KNApSAcK Metabolite C00002656
Metabolite
KNApSAcK Entry
| id | C00002656 |
|---|---|
| Name | Hydroquinone / 1,4-Benzenediol |
| CAS RN | 123-31-9 |
| Standard InChI | InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H |
| Standard InChI (Main Layer) | InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H |
Cluster
| Phytochemical cluster | No. 82 |
|---|---|
| KCF-S cluster | No. 1590 |
Link
ChEMBL
| By standard InChI | CHEMBL537 |
|---|---|
| By standard InChI Main Layer | CHEMBL537 |
KEGG
| By LinkDB | C00530 |
|---|
CTD
| By CAS RN | C031927 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 5 |
| Spermatophyta | 2 |
| rosids | 1 |
| Liliopsida | 1 |
| eudicotyledons | 1 |
Family
| family name | count |
|---|---|
| Ericaceae | 2 |
| Apiaceae | 2 |
| Orchidaceae | 1 |
| Asteraceae | 1 |
| Proteaceae | 1 |
| Podocarpaceae | 1 |
| Rosaceae | 1 |
| Pinaceae | 1 |
List (11)
* NCBI
Human Protein / Gene in interaction
55 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | CHEMBL537 |
CHEMBL1614316
(1)
CHEMBL1613805
(1)
CHEMBL1614009 (1) |
0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | CHEMBL537 |
CHEMBL1908087
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL537 |
CHEMBL1794367
(1)
CHEMBL2114784
(1)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL537 |
CHEMBL1794499
(1)
|
2 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL537 |
CHEMBL1014033
(1)
|
0 / 3 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | CHEMBL537 |
CHEMBL992755
(1)
|
0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | CHEMBL537 |
CHEMBL992754
(1)
|
0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | CHEMBL537 |
CHEMBL992757
(1)
|
0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL537 |
CHEMBL1794524
(1)
CHEMBL1794552
(1)
|
0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL537 |
CHEMBL1738600
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL537 |
CHEMBL1614310
(1)
CHEMBL1614544
(2)
|
11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL537 |
CHEMBL1794399
(1)
|
3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL537 |
CHEMBL1794371
(1)
CHEMBL1794471
(1)
|
0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL537 |
CHEMBL933690
(1)
CHEMBL991856
(1)
|
1 / 2 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL537 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | CHEMBL537 |
CHEMBL1908084
(1)
|
0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | CHEMBL537 |
CHEMBL992756
(1)
|
0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | CHEMBL537 |
CHEMBL981174
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL537 |
CHEMBL1614458
(1)
|
0 / 0 |
| P68871 | Hemoglobin subunit beta | Secreted protein | CHEMBL537 |
CHEMBL1614204
(1)
CHEMBL1614225
(1)
|
4 / 4 |
| O43570 | Carbonic anhydrase 12 | Lyase | CHEMBL537 |
CHEMBL992759
(1)
|
1 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL537 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL537 |
CHEMBL1794486
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL537 |
CHEMBL1613941
(1)
CHEMBL2114843
(2)
CHEMBL2114780 (1) |
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL537 |
CHEMBL1613838
(1)
|
0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | CHEMBL537 |
CHEMBL2114835
(1)
|
0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | CHEMBL537 |
CHEMBL933689
(1)
CHEMBL991855
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL537 |
CHEMBL1738610
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL537 |
CHEMBL1794382
(1)
|
0 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL537 |
CHEMBL1794415
(1)
CHEMBL1794437
(1)
|
0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | CHEMBL537 |
CHEMBL992758
(1)
|
0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL537 |
CHEMBL1613910
(1)
CHEMBL1614227
(2)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL537 |
CHEMBL1614038
(3)
|
2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL537 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | CHEMBL537 |
CHEMBL1614171
(1)
|
5 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL537 |
CHEMBL2114842
(1)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL537 |
CHEMBL1738675
(1)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL537 |
CHEMBL1794364
(1)
CHEMBL1794542
(1)
|
1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL537 |
CHEMBL1614274
(1)
CHEMBL1613823
(1)
|
0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL537 |
CHEMBL1614240
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL537 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL537 |
CHEMBL1614250
(1)
|
4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | CHEMBL537 |
CHEMBL1738402
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL537 |
CHEMBL2114890
(1)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL537 |
CHEMBL1794560
(1)
|
3 / 4 |
| P07451 | Carbonic anhydrase 3 | Lyase | CHEMBL537 |
CHEMBL991857
(1)
|
0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | CHEMBL537 |
CHEMBL2114849
(1)
|
0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | CHEMBL537 |
CHEMBL991858
(1)
|
1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL537 |
CHEMBL1613914
(1)
|
0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL537 |
CHEMBL1613829
(1)
|
0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | CHEMBL537 |
CHEMBL1614086
(1)
CHEMBL1614034
(1)
|
1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL537 |
CHEMBL1738442
(2)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL537 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL537 |
CHEMBL1614531
(1)
|
1 / 3 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL537 |
CHEMBL2114738
(1)
|
0 / 0 |
CTD interaction (253)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C031927 | 64782 |
AEN
ISG20L1 pp12744 |
apoptosis enhancing nuclease | hydroquinone results in increased expression of AEN mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 217 |
ALDH2
ALDH-E2 ALDHI ALDM |
aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) | hydroquinone results in increased expression of ALDH2 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 396 |
