| id | C00002638 | 
|---|---|
| Name | Arbutin | 
| CAS RN | 497-76-7 | 
| Standard InChI | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8?,9-,10+,11?,12-/m1/s1 | 
| Standard InChI (Main Layer) | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2 | 
| Phytochemical cluster | No. 72 | 
|---|---|
| KCF-S cluster | No. 45 | 
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL226495 CHEMBL232202 CHEMBL1357990 | 
| By LinkDB | C06186 | 
|---|
| By CAS RN | D001104 | 
|---|
| class name | count | 
|---|---|
| asterids | 5 | 
| rosids | 4 | 
| eudicotyledons | 2 | 
| family name | count | 
|---|---|
| Ericaceae | 2 | 
| Rosaceae | 2 | 
| Saxifragaceae | 1 | 
| Plantaginaceae | 1 | 
| Fabaceae | 1 | 
| Crassulaceae | 1 | 
| Phyllanthaceae | 1 | 
| Enterobacteriaceae | 1 | 
| Lamiaceae | 1 | 
| Apiaceae | 1 | 
| accession | description | class description | compound | assay ID (# of activities) | 
                        # of diseases
                         (OMIM / KEGG)  | 
                    
|---|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL232202 | 
                        CHEMBL1014033
                        (1)
                         | 
                      0 / 3 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL232202 | 
                        CHEMBL1794584
                        (1)
                         | 
                      2 / 0 | 
| P14679 | Tyrosinase | Oxidoreductase | CHEMBL232202 | 
                        CHEMBL814342
                        (1)
                        CHEMBL940816
                        (1)
                         CHEMBL980232 (1) CHEMBL1013463 (1)  | 
                      4 / 2 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL232202 | 
                        CHEMBL2354311
                        (1)
                         | 
                      1 / 0 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL1357990 | 
                        CHEMBL2114738
                        (1)
                         | 
                      0 / 0 | 
| compound | gene | gene name | gene description | interaction | interaction type | form | 
                        reference
                         pmid  | 
                    
|---|---|---|---|---|---|---|---|
| D001104 | 10349 | 
                        ABCA10
                         EST698739  | 
                      ATP-binding cassette, sub-family A (ABC1), member 10 | Arbutin results in decreased expression of ABCA10 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 154664 | 
                        ABCA13
                         | 
                      ATP-binding cassette, sub-family A (ABC1), member 13 | Arbutin results in decreased expression of ABCA13 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 150000 | 
                        ABCC13
                         C21orf73 PRED6  | 
                      ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene | Arbutin results in decreased expression of ABCC13 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 130013 | 
                        ACMSD
                         | 
                      aminocarboxymuconate semialdehyde decarboxylase (EC:4.1.1.45) | Arbutin results in decreased expression of ACMSD mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 94 | 
                        ACVRL1
                         ACVRLK1 ALK-1 ALK1 HHT HHT2 ORW2 SKR3 TSR-I  | 
                      activin A receptor type II-like 1 (EC:2.7.11.30) | Arbutin results in decreased expression of ACVRL1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8728 | 
                        ADAM19
                         MADDAM MLTNB  | 
                      ADAM metallopeptidase domain 19 | Arbutin results in decreased expression of ADAM19 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8748 | 
                        ADAM20
                         | 
                      ADAM metallopeptidase domain 20 | Arbutin results in decreased expression of ADAM20 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8756 | 
                        ADAM7
                         ADAM_7 ADAM-7 EAPI GP-83 GP83  | 
                      ADAM metallopeptidase domain 7 | Arbutin results in increased expression of ADAM7 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9508 | 
                        ADAMTS3
                         ADAMTS-4  | 
                      ADAM metallopeptidase with thrombospondin type 1 motif, 3 (EC:3.4.24.-) | Arbutin results in decreased expression of ADAMTS3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 56999 | 
                        ADAMTS9
                         | 
                      ADAM metallopeptidase with thrombospondin type 1 motif, 9 | Arbutin results in decreased expression of ADAMTS9 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 155 | 
                        ADRB3
                         BETA3AR  | 
                      adrenoceptor beta 3 | Arbutin results in decreased expression of ADRB3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 121536 | 
                        AEBP2
                         | 
                      AE binding protein 2 | Arbutin results in increased expression of AEBP2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 60312 | 
                        AFAP1
                         AFAP AFAP-110 AFAP110  | 
                      actin filament associated protein 1 | Arbutin results in decreased expression of AFAP1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84871 | 
                        AGBL4
                         CCP6  | 
                      ATP/GTP binding protein-like 4 | Arbutin results in decreased expression of AGBL4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 56894 | 
                        AGPAT3
                         LPAAT-GAMMA1 LPAAT3  | 
                      1-acylglycerol-3-phosphate O-acyltransferase 3 (EC:2.3.1.51) | Arbutin results in decreased expression of AGPAT3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79026 | 
                        AHNAK
                         AHNAKRS  | 
                      AHNAK nucleoprotein | Arbutin results in decreased expression of AHNAK mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 207 | 
                        AKT1
                         AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA  | 
                      v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Arbutin results in decreased expression of AKT1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 401138 | 
                        AMTN
                         UNQ689  | 
                      amelotin | Arbutin results in decreased expression of AMTN mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 26057 | 
                        ANKRD17
                         GTAR NY-BR-16  | 
                      ankyrin repeat domain 17 | Arbutin results in increased expression of ANKRD17 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 200539 | 
                        ANKRD23
                         DARP MARP3  | 
                      ankyrin repeat domain 23 | Arbutin results in increased expression of ANKRD23 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1174 | 
                        AP1S1
                         AP19 CLAPS1 MEDNIK SIGMA1A WUGSC:H_DJ0747G18.2  | 
                      adaptor-related protein complex 1, sigma 1 subunit | Arbutin results in decreased expression of AP1S1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55937 | 
                        APOM
                         G3a HSPC336 NG20 apo-M  | 
                      apolipoprotein M | Arbutin results in increased expression of APOM mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 54840 | 
                        APTX
                         AOA AOA1 AXA1 EAOH EOAHA FHA-HIT  | 
                      aprataxin | Arbutin results in decreased expression of APTX mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23647 | 
                        ARFIP2
                         POR1  | 
                      ADP-ribosylation factor interacting protein 2 | Arbutin results in decreased expression of ARFIP2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9181 | 
                        ARHGEF2
                         GEF GEF-H1 GEFH1 LFP40 P40  | 
                      Rho/Rac guanine nucleotide exchange factor (GEF) 2 | Arbutin results in decreased expression of ARHGEF2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 402 | 
                        ARL2
                         ARFL2  | 
                      ADP-ribosylation factor-like 2 | Arbutin results in decreased expression of ARL2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23204 | 
                        ARL6IP1
                         AIP1 ARL6IP ARMER  | 
                      ADP-ribosylation factor-like 6 interacting protein 1 | Arbutin results in increased expression of ARL6IP1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 170302 | 
                        ARX
                         CT121 EIEE1 ISSX MRX29 MRX32 MRX33 MRX36 MRX38 MRX43 MRX54 MRX76 MRX87 MRXS1 PRTS  | 
