Centaurea americana
Species
KNApSAcK Entry
| Organism name | Centaurea americana |
|---|---|
| Genus | Centaurea |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Plectocephalus americanus |
|---|---|
| Linked NCBI taxonomy ID | 41506 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000606
|
(-)-Matairesinol
|
CHEMBL425148
|
C068935
|
1 / 0 / 0 | No. 223 | No. 21 |
|
|
|
C00000609
|
(-)-Arctigenin
|
CHEMBL369142
CHEMBL435734 CHEMBL1966556 |
C071942
|
13 / 7 / 6 | No. 223 | No. 21 |
|
|
|
C00000646
|
(-)-Arctiin
|
CHEMBL388452
CHEMBL1526371 |
C077992
|
4 / 15 / 11 | 0 / 2 | No. 653 | No. 22 |
|
|
C00032004
|
Matairesinoside
/ (-)-Matairesinoside |
CHEMBL459834
CHEMBL520065 |
No. 653 | No. 22 |
|
|||
|
C00000687
|
Lappaol A
|
No. 1420 |
|
|||||
|
C00031592
|
Americanin
/ Americanin A |
CHEMBL482240
|
C055022
|
No. 1955 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000609 | 1 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000609 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000646 | 4 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000609 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000646 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000609 | 0 / 1 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000606 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000609 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00000646 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000609 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000609 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000646 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000609 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000609 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000609 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000609 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000609 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000609 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (22)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
KEGG DISEASE (17)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|