ARHGDIA
GDIA1 NPHS8 RHOGDI RHOGDI-1 |
Rho GDP dissociation inhibitor (GDI) alpha | hydroquinone affects the expression of ARHGDIA protein |
affects expression
|
protein |
17181942
|
| C031927 | 468 |
ATF4
CREB-2 CREB2 TAXREB67 TXREB |
activating transcription factor 4 | hydroquinone results in increased expression of ATF4 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 572 |
BAD
BBC2 BCL2L8 |
BCL2-associated agonist of cell death | hydroquinone results in decreased expression of BAD mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | hydroquinone results in increased expression of BBC3 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | hydroquinone results in increased expression of BIRC3 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 664 |
BNIP3
NIP3 |
BCL2/adenovirus E1B 19kDa interacting protein 3 | hydroquinone results in decreased expression of BNIP3 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 79866 |
BORA
C13orf34 |
bora, aurora kinase A activator | hydroquinone results in decreased expression of BORA mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 7832 |
BTG2
PC3 TIS21 |
BTG family, member 2 | hydroquinone results in increased expression of BTG2 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
15816534
|
| C031927 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | hydroquinone results in decreased activity of CASP3 protein |
decreases activity
|
protein |
22960397
|
| C031927 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | hydroquinone results in decreased expression of CASP3 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | hydroquinone results in increased activity of CASP3 protein |
increases activity
|
protein |
15816534
20946948 |
| C031927 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | hydroquinone results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
15777082
22302391 |
| C031927 | 839 |
CASP6
MCH2 |
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) | hydroquinone results in decreased expression of CASP6 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | hydroquinone results in decreased activity of CASP7 protein |
decreases activity
|
protein |
22960397
|
| C031927 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | hydroquinone results in increased cleavage of CASP7 protein |
increases cleavage
|
protein |
19064679
|
| C031927 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein] |
decreases reaction
/ increases cleavage |
protein |
19064679
|
| C031927 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | MPO protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein] |
affects reaction
/ increases cleavage |
protein |
15777082
|
| C031927 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | hydroquinone results in decreased expression of CASP9 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | hydroquinone results in increased activity of CASP9 protein |
increases activity
|
protein |
15816534
20946948 |
| C031927 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | hydroquinone results in increased cleavage of CASP9 protein |
increases cleavage
|
protein |
15777082
22302391 |
| C031927 | 847 |
CAT
|
catalase (EC:1.11.1.6) | CAT protein results in decreased susceptibility to hydroquinone |
decreases response to substance
|
protein |
10193577
|
| C031927 | 6356 |
CCL11
SCYA11 |
chemokine (C-C motif) ligand 11 | hydroquinone results in increased expression of CCL11 protein |
increases expression
|
protein |
17572062
|
| C031927 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | hydroquinone results in decreased secretion of CCL2 protein |
decreases secretion
|
protein |
22302391
|
| C031927 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | hydroquinone results in increased expression of CCL2 protein |
increases expression
|
protein |
17572062
|
| C031927 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | hydroquinone results in increased secretion of CCL2 protein |
increases secretion
|
protein |
20946948
|
| C031927 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | hydroquinone results in increased expression of CCL3 protein |
increases expression
|
protein |
17572062
|
| C031927 | 6351 |
CCL4
ACT2 AT744.1 G-26 HC21 LAG-1 LAG1 MIP-1-beta MIP1B MIP1B1 SCYA2 SCYA4 |
chemokine (C-C motif) ligand 4 | hydroquinone results in increased expression of CCL4 protein |
increases expression
|
protein |
17572062
18353026 |
| C031927 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | hydroquinone results in increased expression of CCL5 protein |
increases expression
|
protein |
17572062
|
| C031927 | 9134 |
CCNE2
CYCE2 |
cyclin E2 | hydroquinone results in increased expression of CCNE2 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 899 |
CCNF
FBX1 FBXO1 |
cyclin F | hydroquinone results in decreased expression of CCNF mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 942 |
CD86
B7-2 B7.2 B70 CD28LG2 LAB72 |
CD86 molecule | hydroquinone results in increased expression of CD86 protein |
increases expression
|
protein |
19665512
|
| C031927 | 157313 |
CDCA2
Repo-Man |
cell division cycle associated 2 | hydroquinone results in decreased expression of CDCA2 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | hydroquinone results in increased expression of CDKN1A mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 1058 |
CENPA
CENP-A CenH3 |
centromere protein A | hydroquinone results in decreased expression of CENPA mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | hydroquinone results in increased expression of COL1A1 protein |
increases expression
|
protein |
18055817
|
| C031927 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 1282 |
COL4A1
HANAC ICH POREN1 arresten |
collagen, type IV, alpha 1 | hydroquinone results in decreased expression of COL4A1 mRNA |
decreases expression
|
mRNA |
18055817
|
| C031927 | 1282 |
COL4A1
HANAC ICH POREN1 arresten |
collagen, type IV, alpha 1 | hydroquinone results in increased expression of COL4A1 protein |
increases expression
|
protein |
18055817
