Species

KNApSAcK Entry

Organism name Cassia renigera
Genus Cassia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cassia renigera
Linked NCBI taxonomy ID 1231245
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003838 External link 512 Pectolinarigenin
CHEMBL78010
C079207
31 / 27 / 19 No. 3 No. 15
C00008434 External link 512 Isosakuranetin 7-O-rhamnoside
No. 12 No. 14
C00000568 External link 512 Chrysophanol
CHEMBL41092
C027113
20 / 17 / 20 1 / 0 No. 41 No. 62
C00008361 External link 512 5-Hydroxy-6,7,3',4',5'-pentamethoxyflavanone 5-O-rhamnoside
No. 3026
C00001227 External link 512 Malvalic acid
C008318
No. 4256 No. 70
C00001239 External link 512 Sterculic acid
C003345
No. 4256 No. 70

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000568 C00003838 4 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000568 C00003838 1 / 2
O00255 Menin Unclassified protein C00000568 C00003838 2 / 5
P10636 Microtubule-associated protein tau Unclassified protein C00000568 C00003838 4 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000568 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000568 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00000568 0 / 0
O75496 Geminin Unclassified protein C00003838 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003838 0 / 0
Q99700 Ataxin-2 Unclassified protein C00003838 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003838 7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000568 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000568 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000568 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003838 1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000568 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003838 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000568 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000568 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000568 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000568 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000568 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000568 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000568 3 / 2
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000568 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000568 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00003838 0 / 0
P06746 DNA polymerase beta Enzyme C00003838 0 / 0
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00003838 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003838 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003838 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00003838 0 / 0
P68366 Tubulin alpha-4A chain Structural C00003838 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00003838 1 / 0
P04350 Tubulin beta-4A chain Structural C00003838 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00003838 0 / 0
P07437 Tubulin beta chain Structural C00003838 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00003838 1 / 1
P68371 Tubulin beta-4B chain Structural C00003838 0 / 0
Q13509 Tubulin beta-3 chain Structural C00003838 2 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003838 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00003838 0 / 0
Q13885 Tubulin beta-2A chain Structural C00003838 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00003838 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00003838 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00003838 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00003838 1 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000568

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (26)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)