PCIDB

KNApSAcK Metabolite C00029420

Metabolite

KNApSAcK Entry

id C00029420
Name 1-Deoxynojirimycin / (+)-1-Deoxynojirimycin
CAS RN 19130-96-2
Standard InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
Standard InChI (Main Layer) InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 786

Link

ChEMBL

By standard InChI CHEMBL307429
By standard InChI Main Layer CHEMBL11510 CHEMBL65131 CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL179347 CHEMBL179409 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL1337303

KEGG

By LinkDB C16843

CTD

By CAS RN D017485

Human Protein / Gene in interaction

33 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL110458 CHEMBL179130 CHEMBL1337303 CHEMBL1741321 (3)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL11510 CHEMBL2114744 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL307429 CHEMBL110458 CHEMBL369297 CHEMBL647636 (1) CHEMBL647638 (1)
CHEMBL875446 (1) CHEMBL820814 (1)
CHEMBL818907 (1) CHEMBL823888 (1)
CHEMBL823889 (1) CHEMBL823892 (1)
CHEMBL993569 (1) CHEMBL1070063 (1)
CHEMBL1614515 (1) CHEMBL1614044 (1)
CHEMBL1678469 (1) CHEMBL1678657 (1)
CHEMBL1678658 (1) CHEMBL1678659 (1)
CHEMBL1678660 (1) CHEMBL1678661 (1)
CHEMBL1613818 (2) CHEMBL1820866 (2)
CHEMBL2184150 (1)
6 / 4
Q14697 Neutral alpha-glucosidase AB Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL640816 (1) CHEMBL641726 (1)
CHEMBL641729 (3) CHEMBL641731 (1)
CHEMBL645811 (2) CHEMBL645964 (2)
CHEMBL645965 (2) CHEMBL645966 (2)
CHEMBL645967 (1) CHEMBL645968 (1)
CHEMBL646083 (1) CHEMBL646084 (1)
CHEMBL646335 (2) CHEMBL646336 (1)
CHEMBL649333 (1) CHEMBL818494 (1)
CHEMBL818495 (1) CHEMBL822531 (1)
CHEMBL822533 (1) CHEMBL822534 (1)
CHEMBL822536 (1) CHEMBL822538 (1)
CHEMBL822539 (1) CHEMBL822540 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL647267 (1) CHEMBL647269 (1)
CHEMBL647151 (1) CHEMBL649344 (1)
CHEMBL993567 (1) CHEMBL993579 (1)
CHEMBL1040324 (1) CHEMBL1099885 (4)
CHEMBL1614175 (3) CHEMBL1614378 (1)
CHEMBL1614472 (1) CHEMBL1614076 (1)
CHEMBL1614440 (1) CHEMBL1614357 (3)
CHEMBL2344837 (1)
1 / 1
Q9H227 Cytosolic beta-glucosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL829476 (3) CHEMBL826964 (2)
CHEMBL830659 (10)
0 / 0
P35573 Glycogen debranching enzyme Enzyme CHEMBL307429 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL1099886 (4)
1 / 1
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL84844 CHEMBL1613776 (1)
3 / 1
P16278 Beta-galactosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL828604 (1) CHEMBL831935 (11)
4 / 6
P04066 Tissue alpha-L-fucosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL1337303 CHEMBL649569 (1) CHEMBL649570 (1)
CHEMBL649571 (2) CHEMBL649586 (5)
CHEMBL649591 (1) CHEMBL826963 (2)
CHEMBL829455 (2) CHEMBL831591 (1)
CHEMBL830658 (8)
1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL110458 CHEMBL179130 CHEMBL1337303 CHEMBL1741325 (3)
0 / 1
P23458 Tyrosine-protein kinase JAK1 Jakb CHEMBL307429 CHEMBL84844 CHEMBL1960067 (2) CHEMBL1960068 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1337303 CHEMBL1614458 (1)
0 / 0
P14410 Sucrase-isomaltase, intestinal Enzyme CHEMBL307429 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL997400 (1) CHEMBL1099880 (4)
1 / 1
P06280 Alpha-galactosidase A Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL648734 (1) CHEMBL831670 (4)
CHEMBL831209 (8) CHEMBL1168041 (1)
CHEMBL1614217 (1) CHEMBL1614369 (1)
1 / 1
Q13133 Oxysterols receptor LXR-alpha NR1H3 CHEMBL307429 CHEMBL933514 (1)
0 / 0
O00462 Beta-mannosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL823893 (1) CHEMBL823894 (1)
CHEMBL830660 (12)
1 / 2