|
| C031927 | 1282 |
COL4A1
HANAC ICH POREN1 arresten |
collagen, type IV, alpha 1 | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 1282 |
COL4A1
HANAC ICH POREN1 arresten |
collagen, type IV, alpha 1 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 1282 |
COL4A1
HANAC ICH POREN1 arresten |
collagen, type IV, alpha 1 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 1436 |
CSF1R
C-FMS CD115 CSF-1R CSFR FIM2 FMS HDLS M-CSF-R |
colony stimulating factor 1 receptor (EC:2.7.10.1) | hydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
affects cotreatment
/ increases abundance / increases reaction |
protein |
7884313
|
| C031927 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK1 protein |
affects cotreatment
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK3 protein |
affects cotreatment
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 6387 |
CXCL12
IRH PBSF SCYB12 SDF1 TLSF TPAR1 SDF1A SDF1B |
chemokine (C-X-C motif) ligand 12 | hydroquinone results in decreased expression of CXCL12 mRNA |
decreases expression
|
mRNA |
22960397
|
| C031927 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | hydroquinone affects the localization of CYCS protein |
affects localization
|
protein |
15777082
15816534 |
| C031927 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP1A1 protein affects the susceptibility to hydroquinone |
affects response to substance
|
protein |
8242868
|
| C031927 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | hydroquinone results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | hydroquinone results in increased expression of CYP1B1 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 24300 | CYP2B1 protein affects the susceptibility to hydroquinone |
affects response to substance
|
protein |
8242868
|
||
| C031927 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
increases chemical synthesis
/ increases metabolic processing |
protein |
21402134
|
| C031927 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroquinone |
affects chemical synthesis
/ affects metabolic processing |
protein |
15051535
|
| C031927 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
increases chemical synthesis
/ increases metabolic processing |
protein |
21402134
|
| C031927 | 1577 |
CYP3A5
CP35 CYPIIIA5 P450PCN3 PCN3 |
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) | [CYP3A5 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
increases chemical synthesis
/ increases metabolic processing |
protein |
21402134
|
| C031927 | 3491 |
CYR61
CCN1 GIG1 IGFBP10 |
cysteine-rich, angiogenic inducer, 61 | hydroquinone affects the expression of CYR61 mRNA |
affects expression
|
mRNA |
15452088
|
| C031927 | 1611 |
DAP
|
death-associated protein | hydroquinone results in decreased expression of DAP mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 1649 |
DDIT3
CEBPZ CHOP CHOP-10 CHOP10 GADD153 |
DNA-damage-inducible transcript 3 | hydroquinone results in increased expression of DDIT3 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 54541 |
DDIT4
Dig2 REDD-1 REDD1 |
DNA-damage-inducible transcript 4 | hydroquinone results in increased expression of DDIT4 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 22943 |
DKK1
DKK-1 SK |
dickkopf WNT signaling pathway inhibitor 1 | hydroquinone affects the expression of DKK1 mRNA |
affects expression
|
mRNA |
22960397
|
| C031927 | 3301 |
DNAJA1
DJ-2 DjA1 HDJ2 HSDJ HSJ2 HSPF4 NEDD7 hDJ-2 |
DnaJ (Hsp40) homolog, subfamily A, member 1 | hydroquinone results in increased expression of DNAJA1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 3337 |
DNAJB1
HSPF1 Hdj1 Hsp40 RSPH16B Sis1 |
DnaJ (Hsp40) homolog, subfamily B, member 1 | hydroquinone results in increased expression of DNAJB1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 1786 |
DNMT1
ADCADN AIM CXXC9 DNMT HSN1E MCMT |
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) | hydroquinone results in decreased expression of DNMT1 mRNA |
decreases expression
|
mRNA |
22245671
|
| C031927 | 1788 |
DNMT3A
DNMT3A2 M.HsaIIIA |
DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37) | hydroquinone results in decreased expression of DNMT3A mRNA |
decreases expression
|
mRNA |
22245671
|
| C031927 | 1789 |
DNMT3B
ICF ICF1 M.HsaIIIB |
DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) | hydroquinone results in decreased expression of DNMT3B mRNA |
decreases expression
|
mRNA |
22245671
|
| C031927 | 1999 |
ELF3
EPR-1 ERT ESE-1 ESX |
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | hydroquinone results in increased expression of ELF3 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 8772 |
FADD
MORT1 |
Fas (TNFRSF6)-associated via death domain | hydroquinone results in decreased expression of FADD mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 81610 |
FAM83D
C20orf129 CHICA dJ616B8.3 |
family with sequence similarity 83, member D | hydroquinone results in decreased expression of FAM83D mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 26271 |
FBXO5
EMI1 FBX5 Fbxo31 |
F-box protein 5 | hydroquinone results in decreased expression of FBXO5 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 2335 |
FN1
CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF |
fibronectin 1 | hydroquinone affects the expression of FN1 mRNA |
affects expression
|
mRNA |
15452088
|
| C031927 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | hydroquinone results in decreased expression of FOS mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 2495 |
FTH1
FHC FTH FTHL6 PIG15 PLIF |
ferritin, heavy polypeptide 1 (EC:1.16.3.1) | hydroquinone results in increased expression of FTH1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 1647 |
GADD45A
DDIT1 GADD45 |
growth arrest and DNA-damage-inducible, alpha | hydroquinone results in increased expression of GADD45A mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 2623 |
GATA1
ERYF1 GATA-1 GF-1 GF1 NF-E1 NFE1 XLANP XLTDA XLTT |
GATA binding protein 1 (globin transcription factor 1) | hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C031927 | 2623 |
