PCIDB

Cynara cardunculus

Species

KNApSAcK Entry

Organism name Cynara cardunculus
Genus Cynara
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cynara cardunculus
Linked NCBI taxonomy ID 4265
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (23)

Species Activity
Cynara cardunculus L. subsp. Cardunculus Antiaggregant
Cynara cardunculus L. subsp. Cardunculus Antiartherosclerotic
Cynara cardunculus L. subsp. Cardunculus Antiemetic
Cynara cardunculus L. subsp. Cardunculus Antiinflammatory
Cynara cardunculus L. subsp. Cardunculus Antioxidant
Cynara cardunculus L. subsp. Cardunculus Antispasmodic
Cynara cardunculus L. subsp. Cardunculus Antitumor
Cynara cardunculus L. subsp. Cardunculus Aperitif
Cynara cardunculus L. subsp. Cardunculus Aphrodisiac
Cynara cardunculus L. subsp. Cardunculus Bitter
Cynara cardunculus L. subsp. Cardunculus Carminative
Cynara cardunculus L. subsp. Cardunculus Cholagogue
Cynara cardunculus L. subsp. Cardunculus Cholekinetic
Cynara cardunculus L. subsp. Cardunculus Choleretic
Cynara cardunculus L. subsp. Cardunculus Deodorant
Cynara cardunculus L. subsp. Cardunculus Depurative
Cynara cardunculus L. subsp. Cardunculus Digestive
Cynara cardunculus L. subsp. Cardunculus Diuretic
Cynara cardunculus L. subsp. Cardunculus Hepatoprotective
Cynara cardunculus L. subsp. Cardunculus Hepatotonic
Cynara cardunculus L. subsp. Cardunculus Hypocholesterolemic
Cynara cardunculus L. subsp. Cardunculus Hypoglycemic
Cynara cardunculus L. subsp. Cardunculus Hypolipidemic

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00038907 External link 512 Cynarasaponin J
No. 9 No. 51
C00038906 External link 512 Cynarasaponin H
CHEMBL1288834
No. 9 No. 51
C00003243 External link 512 Cynaropicrin
CHEMBL374146
C075687
1 / 0 / 0 No. 206 No. 38
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00002733 External link 512 1,3-Dicaffeoylquinic acid
CHEMBL431948
CHEMBL487258
CHEMBL478574
CHEMBL1213299
CHEMBL2105478
CHEMBL2356300
6 / 5 / 7 No. 518 No. 6
C00020855 External link 512 Cynaratriol
No. 608

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000609 1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
Q99700 Ataxin-2 Unclassified protein C00000609 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002733 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003243 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002733 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000609 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002733 1 / 1
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000609 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000609 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002733 0 / 1
P24298 Alanine aminotransferase 1 Enzyme C00002733 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002733 3 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#209950 Atypical mycobacteriosis, familial P42224
#614162 Candidiasis, familial, 7; candf7 P42224
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#245590 Growth hormone insensitivity with immunodeficiency P51692
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#257220 Niemann-pick disease, type c1; npc1 O15118
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (13)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)