Species

KNApSAcK Entry

Organism name Centaurea cyanus
Genus Centaurea
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Centaurea cyanus
Linked NCBI taxonomy ID 41522
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (14)

Species Activity
Centaurea cyanus L. Antibacterial
Centaurea cyanus L. Antipyretic
Centaurea cyanus L. Antiseptic
Centaurea cyanus L. Astringent
Centaurea cyanus L. Cholagogue
Centaurea cyanus L. Collyrium
Centaurea cyanus L. Diuretic
Centaurea cyanus L. Emmenagogue
Centaurea cyanus L. Expectorant
Centaurea cyanus L. Fungicide
Centaurea cyanus L. Hepatotonic
Centaurea cyanus L. Pectoral
Centaurea cyanus L. Stimulant
Centaurea cyanus L. Tonic

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006817 External link 512 Succinylcyanin
No. 1 No. 15
C00004196 External link 512 Apigenin 7-glucuronide-4'-(6''-malonylglucoside)
No. 1 No. 15
C00006765 External link 512 Pelargonidin 3-(6''-succinylglucoside)-5-glucoside
No. 1 No. 15
C00006796 External link 512 Cyanidin 3-(6''-malonylglucoside)
/ Cyanidin-3-O-(6-O-malonyl-beta-D-glucopyranoside)
CHEMBL1173160
No. 2 No. 15
C00006129 External link 512 Isoswertisin
/ 7-O-Methylvitexin
/ Isoflavocommelitin
/ 8-beta-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
No. 22 No. 15
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00027005 External link 512 Moschamine
/ (E)-Moschamine
CHEMBL564482
3 / 4 / 5 No. 1533
C00027006 External link 512 Centcyamine
No. 1533
C00027007 External link 512 cis-Moschamine
/ (Z)-Moschamine
CHEMBL564482
3 / 4 / 5 No. 1533
C00027008 External link 512 cis-Centcyamine
No. 1533

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00027005 C00027007 0 / 3
P14679 Tyrosinase Oxidoreductase C00027005 C00027007 4 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00027005 C00027007 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
Q99700 Ataxin-2 Unclassified protein C00000609 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000609 1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000609 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000609 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000609 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#257220 Niemann-pick disease, type c1; npc1 O15118
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (11)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)