Species

KNApSAcK Entry

Organism name Juniperus brevifolia
Genus Juniperus
Family Cupressaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Juniperus brevifolia
Linked NCBI taxonomy ID 746017
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023287 External link 512 Z-Communic acid
/ Elliotinoic acid
/ (Z)-Communic acid
/ cis-Communic acid
CHEMBL498097
CHEMBL1488779
CHEMBL1731589
13 / 14 / 8 No. 143
C00031283 External link 512 Sandaracopimaric acid
/ (-)-Sandaracopimaric acid
CHEMBL513197
CHEMBL1397211
CHEMBL1410398
CHEMBL1735595
C082072
14 / 13 / 7 No. 208 No. 48
C00031398 External link 512 Sugiol
/ (+)-Sugiol
CHEMBL195296
No. 355
C00034167 External link 512 Pomiferin A
/ (+)-Pomiferin A
/ 18-Hydroxy-dehydroabietane
CHEMBL12799
No. 359 No. 40
C00033803 External link 512 Eicosanyl-trans-p-coumarate
No. 447
C00016987 External link 512 Nootkatone
/ Nootkanone
/ (+)-Nootkatone
/ 4betaH,5alpha-Eremophila-1(10),11-dien-2-one
CHEMBL446299
4 / 2 / 1 No. 543 No. 38

Human Protein / Gene in interactions

40 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 C00016987 C00031283 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00023287 C00031283 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00023287 C00031283 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00023287 C00031283 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00023287 C00031283 7 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 C00031283 0 / 1
P06746 DNA polymerase beta Enzyme C00003672 C00023287 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00031283 0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00031283 1 / 1
P39748 Flap endonuclease 1 Enzyme C00023287 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00031283 2 / 0
O75496 Geminin Unclassified protein C00031283 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00031283 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00016987 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00031283 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00016987 1 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00023287 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00016987 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00023287 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00023287 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00023287 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00031283 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00023287 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00031283 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00023287 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00023287 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (21)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)