GATA1
ERYF1 GATA-1 GF-1 GF1 NF-E1 NFE1 XLANP XLTDA XLTT |
GATA binding protein 1 (globin transcription factor 1) | hydroquinone results in decreased expression of GATA1 mRNA |
decreases expression
|
mRNA |
21414390
|
| C031927 | 2624 |
GATA2
DCML MONOMAC NFE1B |
GATA binding protein 2 | hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA] |
decreases expression
/ increases reaction |
mRNA |
21414390
|
| C031927 | 2624 |
GATA2
DCML MONOMAC NFE1B |
GATA binding protein 2 | hydroquinone results in decreased expression of GATA2 mRNA |
decreases expression
|
mRNA |
21414390
|
| C031927 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | hydroquinone results in increased expression of GCLM protein |
increases expression
|
protein |
21059386
|
| C031927 | 9518 |
GDF15
GDF-15 MIC-1 MIC1 NAG-1 PLAB PTGFB |
growth differentiation factor 15 | hydroquinone results in increased expression of GDF15 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 2937 |
GSS
GSHS |
glutathione synthetase (EC:6.3.2.3) | hydroquinone results in increased expression of GSS protein |
increases expression
|
protein |
21059386
|
| C031927 | 2937 |
GSS
GSHS |
glutathione synthetase (EC:6.3.2.3) | NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of GSS protein] |
affects reaction
/ increases expression |
protein |
21059386
|
| C031927 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | GSTM1 gene polymorphism affects the susceptibility to hydroquinone |
affects response to substance
|
gene |
15141365
|
| C031927 | 2993 |
GYPA
CD235a GPA GPErik GPSAT HGpMiV HGpMiXI HGpSta(C) MN MNS PAS-2 |
glycophorin A (MNS blood group) | hydroquinone results in decreased expression of GYPA protein |
decreases expression
|
protein |
21414390
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | hydroquinone affects the localization of H2AFX protein modified form |
affects localization
|
protein |
20036648
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | hydroquinone results in increased expression of H2AFX protein alternative form |
increases expression
|
protein |
21267443
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | hydroquinone results in increased phosphorylation of H2AFX protein |
increases phosphorylation
|
protein |
18835433
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | [POLH mutant form results in increased susceptibility to hydroquinone] which results in increased expression of H2AFX protein |
increases expression
/ increases response to substance |
protein |
22981619
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | WRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AFX protein alternative form] |
increases expression
/ increases reaction |
protein |
21267443
|
| C031927 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | WRN protein affects the reaction [hydroquinone results in increased expression of H2AFX protein] |
affects reaction
/ increases expression |
protein |
17875398
|
| C031927 | 3043 |
HBB
CD113t-C beta-globin |
hemoglobin, beta | hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C031927 | 3009 |
HIST1H1B
H1 H1.5 H1B H1F5 H1s-3 |
histone cluster 1, H1b | hydroquinone results in decreased expression of HIST1H1B mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 3007 |
HIST1H1D
H1.3 H1D H1F3 H1s-2 |
histone cluster 1, H1d | hydroquinone results in decreased expression of HIST1H1D mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 3008 |
HIST1H1E
H1.4 H1E H1F4 H1s-4 dJ221C16.5 |
histone cluster 1, H1e | hydroquinone results in decreased expression of HIST1H1E mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 85235 |
HIST1H2AH
H2A/S H2AFALii H2AH dJ86C11.1 |
histone cluster 1, H2ah | hydroquinone results in decreased expression of HIST1H2AH mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8329 |
HIST1H2AI
H2A/c H2AFC |
histone cluster 1, H2ai | hydroquinone results in decreased expression of HIST1H2AI mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8331 |
HIST1H2AJ
H2A/E H2AFE dJ160A22.4 |
histone cluster 1, H2aj | hydroquinone results in decreased expression of HIST1H2AJ mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8358 |
HIST1H3B
H3/l H3FL |
histone cluster 1, H3b | hydroquinone results in decreased expression of HIST1H3B mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8352 |
HIST1H3C
H3.1 H3/c H3FC |
histone cluster 1, H3c | hydroquinone results in decreased expression of HIST1H3C mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8359 |
HIST1H4A
H4FA |
histone cluster 1, H4a | hydroquinone results in decreased expression of HIST1H4A mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8366 |
HIST1H4B
H4/I H4FI |
histone cluster 1, H4b | hydroquinone results in decreased expression of HIST1H4B mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8364 |
HIST1H4C
H4/g H4FG dJ221C16.1 |
histone cluster 1, H4c | hydroquinone results in decreased expression of HIST1H4C mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8367 |
HIST1H4E
H4/j H4FJ |
histone cluster 1, H4e | hydroquinone results in decreased expression of HIST1H4E mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8361 |
HIST1H4F
H4 H4/c H4FC |
histone cluster 1, H4f | hydroquinone results in decreased expression of HIST1H4F mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8365 |
HIST1H4H
H4/h H4FH |
histone cluster 1, H4h | hydroquinone results in decreased expression of HIST1H4H mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8362 |
HIST1H4K
H4/d H4F2iii H4FD dJ160A22.1 |
histone cluster 1, H4k | hydroquinone results in decreased expression of HIST1H4K mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8337 |
HIST2H2AA3
H2A H2A.2 H2A/O H2A/q H2AFO H2a-615 HIST2H2AA |
histone cluster 2, H2aa3 | hydroquinone results in decreased expression of HIST2H2AA3 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 317772 |
HIST2H2AB
H2AB |
histone cluster 2, H2ab | hydroquinone results in decreased expression of HIST2H2AB mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8338 |
HIST2H2AC