                      aristaless related homeobox | Arbutin results in decreased expression of ARX mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55616 | 
                        ASAP3
                         ACAP4 CENTB6 DDEFL1 UPLC1  | 
                      ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | Arbutin results in decreased expression of ASAP3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 439 | 
                        ASNA1
                         ARSA-I ARSA1 ASNA-I GET3 TRC40 hASNA-I  | 
                      arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) (EC:3.6.3.16) | Arbutin results in decreased expression of ASNA1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 83858 | 
                        ATAD3B
                         AAA-TOB3 TOB3  | 
                      ATPase family, AAA domain containing 3B | Arbutin results in decreased expression of ATAD3B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1388 | 
                        ATF6B
                         CREB-RP CREBL1 G13  | 
                      activating transcription factor 6 beta | Arbutin results in decreased expression of ATF6B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 338707 | 
                        B4GALNT4
                         | 
                      beta-1,4-N-acetyl-galactosaminyl transferase 4 (EC:2.4.1.244) | Arbutin results in decreased expression of B4GALNT4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9529 | 
                        BAG5
                         BAG-5  | 
                      BCL2-associated athanogene 5 | Arbutin results in decreased expression of BAG5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10286 | 
                        BCAS2
                         DAM1 SPF27 Snt309  | 
                      breast carcinoma amplified sequence 2 | Arbutin results in increased expression of BCAS2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10295 | 
                        BCKDK
                         BCKDKD BDK  | 
                      branched chain ketoacid dehydrogenase kinase (EC:2.7.11.4) | Arbutin results in decreased expression of BCKDK mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 658 | 
                        BMPR1B
                         ALK-6 ALK6 CDw293  | 
                      bone morphogenetic protein receptor, type IB (EC:2.7.11.30) | Arbutin results in decreased expression of BMPR1B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 663 | 
                        BNIP2
                         BNIP-2 NIP2  | 
                      BCL2/adenovirus E1B 19kDa interacting protein 2 | Arbutin results in increased expression of BNIP2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84446 | 
                        BRSK1
                         hSAD1  | 
                      BR serine/threonine kinase 1 (EC:2.7.11.1 2.7.11.26) | Arbutin results in decreased expression of BRSK1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 684 | 
                        BST2
                         CD317 TETHERIN  | 
                      bone marrow stromal cell antigen 2 | Arbutin results in decreased expression of BST2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 11120 | 
                        BTN2A1
                         BK14H9.1 BT2.1 BTF1 DJ3E1.1  | 
                      butyrophilin, subfamily 2, member A1 | Arbutin results in decreased expression of BTN2A1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9256 | 
                        BZRAP1
                         PBR-IP PRAX-1 PRAX1 RIM-BP1 RIMBP1  | 
                      benzodiazapine receptor (peripheral) associated protein 1 | Arbutin results in decreased expression of BZRAP1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 161502 | 
                        C15orf26
                         | 
                      chromosome 15 open reading frame 26 | Arbutin results in decreased expression of C15ORF26 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84529 | 
                        C15orf41
                         HH114  | 
                      chromosome 15 open reading frame 41 | Arbutin results in increased expression of C15ORF41 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 64073 | 
                        C19orf33
                         H2RSP IMUP IMUP-1 IMUP-2  | 
                      chromosome 19 open reading frame 33 | Arbutin results in decreased expression of C19ORF33 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84808 | 
                        C1orf170
                         RP11-54O7.8  | 
                      chromosome 1 open reading frame 170 | Arbutin results in decreased expression of C1ORF170 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10485 | 
                        C1orf61
                         CROC4  | 
                      chromosome 1 open reading frame 61 | Arbutin results in decreased expression of C1ORF61 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 127795 | 
                        C1orf87
                         | 
                      chromosome 1 open reading frame 87 | Arbutin results in decreased expression of C1ORF87 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 713 | 
                        C1QB
                         | 
                      complement component 1, q subcomponent, B chain | Arbutin results in decreased expression of C1QB mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 59284 | 
                        CACNG7
                         | 
                      calcium channel, voltage-dependent, gamma subunit 7 | Arbutin results in decreased expression of CACNG7 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84290 | 
                        CAPNS2
                         | 
                      calpain, small subunit 2 | Arbutin results in increased expression of CAPNS2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 841 | 
                        CASP8
                         ALPS2B CAP4 Casp-8 FLICE MACH MCH5  | 
                      caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Arbutin results in decreased expression of CASP8 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23466 | 
                        CBX6
                         | 
                      chromobox homolog 6 | Arbutin results in decreased expression of CBX6 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55749 | 
                        CCAR1
                         RP11-437A18.1  | 
                      cell division cycle and apoptosis regulator 1 | Arbutin results in increased expression of CCAR1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80129 | 
                        CCDC170
                         C6orf97 bA282P11.1  | 
                      coiled-coil domain containing 170 | Arbutin results in decreased expression of CCDC170 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79140 | 
                        CCDC28B
                         RP4-622L5.5  | 
                      coiled-coil domain containing 28B | Arbutin results in decreased expression of CCDC28B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 151195 | 
                        CCNYL1
                         | 
                      cyclin Y-like 1 | Arbutin results in increased expression of CCNYL1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10694 | 
                        CCT8
                         C21orf112 Cctq D21S246 PRED71  | 
                      chaperonin containing TCP1, subunit 8 (theta) | Arbutin results in increased expression of CCT8 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 977 | 
                        CD151
                         GP27 MER2 PETA-3 RAPH SFA1 TSPAN24  | 
                      CD151 molecule (Raph blood group) | Arbutin results in decreased expression of CD151 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 11126 | 
                        CD160
                         BY55 NK1 NK28  | 
                      CD160 molecule | Arbutin results in decreased expression of CD160 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 283316 | 
                        CD163L1
                         CD163B M160  | 
                      CD163 molecule-like 1 | Arbutin results in decreased expression of CD163L1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10421 | 
                        CD2BP2
                         FWP010 LIN1 PPP1R59 Snu40 U5-52K  | 
                      CD2 (cytoplasmic tail) binding protein 2 | Arbutin results in decreased expression of CD2BP2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 917 | 
                        CD3G
                         CD3-GAMMA T3G  | 
                      CD3g molecule, gamma (CD3-TCR complex) | Arbutin results in decreased expression of CD3G mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5127 | 
                        CDK16
                         PCTAIRE PCTAIRE1 PCTGAIRE PCTK1  | 
                      cyclin-dependent kinase 16 (EC:2.7.11.22) | Arbutin results in decreased expression of CDK16 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 634 | 
                        CEACAM1
                         BGP BGP1 BGPI  | 