Q9HCG7 Non-lysosomal glucosylceramidase Enzyme CHEMBL307429 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL1040323 (1) CHEMBL1070064 (1)
CHEMBL1099884 (4) CHEMBL2174537 (1)
1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL110458 CHEMBL179130 CHEMBL1337303 CHEMBL1741322 (3)
0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 CHEMBL307429 CHEMBL933515 (1)
0 / 0
P09848 Lactase-phlorizin hydrolase Enzyme CHEMBL307429 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL1099882 (4)
1 / 1
Q16739 Ceramide glucosyltransferase Transferase CHEMBL307429 CHEMBL110458 CHEMBL179409 CHEMBL175901 CHEMBL1099879 (4)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL110458 CHEMBL1337303 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL110458 CHEMBL179130 CHEMBL1337303 CHEMBL1613777 (1) CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL110458 CHEMBL179130 CHEMBL1337303 CHEMBL1741324 (3)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL110458 CHEMBL1614211 (1)
0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL179409 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL710106 (1) CHEMBL827835 (1)
CHEMBL829855 (11) CHEMBL856853 (1)
CHEMBL1099881 (4)
0 / 0
O43280 Trehalase Enzyme CHEMBL307429 CHEMBL827814 (1)
0 / 0
O00754 Lysosomal alpha-mannosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL877464 (1) CHEMBL829856 (11)
1 / 2
Q6P4F1 Alpha-(1,3)-fucosyltransferase 10 Enzyme CHEMBL307429 CHEMBL681260 (1)
0 / 0
Q9Y2E5 Epididymis-specific alpha-mannosidase Enzyme CHEMBL307429 CHEMBL84844 CHEMBL110458 CHEMBL369297 CHEMBL179085 CHEMBL176206 CHEMBL179130 CHEMBL179347 CHEMBL179409 CHEMBL176021 CHEMBL369046 CHEMBL176209 CHEMBL368121 CHEMBL175901 CHEMBL832878 (2) CHEMBL830540 (12)
0 / 0
O00255 Menin Unclassified protein CHEMBL110458 CHEMBL1337303 CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL110458 CHEMBL1337303 CHEMBL1614531 (2)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#230000 Fucosidosis P04066
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#232400 Glycogen storage disease iii P35573
#230500 Gm1-gangliosidosis, type i P16278
#230600 Gm1-gangliosidosis, type ii P16278
#230650 Gm1-gangliosidosis, type iii P16278
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#223000 Lactase deficiency, congenital P09848
#248500 Mannosidosis, alpha b, lysosomal; mansa O00754
#248510 Mannosidosis, beta a, lysosomal; mansb O00462
#253010 Mucopolysaccharidosis type ivb P16278
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#168600 Parkinson disease, late-onset; pd P04062
#614409 Spastic paraplegia 46, autosomal recessive; spg46 Q9HCG7
#222900 Sucrase-isomaltase deficiency, congenital; csid P14410
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (27)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00140 beta-Mannosidosis O00462 (related)
H00422 Glycoproteinoses O00462 (related)
O00754 (related)
P04066 (related)
P16278 (related)
H00139 alpha-Mannosidosis O00754 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
P16278 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00141 Fucosidosis P04066 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00116 Congenital lactase deficiency P09848 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
P35573 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00115 Congenital sucrase-isomaltase deficiency P14410 (related)
H00123 Mucopolysaccharidosis type IV (MPS4) P16278 (related)
H00276 Galactosialidosis P16278 (related)
H00281 GM1 gangliosidosis P16278 (related)
H00421 Mucopolysaccharidosis (MPS) P16278 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)