H2A H2A-GL101 H2A/q H2AFQ |
histone cluster 2, H2ac | hydroquinone results in decreased expression of HIST2H2AC mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8370 |
HIST2H4A
FO108 H4 H4/n H4F2 H4FN HIST2H4 |
histone cluster 2, H4a | hydroquinone results in decreased expression of HIST2H4A mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 55355 |
HJURP
FAKTS URLC9 hFLEG1 |
Holliday junction recognition protein | hydroquinone results in decreased expression of HJURP mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 3145 |
HMBS
PBG-D PBGD PORC UPS |
hydroxymethylbilane synthase (EC:2.5.1.61) | hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C031927 | 3148 |
HMGB2
HMG2 |
high mobility group box 2 | hydroquinone results in decreased expression of HMGB2 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | hydroquinone results in increased expression of HMOX1 protein |
increases expression
|
protein |
21059386
|
| C031927 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of HMOX1 protein] |
affects reaction
/ increases expression |
protein |
21059386
|
| C031927 | 3306 |
HSPA2
HSP70-2 HSP70-3 |
heat shock 70kDa protein 2 | hydroquinone results in increased expression of HSPA2 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 219844 |
HYLS1
HLS |
hydrolethalus syndrome 1 | hydroquinone results in decreased expression of HYLS1 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | hydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
17572062
|
| C031927 | 3558 |
IL2
IL-2 TCGF lymphokine |
interleukin 2 | hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] |
decreases reaction
/ increases expression |
protein |
9571986
|
| C031927 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | hydroquinone results in decreased secretion of IL6 protein |
decreases secretion
|
protein |
22302391
|
| C031927 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | hydroquinone results in decreased secretion of IL8 protein |
decreases secretion
|
protein |
22302391
|
| C031927 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | hydroquinone results in increased expression of IL8 protein |
increases expression
|
protein |
15356918
17572062 |
| C031927 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | hydroquinone results in increased secretion of IL8 protein |
increases secretion
|
protein |
17118622
20946948 |
| C031927 | 3688 |
ITGB1
CD29 FNRB GPIIA MDF2 MSK12 VLA-BETA VLAB |
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | hydroquinone results in decreased expression of ITGB1 mRNA |
decreases expression
|
mRNA |
19148301
|
| C031927 | 3689 |
ITGB2
CD18 LAD LCAMB LFA-1 MAC-1 MF17 MFI7 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | hydroquinone results in decreased expression of ITGB2 mRNA |
decreases expression
|
mRNA |
19148301
|
| C031927 | 182 |
JAG1
AGS AHD AWS CD339 HJ1 JAGL1 |
jagged 1 | hydroquinone results in decreased expression of JAG1 mRNA |
decreases expression
|
mRNA |
22960397
|
| C031927 | 81930 |
KIF18A
MS-KIF18A |
kinesin family member 18A | hydroquinone results in decreased expression of KIF18A mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 4254 |
KITLG
FPH2 KL-1 Kitl MGF SCF SF SHEP7 |
KIT ligand | hydroquinone results in increased expression of KITLG mRNA |
increases expression
|
mRNA |
22960397
|
| C031927 | 3910 |
LAMA4
CMD1JJ LAMA3 LAMA4*-1 |
laminin, alpha 4 | hydroquinone results in increased expression of LAMA4 protein |
increases expression
|
protein |
18055817
|
| C031927 | 3910 |
LAMA4
CMD1JJ LAMA3 LAMA4*-1 |
laminin, alpha 4 | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 3910 |
LAMA4
CMD1JJ LAMA3 LAMA4*-1 |
laminin, alpha 4 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 3910 |
LAMA4
CMD1JJ LAMA3 LAMA4*-1 |
laminin, alpha 4 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | Dactinomycin inhibits the reaction [hydroquinone results in increased expression of LECT1 protein] |
decreases reaction
/ increases expression |
protein |
19525446
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | hydroquinone results in increased expression of and results in increased secretion of LECT1 protein |
increases expression
/ increases secretion |
protein |
19525446
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | hydroquinone results in increased expression of LECT1 mRNA |
increases expression
|
mRNA |
19525446
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | LECT1 protein results in increased susceptibility to hydroquinone |
increases response to substance
|
protein |
19525446
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | NQO1 protein inhibits the reaction [hydroquinone results in increased expression of LECT1 protein] |
decreases reaction
/ increases expression |
protein |
19525446
|
| C031927 | 11061 |
LECT1
BRICD3 CHM-I CHM1 MYETS1 |
leukocyte cell derived chemotaxin 1 | NQO1 protein inhibits the reaction [LECT1 protein results in increased susceptibility to hydroquinone] |
decreases reaction
/ increases response to substance |
protein |
19525446
|
| C031927 | 4000 |
LMNA
CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC LDP1 LFP LGMD1B LMN1 LMNC LMNL1 PRO1 |
lamin A/C | hydroquinone affects the expression of LMNA protein |
affects expression
|
protein |
17181942
|
| C031927 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK1 protein |
affects cotreatment
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | hydroquinone results in increased phosphorylation of and results in increased activity of MAPK1 protein |
increases activity
/ increases phosphorylation |
protein |
15129224
|
| C031927 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK3 protein |
affects cotreatment
/ increases activity / increases phosphorylation |
protein |
15129224
|
| C031927 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | hydroquinone results in increased phosphorylation of and results in increased activity of MAPK3 protein |
increases activity
/ increases phosphorylation |
protein |
15129224
|
| C031927 | 8932 |
MBD2
DMTase NY-CO-41 |
