PCIDB

Ruta montana

Species

KNApSAcK Entry

Organism name Ruta montana
Genus Ruta
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ruta montana
Linked NCBI taxonomy ID 266085
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00002476 External link 512 Herniarin
/ 7-Methoxycoumarin
CHEMBL49732
C007929
23 / 10 / 12 No. 864 No. 25
C00026380 External link 512 2-(8-Oxononyl)quinolin-4(1H)-one
/ 2-(Nonan-8-one)-(1H)-4-quinolone
No. 884
C00026377 External link 512 1-Methyl-2-(9-oxodecyl)quinolin-4-one
No. 884
C00026389 External link 512 N-Methyl-4-methoxycarbostyril
/ 4-Methoxy-1-methyl-2-quinolone
/ 1-Methyl-4-methoxy-2-quinolone
CHEMBL402069
2 / 0 / 3 No. 3424

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 C00002476 2 / 2
Q9UNA4 DNA polymerase iota Enzyme C00000601 C00026389 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002476 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002476 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002476 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
P23280 Carbonic anhydrase 6 Lyase C00002476 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002476 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002476 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002476 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00002476 1 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P15121 Aldose reductase Enzyme C00002476 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002476 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002476 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P56817 Beta-secretase 1 A1A C00002476 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002476 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002476 3 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00002476 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 0 / 1
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002476 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00002476 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002476 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002476 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002476 0 / 0
O14980 Exportin-1 Unclassified protein C00002476 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002476 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00026389 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#218030 Apparent mineralocorticoid excess; ame P80365
#114500 Colorectal cancer; crc P84022
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#600852 Retinitis pigmentosa 17; rp17 P22748
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (28)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601