Species

KNApSAcK Entry

Organism name Millettia thonningii
Genus Millettia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Millettia thonningii
Linked NCBI taxonomy ID 53626
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019156 External link 512 5-O-Methyl-4'-O-(3-methylbut-2-enyl)alpinumisoflavone
No. 18 No. 15
C00003738 External link 512 beta-Amyrin
/ beta-Amirin
/ beta-Amyrine
/ beta-Amyrenol
C036380
0 / 4 No. 23 No. 51
C00009503 External link 512 Robustone
CHEMBL252722
3 / 11 / 40 No. 24 No. 15
C00009492 External link 512 Alpinumisoflavone
CHEMBL238628
C000154
3 / 1 / 1 1 / 0 No. 24 No. 15
C00009506 External link 512 3'-Hydroxyalpinumisoflavone 4'-methyl ether
CHEMBL549827
No. 24 No. 15
C00019041 External link 512 Indicanine C
/ 5-Methoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
No. 24 No. 15
C00009504 External link 512 Alpinumisoflavone dimethyl ether
No. 24 No. 15
C00019513 External link 512 Thonninginisoflavone
/ 5,4'-Dimethoxy-5''-(1-methylethenyl)-4'',5''-dihydrofurano[2'',3'':7,6]isoflavone
No. 236 No. 15
C00010045 External link 512 Thonningine B
No. 3353
C00019157 External link 512 Thonningin C
/ 4-Hydroxy-5,3',4'-trimethoxy-5''-(1-methylethenyl)-4'',5''-dihydrofurano[2'',3'':7,6]-3-phenylcoumarin
No. 3353
C00010044 External link 512 Thonningine A
No. 3353

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00009492 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00009503 7 / 37
Q92731 Estrogen receptor beta NR3A2 C00009492 0 / 1
P03372 Estrogen receptor NR3A1 C00009492 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00009503 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00009503 4 / 3

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00009492

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (40)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005157 Facial Pain C00003738
D006930 Hyperalgesia C00003738
D007249 Inflammation C00003738
D010146 Pain C00003738