methyl-CpG binding domain protein 2 | hydroquinone results in decreased expression of MBD2 mRNA |
decreases expression
|
mRNA |
22245671
|
| C031927 | 4257 |
MGST1
GST12 MGST MGST-I |
microsomal glutathione S-transferase 1 (EC:2.5.1.18) | hydroquinone results in increased expression of MGST1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | [MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
affects cotreatment
/ decreases activity / decreases reaction |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | MMP14 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
decreases activity
/ decreases reaction |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | MMP14 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 4324 |
MMP15
MT2-MMP MTMMP2 SMCP-2 |
matrix metallopeptidase 15 (membrane-inserted) (EC:3.4.24.-) | hydroquinone affects the expression of MMP15 mRNA |
affects expression
|
mRNA |
15452088
|
| C031927 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | hydroquinone results in decreased activity of MMP2 protein |
decreases activity
|
protein |
16936130
18055817 |
| C031927 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | [MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
affects cotreatment
/ decreases activity / decreases reaction |
protein |
18055817
|
| C031927 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | MMP14 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
decreases activity
/ decreases reaction |
protein |
18055817
|
| C031927 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
decreases activity
/ decreases reaction |
protein |
18055817
|
| C031927 | 4314 |
MMP3
CHDS6 MMP-3 SL-1 STMY STMY1 STR1 |
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) | hydroquinone affects the expression of MMP3 mRNA |
affects expression
|
mRNA |
15452088
|
| C031927 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] |
decreases reaction
/ increases expression / increases secretion |
protein |
17669387
|
| C031927 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | hydroquinone promotes the reaction [TNF protein results in increased secretion of MMP9 protein] |
increases reaction
/ increases secretion |
protein |
17669387
|
| C031927 | 4352 |
MPL
C-MPL CD110 MPLV THCYT2 TPOR |
myeloproliferative leukemia virus oncogene | decitabine promotes the reaction [hydroquinone results in increased expression of MPL mRNA] |
increases expression
/ increases reaction |
mRNA |
22245671
|
| C031927 | 4352 |
MPL
C-MPL CD110 MPLV THCYT2 TPOR |
myeloproliferative leukemia virus oncogene | hydroquinone results in decreased methylation of MPL gene |
decreases methylation
|
gene |
22245671
|
| C031927 | 4352 |
MPL
C-MPL CD110 MPLV THCYT2 TPOR |
myeloproliferative leukemia virus oncogene | hydroquinone results in increased expression of MPL mRNA |
increases expression
|
mRNA |
22245671
|
| C031927 | 4353 |
MPO
|
myeloperoxidase (EC:1.11.2.2) | MPO protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein] |
affects reaction
/ increases cleavage |
protein |
15777082
|
| C031927 | 4353 |
MPO
|
myeloperoxidase (EC:1.11.2.2) | [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] |
affects cotreatment
/ decreases activity / increases reaction |
protein |
15935818
|
| C031927 | 4353 |
MPO
|
myeloperoxidase (EC:1.11.2.2) | MPO protein results in increased chemical synthesis of hydroquinone |
increases chemical synthesis
|
protein |
1666626
|
| C031927 | 4353 |
MPO
|
myeloperoxidase (EC:1.11.2.2) | [MPO protein results in increased hydroxylation of Phenol] which results in increased chemical synthesis of hydroquinone |
increases chemical synthesis
/ increases hydroxylation |
protein |
1666626
|
| C031927 | 4353 |
MPO
|
myeloperoxidase (EC:1.11.2.2) | MPO protein results in increased oxidation of hydroquinone |
increases oxidation
|
protein |
10994872
|
| C031927 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MYC protein] |
decreases reaction
/ increases expression |
protein |
12749906
|
| C031927 | 4778 |
NFE2
NF-E2 p45 |
nuclear factor, erythroid 2 | hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C031927 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of NFE2L2 promoter] |
decreases reaction
/ increases activity |
promoter |
21643505
|
| C031927 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | hydroquinone results in increased activity of NFE2L2 promoter |
increases activity
|
promoter |
21643505
|
| C031927 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | hydroquinone results in increased expression of and affects the localization of NFE2L2 protein |
affects localization
/ increases expression |
protein |
21059386
|
| C031927 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of GSS protein] |
affects reaction
/ increases expression |
mRNA |
21059386
|
| C031927 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of HMOX1 protein] |
affects reaction
/ increases expression |
mRNA |
21059386
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | hydroquinone results in increased expression of and results in increased activity of NQO1 protein |
increases activity
/ increases expression |
protein |
10393963
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | hydroquinone results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
8652659
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | hydroquinone results in increased expression of NQO1 protein |
increases expression
|
protein |
21059386
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | NQO1 protein inhibits the reaction [hydroquinone results in increased expression of LECT1 protein] |
decreases reaction
/ increases expression |
protein |
19525446
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | NQO1 protein inhibits the reaction [LECT1 protein results in increased susceptibility to hydroquinone] |
decreases reaction
/ increases response to substance |
protein |
19525446
|
| C031927 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | NQO1 protein results in decreased susceptibility to hydroquinone |
decreases response to substance
|
protein |
10368308