                      carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Arbutin results in decreased expression of CEACAM1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 170482 | 
                        CLEC4C
                         BDCA2 CD303 CLECSF11 CLECSF7 DLEC HECL PRO34150  | 
                      C-type lectin domain family 4, member C | Arbutin results in decreased expression of CLEC4C mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 22866 | 
                        CNKSR2
                         CNK2 KSR2 MAGUIN  | 
                      connector enhancer of kinase suppressor of Ras 2 | Arbutin results in decreased expression of CNKSR2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1308 | 
                        COL17A1
                         BA16H23.2 BP180 BPA-2 BPAG2 LAD-1  | 
                      collagen, type XVII, alpha 1 | Arbutin results in decreased expression of COL17A1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1360 | 
                        CPB1
                         CPB PASP PCPB  | 
                      carboxypeptidase B1 (tissue) (EC:3.4.17.2) | Arbutin results in decreased expression of CPB1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1363 | 
                        CPE
                         | 
                      carboxypeptidase E (EC:3.4.17.10) | Arbutin results in increased expression of CPE mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 57699 | 
                        CPNE5
                         COPN5 CPN5  | 
                      copine V | Arbutin results in increased expression of CPNE5 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 113612 | 
                        CYP2U1
                         P450TEC SPG49 SPG56  | 
                      cytochrome P450, family 2, subfamily U, polypeptide 1 (EC:1.14.14.1) | Arbutin results in increased expression of CYP2U1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 326709 | Arbutin results in increased expression of DDEF1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    ||
| D001104 | 9879 | 
                        DDX46
                         PRPF5 Prp5  | 
                      DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 (EC:3.6.4.13) | Arbutin results in increased expression of DDX46 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1730 | 
                        DIAPH2
                         DIA DIA2 DRF2 POF POF2  | 
                      diaphanous-related formin 2 | Arbutin results in decreased expression of DIAPH2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 22839 | 
                        DLGAP4
                         DAP4 DLP4 RP5-977B1.6 SAPAP4  | 
                      discs, large (Drosophila) homolog-associated protein 4 | Arbutin results in increased expression of DLGAP4 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1745 | 
                        DLX1
                         | 
                      distal-less homeobox 1 | Arbutin results in decreased expression of DLX1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1657 | 
                        DMXL1
                         | 
                      Dmx-like 1 | Arbutin results in decreased expression of DMXL1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 56171 | 
                        DNAH7
                         | 
                      dynein, axonemal, heavy chain 7 | Arbutin results in decreased expression of DNAH7 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4189 | 
                        DNAJB9
                         ERdj4 MDG-1 MDG1 MST049 MSTP049  | 
                      DnaJ (Hsp40) homolog, subfamily B, member 9 | Arbutin results in increased expression of DNAJB9 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 29952 | 
                        DPP7
                         DPP2 DPPII QPP  | 
                      dipeptidyl-peptidase 7 (EC:3.4.14.2) | Arbutin results in decreased expression of DPP7 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1808 | 
                        DPYSL2
                         CRMP-2 CRMP2 DHPRP2 DRP-2 DRP2 N2A3 ULIP-2 ULIP2  | 
                      dihydropyrimidinase-like 2 | Arbutin results in decreased expression of DPYSL2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1889 | 
                        ECE1
                         ECE  | 
                      endothelin converting enzyme 1 (EC:3.4.24.71) | Arbutin results in increased expression of ECE1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80820 | 
                        EEPD1
                         HSPC107  | 
                      endonuclease/exonuclease/phosphatase family domain containing 1 | Arbutin results in increased expression of EEPD1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80258 | 
                        EFHC2
                         dJ1158H2.1  | 
                      EF-hand domain (C-terminal) containing 2 | Arbutin results in decreased expression of EFHC2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1944 | 
                        EFNA3
                         EFL2 EPLG3 Ehk1-L LERK3  | 
                      ephrin-A3 | Arbutin results in decreased expression of EFNA3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10278 | 
                        EFS
                         CAS3 CASS3 EFS1 EFS2 HEFS SIN  | 
                      embryonal Fyn-associated substrate | Arbutin results in decreased expression of EFS mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79631 | 
                        EFTUD1
                         FAM42A HsT19294 RIA1  | 
                      elongation factor Tu GTP binding domain containing 1 | Arbutin results in increased expression of EFTUD1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23741 | 
                        EID1
                         C15orf3 CRI1 EID-1 IRO45620 PTD014 RBP21  | 
                      EP300 interacting inhibitor of differentiation 1 | Arbutin results in increased expression of EID1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 1991 | 
                        ELANE
                         ELA2 GE HLE HNE NE PMN-E SCN1  | 
                      elastase, neutrophil expressed (EC:3.4.21.37) | Arbutin results in decreased expression of ELANE mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2018 | 
                        EMX2
                         | 
                      empty spiracles homeobox 2 | Arbutin results in decreased expression of EMX2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5167 | 
                        ENPP1
                         ARHR2 M6S1 NPP1 NPPS PC-1 PCA1 PDNP1  | 
                      ectonucleotide pyrophosphatase/phosphodiesterase 1 (EC:3.1.4.1 3.6.1.9) | Arbutin results in decreased expression of ENPP1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2059 | 
                        EPS8
                         | 
                      epidermal growth factor receptor pathway substrate 8 | Arbutin results in increased expression of EPS8 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8288 | 
                        EPX
                         EPO EPP EPX-PEN  | 
                      eosinophil peroxidase (EC:1.11.1.7) | Arbutin results in increased expression of EPX mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23085 | 
                        ERC1
                         Cast2 ELKS RAB6IP2  | 
                      ELKS/RAB6-interacting/CAST family member 1 | Arbutin results in increased expression of ERC1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 711 | 
                        ERC2-IT1
                         C1orf1 C3orf51 Po42  | 
                      ERC2 intronic transcript 1 (non-protein coding) | Arbutin results in decreased expression of ERC2-IT1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2124 | 
                        EVI2B
                         CD361 D17S376 EVDB  | 
                      ecotropic viral integration site 2B | Arbutin results in decreased expression of EVI2B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 161829 | 
                        EXD1
                         EXDL1  | 
                      exonuclease 3'-5' domain containing 1 | Arbutin results in decreased expression of EXD1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2165 | 
                        F13B
                         FXIIIB  | 
                      coagulation factor XIII, B polypeptide (EC:2.3.2.13) | Arbutin results in decreased expression of F13B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 131177 | 
                        FAM3D
                         EF7 OIT1  | 
                      family with sequence similarity 3, member D | Arbutin results in decreased expression of FAM3D mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51571 | 
                        FAM49B
                         L1  | 
                      family with sequence similarity 49, member B | Arbutin results in increased expression of FAM49B mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 115795 | 
                        FANCD2OS
                         C3orf24  | 
