced |
C00001424
|
| D004421 | Dystonia |
C00001424
|
| D004827 | Epilepsy |
C00001424
|
| D005901 | Glaucoma |
C00001424
|
| D005921 | Glomerulonephritis |
C00001424
|
| D005923 | Glomerulosclerosis, Focal Segmental |
C00001424
|
| D006261 | Headache |
C00001424
|
| D006323 | Heart Arrest |
C00001424
|
| D006331 | Heart Diseases |
C00001424
|
| D006333 | Heart Failure |
C00001424
|
| D006470 | Hemorrhage |
C00001424
|
| D002545 | Brain Ischemia |
C00001424
|
| D006935 | Hypercapnia |
C00001424
|
| D006940 | Hyperemia |
C00001424
|
| D001766 | Blindness |
C00001424
|
| D006974 | Hypertension, Malignant |
C00001424
|
| D001237 | Asphyxia |
C00001424
|
| D006984 | Hypertrophy |
C00001424
|
| D001145 | Arrhythmias, Cardiac |
C00001424
|
| D007008 | Hypokalemia |
C00001424
|
| D058186 | Acute Kidney Injury |
C00001424
|
| D007024 | Hypotension, Orthostatic |
C00001424
|
| D007035 | Hypothermia |
C00001424
|
| D007511 | Ischemia |
C00001424
|
| D007674 | Kidney Diseases |
C00001424
|
| D008113 | Liver Neoplasms |
C00001424
|
| D008114 | Liver Neoplasms, Experimental |
C00001424
|
| D009203 | Myocardial Infarction |
C00001424
|
| D017202 | Myocardial Ischemia |
C00001424
|
| D015428 | Myocardial Reperfusion Injury |
C00001424
|
| D001002 | Anuria |
C00001424
|
| D009410 | Nerve Degeneration |
C00001424
|
| D009798 | Ocular Hypertension |
C00001424
|
| D009846 | Oliguria |
C00001424
|
| D009901 | Optic Nerve Diseases |
C00001424
|
| D000860 | Anoxia |
C00001424
|
| D010243 | Paralysis |
C00001424
|
| D010554 | Personality Disorders |
C00001424
|
| D011183 | Postoperative Complications |
C00001424
|
| D011249 | Pregnancy Complications, Cardiovascular |
C00001424
|
| D011297 | Prenatal Exposure Delayed Effects |
C00001424
|
| D011507 | Proteinuria |
C00001424
|
| D011605 | Psychoses, Substance-Induced |
C00001424
|
| D029424 | Pulmonary Disease, Chronic Obstructive |
C00001424
|
| D051437 | Renal Insufficiency |
C00001424
|
| D012120 | Respiration Disorders |
C00001424
|
| D012131 | Respiratory Insufficiency |
C00001424
|
| D012164 | Retinal Diseases |
C00001424
|
| D012206 | Rhabdomyolysis |
C00001424
|
| D017542 | Aneurysm, Ruptured |
C00001424
|
| D018805 | Sepsis |
C00001424
|
| D012769 | Shock |
C00001424
|
| D012770 | Shock, Cardiogenic |
C00001424
|
| D012771 | Shock, Hemorrhagic |
C00001424
|
| D012772 | Shock, Septic |
C00001424
|
| D013035 | Spasm |
C00001424
|
| D019969 | Amphetamine-Related Disorders |
C00001424
|
| D013274 | Stomach Neoplasms |
C00001424
|
| D013345 | Subarachnoid Hemorrhage |
C00001424
|
| D013375 | Substance Withdrawal Syndrome |
C00001424
|
| D000647 | Amnesia |
C00001424
|
| D013616 | Tachycardia, Sinus |
C00001424
|
| D017180 | Tachycardia, Ventricular |
C00001424
|
| D014511 | Uremia |
C00001424
|
| D056987 | Vasoplegia |
C00001424
|
| D002100 | Cachexia |
C00001424
|
| D018487 | Ventricular Dysfunction, Left |
C00001424
|
| D014693 | Ventricular Fibrillation |
C00001424
|
| D000544 | Alzheimer Disease |
C00001429
|
| D000648 | Amnesia, Retrograde |
C00001429
|
| D001022 | Aortic Valve Insufficiency |
C00001429
|
| D001049 | Apnea |
C00001429
|
| D001281 | Atrial Fibrillation |
C00001429
|
| D002389 | Catatonia |
C00001429
|
| D002659 | Child Development Disorders, Pervasive |
C00001429
|
| D021081 | Chronobiology Disorders |
C00001429
|
| D015140 | Dementia, Vascular |
C00001429
|
| D003967 | Diarrhea |
C00001429
|
| D004195 | Disease Models, Animal |
C00001429
|
| D004487 | Edema |
C00001429
|
| D005355 | Fibrosis |
C00001429
|
| D005483 | Flushing |
C00001429
|
| D006349 | Heart Valve Diseases |
C00001429
|
| D007249 | Inflammation |
C00001429
|
| D043183 | Irritable Bowel Syndrome |
C00001429
|
| D008944 | Mitral Valve Insufficiency |
C00001429
|
| D009135 | Muscular Diseases |
C00001429
|
| D009422 | Nervous System Diseases |
C00001429
|
| D011537 | Pruritus |
C00001429
|
| D020230 | Serotonin Syndrome |
C00001429
|
| D013276 | Stomach Ulcer |
C00001429
|
| D020521 | Stroke |
C00001429
|
| D059246 | Tachypnea |
C00001429
|
| D014202 | Tremor |
C00001429
|