|
| C031927 | 5036 |
PA2G4
EBP1 HG4-1 p38-2G4 |
proliferation-associated 2G4, 38kDa | hydroquinone affects the expression of PA2G4 protein |
affects expression
|
protein |
17181942
|
| C031927 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | hydroquinone results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
19064679
|
| C031927 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | WRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
19064679
|
| C031927 | 25796 |
PGLS
6PGL |
6-phosphogluconolactonase (EC:3.1.1.31) | hydroquinone affects the expression of PGLS protein |
affects expression
|
protein |
17181942
|
| C031927 | 5429 |
POLH
RAD30 RAD30A XP-V XPV |
polymerase (DNA directed), eta (EC:2.7.7.7) | POLH mutant form results in increased susceptibility to hydroquinone |
increases response to substance
|
mutant form |
22981619
|
| C031927 | 5429 |
POLH
RAD30 RAD30A XP-V XPV |
polymerase (DNA directed), eta (EC:2.7.7.7) | [POLH mutant form results in increased susceptibility to hydroquinone] which results in increased expression of H2AFX protein |
increases expression
/ increases response to substance |
mutant form |
22981619
|
| C031927 | 8493 |
PPM1D
PP2C-DELTA WIP1 |
protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) | hydroquinone results in increased expression of PPM1D mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 5052 |
PRDX1
MSP23 NKEF-A NKEFA PAG PAGA PAGB PRX1 PRXI TDPX2 |
peroxiredoxin 1 (EC:1.11.1.15) | hydroquinone results in increased expression of PRDX1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 5591 |
PRKDC
DNA-PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 |
protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) | hydroquinone results in increased expression of PRKDC mRNA |
increases expression
|
mRNA |
20036648
|
| C031927 | 5591 |
PRKDC
DNA-PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 |
protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) | hydroquinone results in increased expression of PRKDC protein |
increases expression
|
protein |
20036648
|
| C031927 | 84722 |
PSRC1
DDA3 FP3214 |
proline/serine-rich coiled-coil 1 | hydroquinone results in decreased expression of PSRC1 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 9401 |
RECQL4
RECQ4 |
RecQ protein-like 4 (EC:3.6.4.12) | hydroquinone results in increased expression of RECQL4 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases expression |
protein |
16928326
|
| C031927 | 860 |
RUNX2
AML3 CBF-alpha-1 CBFA1 CCD CCD1 CLCD OSF-2 OSF2 PEA2aA PEBP2aA |
runt-related transcription factor 2 | hydroquinone results in increased expression of RUNX2 mRNA |
increases expression
|
mRNA |
22960397
|
| C031927 | 27244 |
SESN1
PA26 SEST1 |
sestrin 1 | hydroquinone results in increased expression of SESN1 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 83667 |
SESN2
HI95 SES2 SEST2 |
sestrin 2 | hydroquinone results in increased expression of SESN2 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | hydroquinone results in decreased activity of SOD1 protein |
decreases activity
|
protein |
15816534
|
| C031927 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | hydroquinone results in decreased expression of SOD1 mRNA |
decreases expression
|
mRNA |
15816534
|
| C031927 | 6648 |
SOD2
IPOB MNSOD MVCD6 |
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | hydroquinone results in decreased activity of SOD2 protein |
decreases activity
|
protein |
15816534
|
| C031927 | 6648 |
SOD2
IPOB MNSOD MVCD6 |
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | hydroquinone results in decreased expression of SOD2 mRNA |
decreases expression
|
mRNA |
15816534
|
| C031927 | 6688 |
SPI1
OF PU.1 SFPI1 SPI-1 SPI-A |
spleen focus forming virus (SFFV) proviral integration oncogene | hydroquinone results in increased phosphorylation of SPI1 protein |
increases phosphorylation
|
protein |
16642264
|
| C031927 | 8614 |
STC2
STC-2 STCRP |
stanniocalcin 2 | hydroquinone results in increased expression of STC2 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFRC protein] |
decreases reaction
/ increases expression |
protein |
12749906
|
| C031927 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA] |
decreases expression
/ increases reaction |
mRNA |
21414390
|
| C031927 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | hydroquinone results in decreased expression of TFRC protein |
decreases expression
|
protein |
21414390
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | [MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
affects cotreatment
/ decreases activity / decreases reaction |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
decreases activity
/ decreases reaction |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 7077 |
TIMP2
CSC-21K DDC8 |
TIMP metallopeptidase inhibitor 2 | TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
decreases reaction
/ increases expression |
protein |
18055817
|
| C031927 | 25976 |
TIPARP
ARTD14 PARP7 pART14 |
TCDD-inducible poly(ADP-ribose) polymerase (EC:2.4.2.30) | hydroquinone results in increased expression of TIPARP mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] |
decreases reaction
/ increases expression / increases secretion |
protein |
17669387
|
| C031927 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
10890505
|
| C031927 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroquinone promotes the reaction [TNF protein results in increased secretion of MMP9 protein] |
increases reaction
/ increases secretion |
protein |
17669387
|
| C031927 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroquinone results in decreased activity of TNF protein |
decreases activity
|
protein |
9571986
|
| C031927 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroquinone results in increased secretion of TNF protein |
increases secretion
|
protein |
17118622
|
| C031927 | 8795 |
TNFRSF10B
CD262 DR5 KILLER KILLER/DR5 TRAIL-R2 TRAILR2 TRICK2 TRICK2A TRICK2B TRICKB ZTNFR9 |