                      FANCD2 opposite strand | Arbutin results in decreased expression of FANCD2OS mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 356 | 
                        FASLG
                         ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6  | 
                      Fas ligand (TNF superfamily, member 6) | Arbutin results in decreased expression of FASLG mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80204 | 
                        FBXO11
                         FBX11 PRMT9 UBR6 VIT1  | 
                      F-box protein 11 | Arbutin results in increased expression of FBXO11 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 157574 | 
                        FBXO16
                         FBX16  | 
                      F-box protein 16 | Arbutin results in increased expression of FBXO16 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2250 | 
                        FGF5
                         HBGF-5 Smag-82  | 
                      fibroblast growth factor 5 | Arbutin results in decreased expression of FGF5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2261 | 
                        FGFR3
                         ACH CD333 CEK2 HSFGFR3EX JTK4  | 
                      fibroblast growth factor receptor 3 (EC:2.7.10.1) | Arbutin results in decreased expression of FGFR3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 91010 | 
                        FMNL3
                         FHOD3 WBP-3 WBP3  | 
                      formin-like 3 | Arbutin results in decreased expression of FMNL3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8790 | 
                        FPGT
                         GFPP  | 
                      fucose-1-phosphate guanylyltransferase (EC:2.7.7.30) | Arbutin results in decreased expression of FPGT mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80144 | 
                        FRAS1
                         | 
                      Fraser syndrome 1 | Arbutin results in decreased expression of FRAS1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9758 | 
                        FRMPD4
                         PDZD10 PDZK10  | 
                      FERM and PDZ domain containing 4 | Arbutin results in decreased expression of FRMPD4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2581 | 
                        GALC
                         | 
                      galactosylceramidase (EC:3.2.1.46) | Arbutin results in increased expression of GALC mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 64762 | 
                        GAREM
                         C18orf11 FAM59A Gm944  | 
                      GRB2 associated, regulator of MAPK1 | Arbutin results in increased expression of GAREM mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10755 | 
                        GIPC1
                         C19orf3 GIPC GLUT1CBP Hs.6454 IIP-1 NIP RGS19IP1 SEMCAP SYNECTIIN SYNECTIN TIP-2  | 
                      GIPC PDZ domain containing family, member 1 | Arbutin results in decreased expression of GIPC1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 83468 | 
                        GLT8D2
                         | 
                      glycosyltransferase 8 domain containing 2 | Arbutin results in decreased expression of GLT8D2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2766 | 
                        GMPR
                         GMPR1  | 
                      guanosine monophosphate reductase (EC:1.7.1.7) | Arbutin results in decreased expression of GMPR mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 29889 | 
                        GNL2
                         HUMAUANTIG NGP1 Ngp-1  | 
                      guanine nucleotide binding protein-like 2 (nucleolar) | Arbutin results in increased expression of GNL2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2719 | 
                        GPC3
                         DGSX GTR2-2 MXR7 OCI-5 SDYS SGB SGBS SGBS1  | 
                      glypican 3 | Arbutin results in decreased expression of GPC3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2820 | 
                        GPD2
                         GDH2 GPDM mGPDH  | 
                      glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (EC:1.1.5.3) | Arbutin results in increased expression of GPD2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 151556 | 
                        GPR155
                         DEP.7 DEPDC3 PGR22  | 
                      G protein-coupled receptor 155 | Arbutin results in decreased expression of GPR155 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2849 | 
                        GPR26
                         | 
                      G protein-coupled receptor 26 | Arbutin results in decreased expression of GPR26 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2854 | 
                        GPR32
                         RVDR1  | 
                      G protein-coupled receptor 32 | Arbutin results in increased expression of GPR32 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9290 | 
                        GPR55
                         | 
                      G protein-coupled receptor 55 | Arbutin results in decreased expression of GPR55 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55507 | 
                        GPRC5D
                         | 
                      G protein-coupled receptor, family C, group 5, member D | Arbutin results in decreased expression of GPRC5D mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 284110 | 
                        GSDMA
                         GSDM GSDM1  | 
                      gasdermin A | Arbutin results in decreased expression of GSDMA mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 2977 | 
                        GUCY1A2
                         GC-SA2 GUC1A2  | 
                      guanylate cyclase 1, soluble, alpha 2 (EC:4.6.1.2) | Arbutin results in decreased expression of GUCY1A2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9421 | 
                        HAND1
                         Hxt Thing1 bHLHa27 eHand  | 
                      heart and neural crest derivatives expressed 1 | Arbutin results in increased expression of HAND1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3024 | 
                        HIST1H1A
                         H1.1 H1A H1F1 HIST1  | 
                      histone cluster 1, H1a | Arbutin results in increased expression of HIST1H1A mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8334 | 
                        HIST1H2AC
                         H2A/l H2AFL dJ221C16.4  | 
                      histone cluster 1, H2ac | Arbutin results in increased expression of HIST1H2AC mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3131 | 
                        HLF
                         | 
                      hepatic leukemia factor | Arbutin results in decreased expression of HLF mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3218 | 
                        HOXB8
                         HOX2 HOX2D Hox-2.4  | 
                      homeobox B8 | Arbutin results in decreased expression of HOXB8 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84343 | 
                        HPS3
                         SUTAL  | 
                      Hermansky-Pudlak syndrome 3 | Arbutin results in decreased expression of HPS3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3283 | 
                        HSD3B1
                         3BETAHSD HSD3B HSDB3 HSDB3A I SDR11E1  | 
                      hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (EC:1.1.1.145 5.3.3.1) | Arbutin results in decreased expression of HSD3B1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 27336 | 
                        HTATSF1
                         TAT-SF1 TATSF1 dJ196E23.2  | 
                      HIV-1 Tat specific factor 1 | Arbutin results in increased expression of HTATSF1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3437 | 
                        IFIT3
                         CIG-49 GARG-49 IFI60 IFIT4 IRG2 ISG60 P60 RIG-G  | 
                      interferon-induced protein with tetratricopeptide repeats 3 | Arbutin results in decreased expression of IFIT3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9543 | 
                        IGDCC3
                         HsT18880 PUNC  | 
                      immunoglobulin superfamily, DCC subclass, member 3 | Arbutin results in decreased expression of IGDCC3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51561 | 
                        IL23A
                         IL-23 IL-23A IL23P19 P19 SGRF  | 
                      interleukin 23, alpha subunit p19 | Arbutin results in decreased expression of IL23A mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3563 | 
                        IL3RA
                         CD123 IL3R IL3RAY IL3RX IL3RY hIL-3Ra  | 
                      interleukin 3 receptor, alpha (low affinity) | Arbutin results in increased expression of IL3RA mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3572 | 
                        IL6ST
                         CD130 CDW130 GP130 IL-6RB  | 
