PCIDB

KNApSAcK Metabolite C00002645

Metabolite

KNApSAcK Entry

id C00002645
Name p-Cresol / 4-Methylphenol
CAS RN 106-44-5
Standard InChI InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3
Standard InChI (Main Layer) InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1546

Link

ChEMBL

By standard InChI CHEMBL16645
By standard InChI Main Layer CHEMBL16645

KEGG

By LinkDB C01468

CTD

By CAS RN C032538

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P50225 Sulfotransferase 1A1 Enzyme CHEMBL16645 CHEMBL1743314 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL16645 CHEMBL1908086 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL16645 CHEMBL2114835 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL16645 CHEMBL2114842 (1)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL16645 CHEMBL648291 (1) CHEMBL643382 (1)
1 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL16645 CHEMBL1908083 (3)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL16645 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL16645 CHEMBL1794560 (1)
3 / 4

CTD interaction (23)

compound gene gene name gene description interaction interaction type form reference
pmid
C032538 213 ALB
PRO0883
PRO0903
PRO1341
albumin 4-cresol binds to ALB protein affects binding
protein 11334365
C032538 6376 CX3CL1
ABCD-3
C3Xkine
CXC3
CXC3C
NTN
NTT
SCYD1
fractalkine
neurotactin
chemokine (C-X3-C motif) ligand 1 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein] decreases reaction
/ increases expression
protein 16954166
C032538 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased metabolism of 4-cresol increases metabolic processing
protein 16174805
C032538 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) CYP2D6 protein results in increased metabolism of 4-cresol increases metabolic processing
protein 16174805
C032538 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of 4-cresol increases metabolic processing
protein 16174805
C032538 50848 F11R
CD321
JAM
JAM1
JAMA
JCAM
KAT
PAM-1
F11 receptor 4-cresol results in decreased expression of F11R protein decreases expression
protein 16954166
C032538 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 12427124
C032538 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 12427124
C032538 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein] decreases reaction
/ increases expression
protein 16954166
C032538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 12427124
C032538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-cresol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 12427124
C032538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 12427124
C032538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 4-cresol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 12427124
C032538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 12427124
C032538 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 4-cresol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12427124
C032538 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 12427124
C032538 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 4-cresol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12427124

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#112100 Yt blood group antigen P22303

KEGG DISEASE (4)

KEGG disease name UniProt
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002318 C032538 Cardiovascular Diseases marker/mechanism
18305466
20430946
D003873 C032538 Dermatitis, Exfoliative marker/mechanism
16930241
D006965 C032538 Hyperplasia marker/mechanism
19114085
D007674 C032538 Kidney Diseases marker/mechanism
19114085