tumor necrosis factor receptor superfamily, member 10b | hydroquinone results in decreased expression of TNFRSF10B mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 8793 |
TNFRSF10D
CD264 DCR2 TRAIL-R4 TRAILR4 TRUNDD |
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | hydroquinone results in decreased expression of TNFRSF10D mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8718 |
TNFRSF25
APO-3 DDR3 DR3 LARD TNFRSF12 TR3 TRAMP WSL-1 WSL-LR |
tumor necrosis factor receptor superfamily, member 25 | hydroquinone results in decreased expression of TNFRSF25 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 3604 |
TNFRSF9
4-1BB CD137 CDw137 ILA |
tumor necrosis factor receptor superfamily, member 9 | hydroquinone results in increased expression of TNFRSF9 mRNA |
increases expression
|
mRNA |
22723965
|
| C031927 | 8742 |
TNFSF12
APO3L DR3LG TWEAK |
tumor necrosis factor (ligand) superfamily, member 12 | hydroquinone results in decreased expression of TNFSF12 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | hydroquinone affects the activity of TOP2A protein |
affects activity
|
protein |
15833037
|
| C031927 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | hydroquinone results in decreased activity of TOP2A protein |
decreases activity
|
protein |
9118903
11468185 15935818 20034485 |
| C031927 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] |
affects cotreatment
/ decreases activity / increases reaction |
protein |
15935818
|
| C031927 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | hydroquinone results in increased expression of TP53 protein |
increases expression
|
protein |
17875398
|
| C031927 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | WRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein] |
affects reaction
/ increases acetylation |
protein |
17875398
|
| C031927 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | WRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein] |
affects reaction
/ increases expression |
protein |
17875398
|
| C031927 | 94241 |
TP53INP1
SIP TP53DINP1 TP53INP1A TP53INP1B Teap p53DINP1 |
tumor protein p53 inducible nuclear protein 1 | hydroquinone results in increased expression of TP53INP1 mRNA |
increases expression
|
mRNA |
23416264
|
| C031927 | 8717 |
TRADD
Hs.89862 |
TNFRSF1A-associated via death domain | hydroquinone results in increased expression of TRADD mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 9618 |
TRAF4
CART1 MLN62 RNF83 |
TNF receptor-associated factor 4 | hydroquinone results in decreased expression of TRAF4 mRNA |
decreases expression
|
mRNA |
15452088
|
| C031927 | 286827 |
TRIM59
MRF1 RNF104 TRIM57 TSBF1 |
tripartite motif containing 59 | hydroquinone results in decreased expression of TRIM59 mRNA |
decreases expression
|
mRNA |
23416264
|
| C031927 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | hydroquinone results in increased activity of TRPA1 protein |
increases activity
|
protein |
21591660
|
| C031927 | 7295 |
TXN
TRDX TRX TRX1 |
thioredoxin | hydroquinone results in increased expression of TXN mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | hydroquinone results in increased expression of TXNRD1 mRNA |
increases expression
|
mRNA |
15452088
|
| C031927 | 7474 |
WNT5A
hWNT5A |
wingless-type MMTV integration site family, member 5A | hydroquinone results in increased expression of WNT5A mRNA |
increases expression
|
mRNA |
22960397
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AFX protein alternative form] |
increases expression
/ increases reaction |
gene |
21267443
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN gene mutant form results in increased susceptibility to hydroquinone |
increases response to substance
|
gene |
21267443
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein] |
affects reaction
/ increases acetylation |
protein |
17875398
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein affects the reaction [hydroquinone results in increased expression of H2AFX protein] |
affects reaction
/ increases expression |
protein |
17875398
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein] |
affects reaction
/ increases expression |
protein |
17875398
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein] |
decreases reaction
/ increases cleavage |
protein |
19064679
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
19064679
|
| C031927 | 7486 |
WRN
RECQ3 RECQL2 RECQL3 |
Werner syndrome, RecQ helicase-like (EC:3.6.4.12) | WRN protein results in decreased susceptibility to hydroquinone |
decreases response to substance
|
protein |
17875398
18978339 19064679 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (48)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #603903 | Sickle cell anemia |
P68871
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (51)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00020 | Colorectal cancer |
P68871
(marker)
|
| H00022 | Bladder cancer |
P68871
(marker)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
14 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001855 | C031927 | Bone Marrow Diseases |
marker/mechanism
|
2551665
|
|
| D002869 | C031927 | Chromosome Aberrations |
marker/mechanism
|
10706450
21267443 |
|
| D019457 | C031927 | Chromosome Breakage |
marker/mechanism
|
7517507
|
|
| D056486 | C031927 | Drug-Induced Liver Injury |
therapeutic
|
20054000
|
|
| D004487 | C031927 | Edema |
therapeutic
|
20054000
|
|
| D007674 | C031927 | Kidney Diseases |
marker/mechanism
|
9450487
|
|
| D007680 | C031927 | Kidney Neoplasms |
marker/mechanism
|
9450487
|
|
| D008548 | C031927 | Melanosis |
therapeutic
|
22151936
|
|
| D048629 | C031927 | Micronuclei, Chromosome-Defective |
marker/mechanism
|
2676505
3764927 14599448 19059273 |
|
| D009784 | C031927 | Occupational Diseases |
marker/mechanism
|
9930093
|
|
| D011041 | C031927 | Poisoning |
marker/mechanism
|
8291054
8818868 9930093 |
|
| D011123 | C031927 | Polyploidy |
marker/mechanism
|
7517507
|
|
| D012140 | C031927 | Respiratory Tract Diseases |
marker/mechanism
|
22414385
|
|
| D012772 | C031927 | Shock, Septic |
therapeutic
|
20054000
|