                      interleukin 6 signal transducer (gp130, oncostatin M receptor) | Arbutin results in decreased expression of IL6ST mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9118 | 
                        INA
                         NEF5 NF-66 TXBP-1  | 
                      internexin neuronal intermediate filament protein, alpha | Arbutin results in decreased expression of INA mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8821 | 
                        INPP4B
                         | 
                      inositol polyphosphate-4-phosphatase, type II, 105kDa (EC:3.1.3.66) | Arbutin results in increased expression of INPP4B mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3725 | 
                        JUN
                         AP-1 AP1 c-Jun  | 
                      jun proto-oncogene | Arbutin results in decreased expression of JUN mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9196 | 
                        KCNAB3
                         AKR6A9 KCNA3.1B KCNA3B KV-BETA-3  | 
                      potassium voltage-gated channel, shaker-related subfamily, beta member 3 | Arbutin results in decreased expression of KCNAB3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79734 | 
                        KCTD17
                         | 
                      potassium channel tetramerization domain containing 17 | Arbutin results in decreased expression of KCTD17 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79070 | 
                        KDELC1
                         EP58 KDEL1  | 
                      KDEL (Lys-Asp-Glu-Leu) containing 1 | Arbutin results in increased expression of KDELC1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55083 | 
                        KIF26B
                         | 
                      kinesin family member 26B | Arbutin results in decreased expression of KIF26B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 90293 | 
                        KLHL13
                         BKLHD2 KIAA1309  | 
                      kelch-like family member 13 | Arbutin results in increased expression of KLHL13 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8302 | 
                        KLRC4
                         NKG2-F NKG2F  | 
                      killer cell lectin-like receptor subfamily C, member 4 | Arbutin results in increased expression of KLRC4 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 197021 | 
                        LCTL
                         KLG KLPH  | 
                      lactase-like | Arbutin results in decreased expression of LCTL mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 56891 | 
                        LGALS14
                         CLC2 PPL13  | 
                      lectin, galactoside-binding, soluble, 14 | Arbutin results in decreased expression of LGALS14 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79166 | 
                        LILRP2
                         CD85m ILT10 LILRA5  | 
                      leukocyte immunoglobulin-like receptor pseudogene 2 | Arbutin results in decreased expression of LILRP2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4041 | 
                        LRP5
                         BMND1 EVR1 EVR4 HBM LR3 LRP7 OPPG OPS OPTA1 VBCH2  | 
                      low density lipoprotein receptor-related protein 5 | Arbutin results in decreased expression of LRP5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4040 | 
                        LRP6
                         ADCAD2  | 
                      low density lipoprotein receptor-related protein 6 | Arbutin results in decreased expression of LRP6 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 64101 | 
                        LRRC4
                         NGL-2  | 
                      leucine rich repeat containing 4 | Arbutin results in decreased expression of LRRC4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80059 | 
                        LRRTM4
                         | 
                      leucine rich repeat transmembrane neuronal 4 | Arbutin results in decreased expression of LRRTM4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7975 | 
                        MAFK
                         NFE2U P18  | 
                      v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | Arbutin results in decreased expression of MAFK mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 11183 | 
                        MAP4K5
                         GCKR KHS KHS1 MAPKKKK5  | 
                      mitogen-activated protein kinase kinase kinase kinase 5 (EC:2.7.11.1) | Arbutin results in decreased expression of MAP4K5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5599 | 
                        MAPK8
                         JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c  | 
                      mitogen-activated protein kinase 8 (EC:2.7.11.24) | Arbutin results in decreased expression of MAPK8 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84515 | 
                        MCM8
                         C20orf154 dJ967N21.5  | 
                      minichromosome maintenance complex component 8 (EC:3.6.4.12) | Arbutin results in increased expression of MCM8 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4188 | 
                        MDFI
                         I-MF I-mfa  | 
                      MyoD family inhibitor | Arbutin results in decreased expression of MDFI mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4239 | 
                        MFAP4
                         | 
                      microfibrillar-associated protein 4 | Arbutin results in decreased expression of MFAP4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 90007 | 
                        MIDN
                         | 
                      midnolin | Arbutin results in decreased expression of MIDN mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4288 | 
                        MKI67
                         KIA MIB-1  | 
                      marker of proliferation Ki-67 | Arbutin results in increased expression of MKI67 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 93380 | 
                        MMGT1
                         EMC5 TMEM32  | 
                      membrane magnesium transporter 1 | Arbutin results in increased expression of MMGT1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 245802 | 
                        MS4A6E
                         | 
                      membrane-spanning 4-domains, subfamily A, member 6E | Arbutin results in decreased expression of MS4A6E mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 25902 | 
                        MTHFD1L
                         FTHFSDC1 MTC1THFS dJ292B18.2  | 
                      methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3) | Arbutin results in decreased expression of MTHFD1L mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4597 | 
                        MVD
                         FP17780 MPD  | 
                      mevalonate (diphospho) decarboxylase (EC:4.1.1.33) | Arbutin results in decreased expression of MVD mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 140469 | 
                        MYO3B
                         | 
                      myosin IIIB (EC:2.7.11.1) | Arbutin results in decreased expression of MYO3B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 83988 | 
                        NCALD
                         | 
                      neurocalcin delta | Arbutin results in decreased expression of NCALD mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 257194 | 
                        NEGR1
                         DMML2433 IGLON4 KILON Ntra  | 
                      neuronal growth regulator 1 | Arbutin results in decreased expression of NEGR1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 129807 | 
                        NEU4
                         | 
                      sialidase 4 (EC:3.2.1.18) | Arbutin results in increased expression of NEU4 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 85407 | 
                        NKD1
                         Naked1  | 
                      naked cuticle homolog 1 (Drosophila) | Arbutin results in decreased expression of NKD1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9111 | 
                        NMI
                         | 
                      N-myc (and STAT) interactor | Arbutin results in increased expression of NMI mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 122945 | 
                        NOXRED1
                         C14orf148  | 
                      NADP-dependent oxidoreductase domain containing 1 | Arbutin results in decreased expression of NOXRED1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7025 | 
                        NR2F1
                         COUP-TFI EAR-3 EAR3 ERBAL3 NR2F2 SVP44 TCFCOUP1 TFCOUP1  | 
                      nuclear receptor subfamily 2, group F, member 1 | Arbutin results in increased expression of NR2F1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8828 | 
                        NRP2
                         NP2 NPN2 PRO2714 VEGF165R2  | 
                      neuropilin 2 | Arbutin results in increased expression of NRP2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 4909 | 
                        NTF4
                         GLC10 GLC1O NT-4 NT-4/5 NT-5 NT4 NT5 NTF5  | 
                      neurotrophin 4 | Arbutin results in decreased expression of NTF4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 283298 | 
                        OLFML1
                         UNQ564  | 
                      olfactomedin-like 1 | Arbutin results in decreased expression of OLFML1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23762 | 
                        OSBP2
                         HLM ORP-4 ORP4 OSBPL1 OSBPL4  | 
                      oxysterol binding protein 2 | Arbutin results in decreased expression of OSBP2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 114885 | 
                        OSBPL11
                         ORP-11 ORP11 OSBP12 TCCCIA00292  | 
                      oxysterol binding protein-like 11 | Arbutin results in increased expression of OSBPL11 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5013 | 
                        OTX1
                         | 
                      orthodenticle homeobox 1 | Arbutin results in decreased expression of OTX1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 11252 | 
                        PACSIN2
                         SDPII  | 
                      protein kinase C and casein kinase substrate in neurons 2 | Arbutin results in decreased expression of PACSIN2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8505 | 
                        PARG
                         PARG99  | 
                      poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) | Arbutin results in increased expression of PARG mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84108 | 
                        PCGF6
                         MBLR RNF134  | 
                      polycomb group ring finger 6 | Arbutin results in increased expression of PCGF6 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55251 | 
                        PCMTD2
                         C20orf36  | 
                      protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | Arbutin results in increased expression of PCMTD2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80003 | 
                        PCNXL2
                         | 
                      pecanex-like 2 (Drosophila) | Arbutin results in decreased expression of PCNXL2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5174 | 
                        PDZK1
                         CAP70 CLAMP NHERF-3 NHERF3 PDZD1  | 
                      PDZ domain containing 1 | Arbutin results in decreased expression of PDZK1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5196 | 
                        PF4
                         CXCL4 PF-4 SCYB4  | 
                      platelet factor 4 | Arbutin results in decreased expression of PF4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55276 | 
                        PGM2
                         | 
                      phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) | Arbutin results in increased expression of PGM2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9091 | 
                        PIGQ
                         GPI1 c407A10.1  | 
                      phosphatidylinositol glycan anchor biosynthesis, class Q (EC:2.4.1.198) | Arbutin results in decreased expression of PIGQ mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5300 | 
                        PIN1
                         DOD UBL5  | 
                      peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (EC:5.2.1.8) | Arbutin results in decreased expression of PIN1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23760 | 
                        PITPNB
                         PI-TP-beta PtdInsTP VIB1B  | 
                      phosphatidylinositol transfer protein, beta | Arbutin results in increased expression of PITPNB mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5314 | 
                        PKHD1
                         ARPKD FCYT TIGM1  | 
                      polycystic kidney and hepatic disease 1 (autosomal recessive) | Arbutin results in decreased expression of PKHD1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5427 | 
                        POLE2
                         DPE2  | 
                      polymerase (DNA directed), epsilon 2, accessory subunit (EC:2.7.7.7) | Arbutin results in increased expression of POLE2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51535 | 
                        PPHLN1
                         HSPC232  | 
                      periphilin 1 | Arbutin results in increased expression of PPHLN1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5553 | 
                        PRG2
                         BMPG MBP MBP1  | 
                      proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | Arbutin results in decreased expression of PRG2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5613 | 
                        PRKX
                         PKX1  | 
                      protein kinase, X-linked (EC:2.7.11.1) | Arbutin results in decreased expression of PRKX mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3275 | 
                        PRMT2
                         HRMT1L1  | 
                      protein arginine methyltransferase 2 (EC:2.1.1.125) | Arbutin results in decreased expression of PRMT2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 285800 | 
                        PRR18
                         | 
                      proline rich 18 | Arbutin results in decreased expression of PRR18 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5396 | 
                        PRRX1
                         AGOTC PHOX1 PMX1 PRX-1 PRX1  | 
                      paired related homeobox 1 | Arbutin results in decreased expression of PRRX1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5645 | 
                        PRSS2
                         TRY2 TRY8 TRYP2  | 
                      protease, serine, 2 (trypsin 2) (EC:3.4.21.4) | Arbutin results in decreased expression of PRSS2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5719 | 
                        PSMD13
                         HSPC027 Rpn9 S11 p40.5  | 
                      proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | Arbutin results in decreased expression of PSMD13 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5709 | 
                        PSMD3
                         P58 RPN3 S3 TSTA2  | 
                      proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | Arbutin results in decreased expression of PSMD3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 22930 | 
                        RAB3GAP1
                         P130 RAB3GAP RAB3GAP130 WARBM1  | 
                      RAB3 GTPase activating protein subunit 1 (catalytic) | Arbutin results in increased expression of RAB3GAP1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51560 | 
                        RAB6B
                         | 
                      RAB6B, member RAS oncogene family | Arbutin results in decreased expression of RAB6B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 153020 | 
                        RASGEF1B
                         GPIG4  | 
                      RasGEF domain family, member 1B | Arbutin results in decreased expression of RASGEF1B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10739 | 
                        RFPL2
                         RNF79  | 
                      ret finger protein-like 2 | Arbutin results in decreased expression of RFPL2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10738 | 
                        RFPL3
                         | 
                      ret finger protein-like 3 | Arbutin results in decreased expression of RFPL3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 727800 | 
                        RNF208
                         | 
                      ring finger protein 208 | Arbutin results in decreased expression of RNF208 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6197 | 
                        RPS6KA3
                         CLS HU-3 ISPK-1 MAPKAPK1B MRX19 RSK RSK2 S6K-alpha3 p90-RSK2 pp90RSK2  | 
                      ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) | Arbutin results in increased expression of RPS6KA3 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 54665 | 
                        RSBN1
                         ROSBIN RP11-324J2.1  | 
                      round spermatid basic protein 1 | Arbutin results in decreased expression of RSBN1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6291 | 
                        SAA4
                         C-SAA CSAA  | 
                      serum amyloid A4, constitutive | Arbutin results in decreased expression of SAA4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51097 | 
                        SCCPDH
                         NET11 RP11-439E19.2  | 
                      saccharopine dehydrogenase (putative) (EC:1.5.1.9) | Arbutin results in increased expression of SCCPDH mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6324 | 
                        SCN1B
                         ATFB13 BRGDA5 GEFSP1  | 
                      sodium channel, voltage-gated, type I, beta subunit | Arbutin results in increased expression of SCN1B mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6385 | 
                        SDC4
                         SYND4  | 
                      syndecan 4 | Arbutin results in decreased expression of SDC4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6406 | 
                        SEMG1
                         CT103 SEMG SGI dJ172H20.2  | 
                      semenogelin I | Arbutin results in decreased expression of SEMG1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 5104 | 
                        SERPINA5
                         PAI-3 PAI3 PCI PCI-B PLANH3 PROCI  | 
                      serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | Arbutin results in decreased expression of SERPINA5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 3053 | 
                        SERPIND1
                         D22S673 HC2 HCF2 HCII HLS2 LS2 THPH10  | 
                      serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | Arbutin results in decreased expression of SERPIND1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23451 | 
                        SF3B1
                         Hsh155 MDS PRP10 PRPF10 SAP155 SF3b155  | 
                      splicing factor 3b, subunit 1, 155kDa | Arbutin results in increased expression of SF3B1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6425 | 
                        SFRP5
                         SARP3  | 
                      secreted frizzled-related protein 5 | Arbutin results in decreased expression of SFRP5 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 118980 | 
                        SFXN2
                         | 
                      sideroflexin 2 | Arbutin results in decreased expression of SFXN2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6456 | 
                        SH3GL2
                         CNSA2 EEN-B1 SH3D2A SH3P4  | 
                      SH3-domain GRB2-like 2 | Arbutin results in decreased expression of SH3GL2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23309 | 
                        SIN3B
                         | 
                      SIN3 transcription regulator family member B | Arbutin results in decreased expression of SIN3B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9058 | 
                        SLC13A2
                         NADC1 NaCT NaDC-1 SDCT1  | 
                      solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 | Arbutin results in decreased expression of SLC13A2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51296 | 
                        SLC15A3
                         OCTP PHT2 PTR3  | 
                      solute carrier family 15 (oligopeptide transporter), member 3 | Arbutin results in decreased expression of SLC15A3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6571 | 
                        SLC18A2
                         SVAT SVMT VAT2 VMAT2  | 
                      solute carrier family 18 (vesicular monoamine transporter), member 2 | Arbutin results in decreased expression of SLC18A2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 151295 | 
                        SLC23A3
                         E2BP3 SVCT3 Yspl1  | 
                      solute carrier family 23, member 3 | Arbutin results in increased expression of SLC23A3 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 83884 | 
                        SLC25A2
                         ORC2 ORNT2  | 
                      solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 | Arbutin results in decreased expression of SLC25A2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10999 | 
                        SLC27A4
                         ACSVL4 FATP4 IPS  | 
                      solute carrier family 27 (fatty acid transporter), member 4 (EC:6.2.1.-) | Arbutin results in decreased expression of SLC27A4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84889 | 
                        SLC7A3
                         ATRC3 CAT-3 CAT3  | 
                      solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 | Arbutin results in decreased expression of SLC7A3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 81796 | 
                        SLCO5A1
                         OATP-J OATP-RP4 OATP5A1 OATPRP4 SLC21A15  | 
                      solute carrier organic anion transporter family, member 5A1 | Arbutin results in decreased expression of SLCO5A1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 79753 | 
                        SNIP1
                         PMRED  | 
                      Smad nuclear interacting protein 1 | Arbutin results in decreased expression of SNIP1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 122809 | 
                        SOCS4
                         SOCS7  | 
                      suppressor of cytokine signaling 4 | Arbutin results in decreased expression of SOCS4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 221178 | 
                        SPATA13
                         ARHGEF29 ASEF2  | 
                      spermatogenesis associated 13 | Arbutin results in increased expression of SPATA13 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 64847 | 
                        SPATA20
                         SSP411 Tisp78  | 
                      spermatogenesis associated 20 | Arbutin results in decreased expression of SPATA20 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 10558 | 
                        SPTLC1
                         HSAN1 HSN1 LBC1 LCB1 SPT1 SPTI  | 
                      serine palmitoyltransferase, long chain base subunit 1 (EC:2.3.1.50) | Arbutin results in increased expression of SPTLC1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9754 | 
                        STARD8
                         ARHGAP38 DLC3 STARTGAP3  | 
                      StAR-related lipid transfer (START) domain containing 8 | Arbutin results in decreased expression of STARD8 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 85360 | 
                        SYDE1
                         7h3  | 
                      synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | Arbutin results in decreased expression of SYDE1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 8189 | 
                        SYMPK
                         SPK SYM  | 
                      symplekin | Arbutin results in decreased expression of SYMPK mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6886 | 
                        TAL1
                         SCL TCL5 bHLHa17 tal-1  | 
                      T-cell acute lymphocytic leukemia 1 | Arbutin results in decreased expression of TAL1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23435 | 
                        TARDBP
                         ALS10 TDP-43  | 
                      TAR DNA binding protein | Arbutin results in increased expression of TARDBP mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6938 | 
                        TCF12
                         CRS3 HEB HTF4 HsT17266 bHLHb20  | 
                      transcription factor 12 | Arbutin results in increased expression of TCF12 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 6947 | 
                        TCN1
                         TC-1 TC1 TCI  | 
                      transcobalamin I (vitamin B12 binding protein, R binder family) | Arbutin results in decreased expression of TCN1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 26136 | 
                        TES
                         TESS TESS-2  | 
                      testis derived transcript (3 LIM domains) | Arbutin results in increased expression of TES mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 56156 | 
                        TEX13B
                         TGC3B TSGA5  | 
                      testis expressed 13B | Arbutin results in decreased expression of TEX13B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7043 | 
                        TGFB3
                         ARVD ARVD1 TGF-beta3  | 
                      transforming growth factor, beta 3 | Arbutin results in decreased expression of TGFB3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7092 | 
                        TLL1
                         ASD6 TLL  | 
                      tolloid-like 1 (EC:3.4.24.-) | Arbutin results in decreased expression of TLL1 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 25789 | 
                        TMEM59L
                         BSMAP C19orf4  | 
                      transmembrane protein 59-like | Arbutin results in decreased expression of TMEM59L mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 54863 | 
                        TOR4A
                         C9orf167  | 
                      torsin family 4, member A | Arbutin results in decreased expression of TOR4A mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9697 | 
                        TRAM2
                         | 
                      translocation associated membrane protein 2 | Arbutin results in decreased expression of TRAM2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 11181 | 
                        TREH
                         TRE TREA  | 
                      trehalase (brush-border membrane glycoprotein) (EC:3.2.1.28) | Arbutin results in decreased expression of TREH mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7248 | 
                        TSC1
                         LAM TSC  | 
                      tuberous sclerosis 1 | Arbutin results in increased expression of TSC1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9819 | 
                        TSC22D2
                         TILZ4a TILZ4b TILZ4c  | 
                      TSC22 domain family, member 2 | Arbutin results in decreased expression of TSC22D2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 128553 | 
                        TSHZ2
                         C20orf17 OVC10-2 TSH2 ZABC2 ZNF218  | 
                      teashirt zinc finger homeobox 2 | Arbutin results in decreased expression of TSHZ2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 118491 | 
                        TTC18
                         | 
                      tetratricopeptide repeat domain 18 | Arbutin results in decreased expression of TTC18 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55001 | 
                        TTC22
                         | 
                      tetratricopeptide repeat domain 22 | Arbutin results in decreased expression of TTC22 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7289 | 
                        TULP3
                         TUBL3  | 
                      tubby like protein 3 | Arbutin results in decreased expression of TULP3 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51619 | 
                        UBE2D4
                         HBUCE1  | 
                      ubiquitin-conjugating enzyme E2D 4 (putative) (EC:6.3.2.19) | Arbutin results in decreased expression of UBE2D4 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9040 | 
                        UBE2M
                         UBC-RS2 UBC12 hUbc12  | 
                      ubiquitin-conjugating enzyme E2M (EC:6.3.2.19) | Arbutin results in decreased expression of UBE2M mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 29979 | 
                        UBQLN1
                         DA41 DSK2 PLIC-1 UBQN XDRP1  | 
                      ubiquilin 1 | Arbutin results in increased expression of UBQLN1 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84101 | 
                        USP44
                         | 
                      ubiquitin specific peptidase 44 (EC:3.4.19.12) | Arbutin results in decreased expression of USP44 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51118 | 
                        UTP11L
                         CGI94  | 
                      UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) | Arbutin results in increased expression of UTP11L mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 157680 | 
                        VPS13B
                         CHS1 COH1  | 
                      vacuolar protein sorting 13 homolog B (yeast) | Arbutin results in decreased expression of VPS13B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 23339 | 
                        VPS39
                         TLP VAM6 hVam6p  | 
                      vacuolar protein sorting 39 homolog (S. cerevisiae) | Arbutin results in increased expression of VPS39 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 146177 | 
                        VWA3A
                         | 
                      von Willebrand factor A domain containing 3A | Arbutin results in decreased expression of VWA3A mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 126820 | 
                        WDR63
                         DIC3 NYD-SP29 RP11-507C22.2  | 
                      WD repeat domain 63 | Arbutin results in decreased expression of WDR63 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 80326 | 
                        WNT10A
                         OODD SSPS STHAG4  | 
                      wingless-type MMTV integration site family, member 10A | Arbutin results in decreased expression of WNT10A mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 9502 | 
                        XAGE2
                         CT12.2 GAGED3 XAGE-2  | 
                      X antigen family, member 2 | Arbutin results in increased expression of XAGE2 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 26137 | 
                        ZBTB20
                         DPZF HOF ODA-8S ZNF288  | 
                      zinc finger and BTB domain containing 20 | Arbutin results in increased expression of ZBTB20 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51043 | 
                        ZBTB7B
                         THPOK ZBTB15 ZFP-67 ZFP67 ZNF857B c-KROX hcKROX  | 
                      zinc finger and BTB domain containing 7B | Arbutin results in decreased expression of ZBTB7B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 51201 | 
                        ZDHHC2
                         DHHC2 ZNF372  | 
                      zinc finger, DHHC-type containing 2 (EC:2.3.1.225) | Arbutin results in decreased expression of ZDHHC2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 55888 | 
                        ZKSCAN7
                         ZFP ZNF167 ZNF448 ZNF64 ZSCAN39  | 
                      zinc finger with KRAB and SCAN domains 7 | Arbutin results in decreased expression of ZKSCAN7 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7700 | 
                        ZNF141
                         D4S90 PAPA6 pHZ-44  | 
                      zinc finger protein 141 | Arbutin results in decreased expression of ZNF141 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 162967 | 
                        ZNF320
                         ZFPL  | 
                      zinc finger protein 320 | Arbutin results in decreased expression of ZNF320 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 117608 | 
                        ZNF354B
                         KID2  | 
                      zinc finger protein 354B | Arbutin results in decreased expression of ZNF354B mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7592 | 
                        ZNF41
                         MRX89  | 
                      zinc finger protein 41 | Arbutin results in decreased expression of ZNF41 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 84330 | 
                        ZNF414
                         ZFP414  | 
                      zinc finger protein 414 | Arbutin results in decreased expression of ZNF414 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 158399 | 
                        ZNF483
                         ZKSCAN16 ZSCAN48  | 
                      zinc finger protein 483 | Arbutin results in decreased expression of ZNF483 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 162968 | 
                        ZNF497
                         | 
                      zinc finger protein 497 | Arbutin results in decreased expression of ZNF497 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 93474 | 
                        ZNF670
                         | 
                      zinc finger protein 670 | Arbutin results in increased expression of ZNF670 mRNA | 
                        increases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 347344 | 
                        ZNF81
                         HFZ20 MRX45 dJ54B20.6  | 
                      zinc finger protein 81 | Arbutin results in decreased expression of ZNF81 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| D001104 | 7783 | 
                        ZP2
                         ZPA Zp-2  | 
                      zona pellucida glycoprotein 2 (sperm receptor) | Arbutin results in decreased expression of ZP2 mRNA | 
                        decreases expression
                         | 
                      mRNA | 
                        17103032
                         | 
                    
| OMIM | preferred title | UniProt | 
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness | 
                            P14679
                             | 
                        
| #203100 | Albinism, oculocutaneous, type ia; oca1a | 
                            P14679
                             | 
                        
| #606952 | Albinism, oculocutaneous, type ib; oca1b | 
                            P14679
                             | 
                        
| #114500 | Colorectal cancer; crc | 
                            P84022
                             | 
                        
| #137800 | Glioma susceptibility 1; glm1 | 
                            O75874
                             | 
                        
| #613795 | Loeys-dietz syndrome, type 3; lds3 | 
                            P84022
                             | 
                        
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | 
                            P14679
                             |